Worldwide Utilization of Topical Remedies in Treatment of Psoriasis: A Systematic Review

Mathias Tiedemann Svendsen, Janithika Jeyabalan, Klaus Ejner Andersen, Flemming Andersen, Helle Johannessen

Research output: Contribution to journalReviewResearchpeer-review

Abstract

Objective: To review published literature describing the global use of topical antipsoriatics. Materials and methods: Search for English-language articles in Embase, Pubmed, PsycINFO and Cochrane Library. Results: Fifty-four selected publications were found, describing psoriasis patients’ use of topical antipsoriatics, using six different methods to collect data. The eight most frequently used topical treatments from the regions North/South America, North/Central/South Europe, Asia, Middle East and Australia were: corticosteroids used by 16–79%, complementary and alternative medicines used by 10–62%, phototherapies used by 0.4–75%, calcipotriol used by 4.2–73%, corticosteroid/calcipotriol combinations used by 3.3–71%, tar used by 0.8–66%, anthralin used by 15% and emollients used as monotherapy by 1–23%. Rates of patient-reported adherence to topical remedies ranged from 51% to 90% and rates of patient-reported satisfaction with topical as it pertains to symptom control ranged from 12% to 52%. Conclusion: The identified use patterns are varying and reflect a lack of data from large parts of the world and noncomparable studies using heterogeneous study designs. However, this study emphasizes the importance of medical professionals involvement of the patient with respect to choosing prescribed topical treatment and the possibility of patients’ use of alternative treatments. More drug utilization studies, both survey and register based, from different parts of the world are needed to provide more conclusive evidence about patients’ use of topical antipsoriatics.

Original languageEnglish
JournalJournal of Dermatological Treatment
Volume28
Issue number5
Pages (from-to)374-383
ISSN0954-6634
DOIs
Publication statusPublished - Aug 2017

Fingerprint

Psoriasis
Adrenal Cortex Hormones
Emollients
Drug Utilization
North America
PubMed
Libraries
Publications
Language
calcipotriene

Keywords

  • Psoriasis
  • corticosteroids
  • topical treatment
  • utilization
  • Adrenal Cortex Hormones/therapeutic use
  • Humans
  • Psoriasis/drug therapy
  • Dermatologic Agents/therapeutic use
  • Anthralin/therapeutic use
  • Patient Compliance
  • Drug Therapy, Combination
  • Administration, Topical
  • Calcitriol/analogs & derivatives

Cite this

@article{0f54f50ddc544bfc84b2776ced2f9553,
title = "Worldwide Utilization of Topical Remedies in Treatment of Psoriasis: A Systematic Review",
abstract = "Objective: To review published literature describing the global use of topical antipsoriatics. Materials and methods: Search for English-language articles in Embase, Pubmed, PsycINFO and Cochrane Library. Results: Fifty-four selected publications were found, describing psoriasis patients’ use of topical antipsoriatics, using six different methods to collect data. The eight most frequently used topical treatments from the regions North/South America, North/Central/South Europe, Asia, Middle East and Australia were: corticosteroids used by 16–79{\%}, complementary and alternative medicines used by 10–62{\%}, phototherapies used by 0.4–75{\%}, calcipotriol used by 4.2–73{\%}, corticosteroid/calcipotriol combinations used by 3.3–71{\%}, tar used by 0.8–66{\%}, anthralin used by 15{\%} and emollients used as monotherapy by 1–23{\%}. Rates of patient-reported adherence to topical remedies ranged from 51{\%} to 90{\%} and rates of patient-reported satisfaction with topical as it pertains to symptom control ranged from 12{\%} to 52{\%}. Conclusion: The identified use patterns are varying and reflect a lack of data from large parts of the world and noncomparable studies using heterogeneous study designs. However, this study emphasizes the importance of medical professionals involvement of the patient with respect to choosing prescribed topical treatment and the possibility of patients’ use of alternative treatments. More drug utilization studies, both survey and register based, from different parts of the world are needed to provide more conclusive evidence about patients’ use of topical antipsoriatics.",
keywords = "Psoriasis, corticosteroids, topical treatment, utilization, Adrenal Cortex Hormones/therapeutic use, Humans, Psoriasis/drug therapy, Dermatologic Agents/therapeutic use, Anthralin/therapeutic use, Patient Compliance, Drug Therapy, Combination, Administration, Topical, Calcitriol/analogs & derivatives",
author = "Svendsen, {Mathias Tiedemann} and Janithika Jeyabalan and Andersen, {Klaus Ejner} and Flemming Andersen and Helle Johannessen",
year = "2017",
month = "8",
doi = "10.1080/09546634.2016.1254331",
language = "English",
volume = "28",
pages = "374--383",
journal = "Journal of Dermatological Treatment",
issn = "0954-6634",
publisher = "Taylor & Francis",
number = "5",

}

Worldwide Utilization of Topical Remedies in Treatment of Psoriasis : A Systematic Review. / Svendsen, Mathias Tiedemann; Jeyabalan, Janithika; Andersen, Klaus Ejner; Andersen, Flemming; Johannessen, Helle.

In: Journal of Dermatological Treatment, Vol. 28, No. 5, 08.2017, p. 374-383 .

Research output: Contribution to journalReviewResearchpeer-review

TY - JOUR

T1 - Worldwide Utilization of Topical Remedies in Treatment of Psoriasis

T2 - A Systematic Review

AU - Svendsen, Mathias Tiedemann

AU - Jeyabalan, Janithika

AU - Andersen, Klaus Ejner

AU - Andersen, Flemming

AU - Johannessen, Helle

PY - 2017/8

Y1 - 2017/8

N2 - Objective: To review published literature describing the global use of topical antipsoriatics. Materials and methods: Search for English-language articles in Embase, Pubmed, PsycINFO and Cochrane Library. Results: Fifty-four selected publications were found, describing psoriasis patients’ use of topical antipsoriatics, using six different methods to collect data. The eight most frequently used topical treatments from the regions North/South America, North/Central/South Europe, Asia, Middle East and Australia were: corticosteroids used by 16–79%, complementary and alternative medicines used by 10–62%, phototherapies used by 0.4–75%, calcipotriol used by 4.2–73%, corticosteroid/calcipotriol combinations used by 3.3–71%, tar used by 0.8–66%, anthralin used by 15% and emollients used as monotherapy by 1–23%. Rates of patient-reported adherence to topical remedies ranged from 51% to 90% and rates of patient-reported satisfaction with topical as it pertains to symptom control ranged from 12% to 52%. Conclusion: The identified use patterns are varying and reflect a lack of data from large parts of the world and noncomparable studies using heterogeneous study designs. However, this study emphasizes the importance of medical professionals involvement of the patient with respect to choosing prescribed topical treatment and the possibility of patients’ use of alternative treatments. More drug utilization studies, both survey and register based, from different parts of the world are needed to provide more conclusive evidence about patients’ use of topical antipsoriatics.

AB - Objective: To review published literature describing the global use of topical antipsoriatics. Materials and methods: Search for English-language articles in Embase, Pubmed, PsycINFO and Cochrane Library. Results: Fifty-four selected publications were found, describing psoriasis patients’ use of topical antipsoriatics, using six different methods to collect data. The eight most frequently used topical treatments from the regions North/South America, North/Central/South Europe, Asia, Middle East and Australia were: corticosteroids used by 16–79%, complementary and alternative medicines used by 10–62%, phototherapies used by 0.4–75%, calcipotriol used by 4.2–73%, corticosteroid/calcipotriol combinations used by 3.3–71%, tar used by 0.8–66%, anthralin used by 15% and emollients used as monotherapy by 1–23%. Rates of patient-reported adherence to topical remedies ranged from 51% to 90% and rates of patient-reported satisfaction with topical as it pertains to symptom control ranged from 12% to 52%. Conclusion: The identified use patterns are varying and reflect a lack of data from large parts of the world and noncomparable studies using heterogeneous study designs. However, this study emphasizes the importance of medical professionals involvement of the patient with respect to choosing prescribed topical treatment and the possibility of patients’ use of alternative treatments. More drug utilization studies, both survey and register based, from different parts of the world are needed to provide more conclusive evidence about patients’ use of topical antipsoriatics.

KW - Psoriasis

KW - corticosteroids

KW - topical treatment

KW - utilization

KW - Adrenal Cortex Hormones/therapeutic use

KW - Humans

KW - Psoriasis/drug therapy

KW - Dermatologic Agents/therapeutic use

KW - Anthralin/therapeutic use

KW - Patient Compliance

KW - Drug Therapy, Combination

KW - Administration, Topical

KW - Calcitriol/analogs & derivatives

U2 - 10.1080/09546634.2016.1254331

DO - 10.1080/09546634.2016.1254331

M3 - Review

C2 - 27786594

VL - 28

SP - 374

EP - 383

JO - Journal of Dermatological Treatment

JF - Journal of Dermatological Treatment

SN - 0954-6634

IS - 5

ER -