Whole-genome sequencing for identification of the source in hospital-acquired Legionnaires' disease

A M Rosendahl Madsen; A Holm; T G Jensen; E Knudsen; H Lundgaard; M N Skov; S A Uldum; M Kemp

doi:10.1016/j.jhin.2017.04.020

Whole-genome sequencing for identification of the source in hospital-acquired Legionnaires' disease

A M Rosendahl Madsen, A Holm, T G Jensen, E Knudsen, H Lundgaard, M N Skov, S A Uldum, M Kemp

KI, OUH, Research unit of Clinical Microbiology (Odense)

Statens Serum Institut

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Acquisition of Legionnaires' disease is a serious complication of hospitalization. Rapid determination of whether or not the infection is caused by strains of Legionella pneumophila in the hospital environment is crucial to avoid further cases. This study investigated the use of whole-genome sequencing to identify the source of infection in hospital-acquired Legionnaires' disease. Phylogenetic analyses showed close relatedness between one patient isolate and a strain found in hospital water, confirming suspicion of nosocomial infection. It was found that whole-genome sequencing can be a useful tool in the investigation of hospital-acquired Legionnaires' disease.

Original language	English
Journal	Journal of Hospital Infection
Volume	96
Issue number	4
Pages (from-to)	392-395
ISSN	0195-6701
DOIs	https://doi.org/10.1016/j.jhin.2017.04.020
Publication status	Published - 2017

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Journal Article

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10.1016/j.jhin.2017.04.020

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title = "Whole-genome sequencing for identification of the source in hospital-acquired Legionnaires' disease",

abstract = "Acquisition of Legionnaires' disease is a serious complication of hospitalization. Rapid determination of whether or not the infection is caused by strains of Legionella pneumophila in the hospital environment is crucial to avoid further cases. This study investigated the use of whole-genome sequencing to identify the source of infection in hospital-acquired Legionnaires' disease. Phylogenetic analyses showed close relatedness between one patient isolate and a strain found in hospital water, confirming suspicion of nosocomial infection. It was found that whole-genome sequencing can be a useful tool in the investigation of hospital-acquired Legionnaires' disease.",

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doi = "10.1016/j.jhin.2017.04.020",

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T1 - Whole-genome sequencing for identification of the source in hospital-acquired Legionnaires' disease

AU - Rosendahl Madsen, A M

AU - Holm, A

AU - Jensen, T G

AU - Knudsen, E

AU - Lundgaard, H

AU - Skov, M N

AU - Uldum, S A

AU - Kemp, M

PY - 2017

Y1 - 2017

N2 - Acquisition of Legionnaires' disease is a serious complication of hospitalization. Rapid determination of whether or not the infection is caused by strains of Legionella pneumophila in the hospital environment is crucial to avoid further cases. This study investigated the use of whole-genome sequencing to identify the source of infection in hospital-acquired Legionnaires' disease. Phylogenetic analyses showed close relatedness between one patient isolate and a strain found in hospital water, confirming suspicion of nosocomial infection. It was found that whole-genome sequencing can be a useful tool in the investigation of hospital-acquired Legionnaires' disease.

AB - Acquisition of Legionnaires' disease is a serious complication of hospitalization. Rapid determination of whether or not the infection is caused by strains of Legionella pneumophila in the hospital environment is crucial to avoid further cases. This study investigated the use of whole-genome sequencing to identify the source of infection in hospital-acquired Legionnaires' disease. Phylogenetic analyses showed close relatedness between one patient isolate and a strain found in hospital water, confirming suspicion of nosocomial infection. It was found that whole-genome sequencing can be a useful tool in the investigation of hospital-acquired Legionnaires' disease.

KW - Journal Article

U2 - 10.1016/j.jhin.2017.04.020

DO - 10.1016/j.jhin.2017.04.020

M3 - Journal article

C2 - 28622979

SN - 0195-6701

VL - 96

SP - 392

EP - 395

JO - Journal of Hospital Infection

JF - Journal of Hospital Infection

IS - 4

ER -

Whole-genome sequencing for identification of the source in hospital-acquired Legionnaires' disease

Abstract

Keywords

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