Whole blood mercury and the risk of cardiovascular disease among the Greenlandic population

Trine Jul Larsen, Marit Eika Jørgensen, Christina Viskum Lytken Larsen, Inger Katrine Dahl-Petersen, Pernille Falberg Rønn, Peter Bjerregaard, Stine Byberg*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Background: Studies have found mercury to be associated with cardiovascular disease (CVD), however, primarily in populations with low exposure. The highest levels, and variations in the levels, of whole blood mercury (WBM) worldwide have been found in Greenland. We prospectively assessed the association between WBM and the risk of developing CVD in the Greenlandic population. Methods: We assessed the effects of WBM levels on incident CVD among 3083 Greenlandic Inuit, participating in a population-based cohort study conducted from 2005 to 2010. WBM was measured at baseline. Participants were followed in the National Patient Registries for Denmark and Greenland and in the causes of death register for CVD events from inclusion in the study until CVD event, emigration, death or end of follow-up (30/9–2013). Using Cox regression analyses, we calculated the incidence rates and the hazard ratio of CVD events according to WBM levels. Potential interactions with sex were also investigated. Results: The highest levels of WBM were found in men, who had a significantly higher median level (19 μg/L (IQR:1–44)), compared with women (15 μg/L (IQR: 1–32), (p < 0.001)). The crude hazard ratio (HR) for incident CVD was 1.00 (95% CI 1.00–1.00) for 5 µg/l increase in WBM. After adjusting for several potential confounders, there was still no association between WBM and incident CVD (HR 0.99; 95%CI:0.99–1.00). We found no interactions with sex. Conclusions: In a population with high levels of WBM, we found no association between WBM and the risk of developing CVD in Greenland.

Original languageEnglish
JournalEnvironmental Research
Volume164
Pages (from-to)310-315
ISSN0013-9351
DOIs
Publication statusPublished - 1. Jul 2018

Fingerprint

cardiovascular disease
Mercury
Blood
blood
Population
Greenland
Hazards
hazard
mercury
cause of death
Emigration and Immigration
emigration
Denmark
Registries
Cause of Death
Cohort Studies
Regression Analysis

Keywords

  • Cardiovascular disease
  • Greenland
  • Inuit
  • Whole blood mercury

Cite this

Larsen, Trine Jul ; Jørgensen, Marit Eika ; Larsen, Christina Viskum Lytken ; Dahl-Petersen, Inger Katrine ; Rønn, Pernille Falberg ; Bjerregaard, Peter ; Byberg, Stine. / Whole blood mercury and the risk of cardiovascular disease among the Greenlandic population. In: Environmental Research. 2018 ; Vol. 164. pp. 310-315.
@article{a5dc84d15d494363908875b42e5b74eb,
title = "Whole blood mercury and the risk of cardiovascular disease among the Greenlandic population",
abstract = "Background: Studies have found mercury to be associated with cardiovascular disease (CVD), however, primarily in populations with low exposure. The highest levels, and variations in the levels, of whole blood mercury (WBM) worldwide have been found in Greenland. We prospectively assessed the association between WBM and the risk of developing CVD in the Greenlandic population. Methods: We assessed the effects of WBM levels on incident CVD among 3083 Greenlandic Inuit, participating in a population-based cohort study conducted from 2005 to 2010. WBM was measured at baseline. Participants were followed in the National Patient Registries for Denmark and Greenland and in the causes of death register for CVD events from inclusion in the study until CVD event, emigration, death or end of follow-up (30/9–2013). Using Cox regression analyses, we calculated the incidence rates and the hazard ratio of CVD events according to WBM levels. Potential interactions with sex were also investigated. Results: The highest levels of WBM were found in men, who had a significantly higher median level (19 μg/L (IQR:1–44)), compared with women (15 μg/L (IQR: 1–32), (p < 0.001)). The crude hazard ratio (HR) for incident CVD was 1.00 (95{\%} CI 1.00–1.00) for 5 µg/l increase in WBM. After adjusting for several potential confounders, there was still no association between WBM and incident CVD (HR 0.99; 95{\%}CI:0.99–1.00). We found no interactions with sex. Conclusions: In a population with high levels of WBM, we found no association between WBM and the risk of developing CVD in Greenland.",
keywords = "Cardiovascular disease, Greenland, Inuit, Whole blood mercury",
author = "Larsen, {Trine Jul} and J{\o}rgensen, {Marit Eika} and Larsen, {Christina Viskum Lytken} and Dahl-Petersen, {Inger Katrine} and R{\o}nn, {Pernille Falberg} and Peter Bjerregaard and Stine Byberg",
year = "2018",
month = "7",
day = "1",
doi = "10.1016/j.envres.2018.03.003",
language = "English",
volume = "164",
pages = "310--315",
journal = "Environmental Research",
issn = "0013-9351",
publisher = "Heinemann",

}

Whole blood mercury and the risk of cardiovascular disease among the Greenlandic population. / Larsen, Trine Jul; Jørgensen, Marit Eika; Larsen, Christina Viskum Lytken; Dahl-Petersen, Inger Katrine; Rønn, Pernille Falberg; Bjerregaard, Peter; Byberg, Stine.

In: Environmental Research, Vol. 164, 01.07.2018, p. 310-315.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Whole blood mercury and the risk of cardiovascular disease among the Greenlandic population

AU - Larsen, Trine Jul

AU - Jørgensen, Marit Eika

AU - Larsen, Christina Viskum Lytken

AU - Dahl-Petersen, Inger Katrine

AU - Rønn, Pernille Falberg

AU - Bjerregaard, Peter

AU - Byberg, Stine

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Background: Studies have found mercury to be associated with cardiovascular disease (CVD), however, primarily in populations with low exposure. The highest levels, and variations in the levels, of whole blood mercury (WBM) worldwide have been found in Greenland. We prospectively assessed the association between WBM and the risk of developing CVD in the Greenlandic population. Methods: We assessed the effects of WBM levels on incident CVD among 3083 Greenlandic Inuit, participating in a population-based cohort study conducted from 2005 to 2010. WBM was measured at baseline. Participants were followed in the National Patient Registries for Denmark and Greenland and in the causes of death register for CVD events from inclusion in the study until CVD event, emigration, death or end of follow-up (30/9–2013). Using Cox regression analyses, we calculated the incidence rates and the hazard ratio of CVD events according to WBM levels. Potential interactions with sex were also investigated. Results: The highest levels of WBM were found in men, who had a significantly higher median level (19 μg/L (IQR:1–44)), compared with women (15 μg/L (IQR: 1–32), (p < 0.001)). The crude hazard ratio (HR) for incident CVD was 1.00 (95% CI 1.00–1.00) for 5 µg/l increase in WBM. After adjusting for several potential confounders, there was still no association between WBM and incident CVD (HR 0.99; 95%CI:0.99–1.00). We found no interactions with sex. Conclusions: In a population with high levels of WBM, we found no association between WBM and the risk of developing CVD in Greenland.

AB - Background: Studies have found mercury to be associated with cardiovascular disease (CVD), however, primarily in populations with low exposure. The highest levels, and variations in the levels, of whole blood mercury (WBM) worldwide have been found in Greenland. We prospectively assessed the association between WBM and the risk of developing CVD in the Greenlandic population. Methods: We assessed the effects of WBM levels on incident CVD among 3083 Greenlandic Inuit, participating in a population-based cohort study conducted from 2005 to 2010. WBM was measured at baseline. Participants were followed in the National Patient Registries for Denmark and Greenland and in the causes of death register for CVD events from inclusion in the study until CVD event, emigration, death or end of follow-up (30/9–2013). Using Cox regression analyses, we calculated the incidence rates and the hazard ratio of CVD events according to WBM levels. Potential interactions with sex were also investigated. Results: The highest levels of WBM were found in men, who had a significantly higher median level (19 μg/L (IQR:1–44)), compared with women (15 μg/L (IQR: 1–32), (p < 0.001)). The crude hazard ratio (HR) for incident CVD was 1.00 (95% CI 1.00–1.00) for 5 µg/l increase in WBM. After adjusting for several potential confounders, there was still no association between WBM and incident CVD (HR 0.99; 95%CI:0.99–1.00). We found no interactions with sex. Conclusions: In a population with high levels of WBM, we found no association between WBM and the risk of developing CVD in Greenland.

KW - Cardiovascular disease

KW - Greenland

KW - Inuit

KW - Whole blood mercury

U2 - 10.1016/j.envres.2018.03.003

DO - 10.1016/j.envres.2018.03.003

M3 - Journal article

VL - 164

SP - 310

EP - 315

JO - Environmental Research

JF - Environmental Research

SN - 0013-9351

ER -