Zika virus IgG in infants with microcephaly, Guinea-Bissau, 2016

Maiken Worsøe Rosenstierne; Frederik Schaltz-Buchholzer; Fernanda Bruzadelli; Asson Có; Placido Cardoso; Charlotte Sværke Jørgensen; Johan Michiels; Leo Heyndrickx; Kevin K. Ariën; Thea Kølsen Fischer; Anders Fomsgaard

doi:10.3201/eid2405.180153

Zika virus IgG in infants with microcephaly, Guinea-Bissau, 2016

Maiken Worsøe Rosenstierne^*
, Frederik Schaltz-Buchholzer
, Fernanda Bruzadelli
, Asson Có
, Placido Cardoso
, Charlotte Sværke Jørgensen
, Johan Michiels
, Leo Heyndrickx
, Kevin K. Ariën
, Thea Kølsen Fischer
, Anders Fomsgaard

^*Corresponding author for this work

KI, OUH, Research unit of Infectious Diseases (Odense)

Statens Serum Institut
Instituto Nacional de Saúde Pública
Institute of Tropical Medicine Antwerp
University of Antwerp
Bandim Health Project
Field Epidemiology Training Program

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

We analyzed blood samples from infants born with microcephaly and their mothers in Guinea-Bissau in 2016 for pathogens associated with birth defects. No Zika virus RNA was detected, but Zika virus IgG was highly prevalent. We recommend implementing pathogen screening of infants with congenital defects in Guinea-Bissau.

Original language	English
Journal	Emerging Infectious Diseases
Volume	24
Issue number	5
Pages (from-to)	948-950
Number of pages	3
ISSN	1080-6059
DOIs	https://doi.org/10.3201/eid2405.180153
Publication status	Published - 1. May 2018

Funding

K.K.A. is supported by ZikaPLAN through the European Union’s Horizon 2020 Research and Innovation Programme (grant no. 734584).

Keywords

Antibodies, Viral
Female
Fluorescent Antibody Technique
Guinea-Bissau/epidemiology
Humans
Immunoglobulin G
Infant, Newborn
Microcephaly/epidemiology
Pregnancy
Pregnancy Complications, Infectious/epidemiology
Zika Virus Infection/complications
Zika Virus/isolation & purification

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10.3201/eid2405.180153Licence: CC BY

18-0153Final published version, 339 KBLicence: CC BY

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title = "Zika virus IgG in infants with microcephaly, Guinea-Bissau, 2016",

abstract = "We analyzed blood samples from infants born with microcephaly and their mothers in Guinea-Bissau in 2016 for pathogens associated with birth defects. No Zika virus RNA was detected, but Zika virus IgG was highly prevalent. We recommend implementing pathogen screening of infants with congenital defects in Guinea-Bissau.",

keywords = "Antibodies, Viral, Female, Fluorescent Antibody Technique, Guinea-Bissau/epidemiology, Humans, Immunoglobulin G, Infant, Newborn, Microcephaly/epidemiology, Pregnancy, Pregnancy Complications, Infectious/epidemiology, Zika Virus Infection/complications, Zika Virus/isolation \& purification",

author = "Rosenstierne, \{Maiken Wors{\o}e\} and Frederik Schaltz-Buchholzer and Fernanda Bruzadelli and Asson C{\'o} and Placido Cardoso and J{\o}rgensen, \{Charlotte Sv{\ae}rke\} and Johan Michiels and Leo Heyndrickx and Ari{\"e}n, \{Kevin K.\} and Fischer, \{Thea K{\o}lsen\} and Anders Fomsgaard",

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month = may,

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doi = "10.3201/eid2405.180153",

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T1 - Zika virus IgG in infants with microcephaly, Guinea-Bissau, 2016

AU - Rosenstierne, Maiken Worsøe

AU - Schaltz-Buchholzer, Frederik

AU - Bruzadelli, Fernanda

AU - Có, Asson

AU - Cardoso, Placido

AU - Jørgensen, Charlotte Sværke

AU - Michiels, Johan

AU - Heyndrickx, Leo

AU - Ariën, Kevin K.

AU - Fischer, Thea Kølsen

AU - Fomsgaard, Anders

PY - 2018/5/1

Y1 - 2018/5/1

N2 - We analyzed blood samples from infants born with microcephaly and their mothers in Guinea-Bissau in 2016 for pathogens associated with birth defects. No Zika virus RNA was detected, but Zika virus IgG was highly prevalent. We recommend implementing pathogen screening of infants with congenital defects in Guinea-Bissau.

AB - We analyzed blood samples from infants born with microcephaly and their mothers in Guinea-Bissau in 2016 for pathogens associated with birth defects. No Zika virus RNA was detected, but Zika virus IgG was highly prevalent. We recommend implementing pathogen screening of infants with congenital defects in Guinea-Bissau.

KW - Antibodies, Viral

KW - Female

KW - Fluorescent Antibody Technique

KW - Guinea-Bissau/epidemiology

KW - Humans

KW - Immunoglobulin G

KW - Infant, Newborn

KW - Microcephaly/epidemiology

KW - Pregnancy

KW - Pregnancy Complications, Infectious/epidemiology

KW - Zika Virus Infection/complications

KW - Zika Virus/isolation & purification

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DO - 10.3201/eid2405.180153

M3 - Journal article

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AN - SCOPUS:85045653214

SN - 1080-6059

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SP - 948

EP - 950

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 5

ER -

Zika virus IgG in infants with microcephaly, Guinea-Bissau, 2016

Abstract

Funding

Keywords

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