What to expect after open heart valve surgery? Changes in health-related quality of life

Britt Borregaard, Susanne S. Pedersen, Selina Kikkenborg Berg, Jordi Dahl, Ola Ekholm, Kirstine Lærum Sibilitz, Ann Dorthe Olsen Zwisler, Sandra B. Lauck, Derek Kyte, Melanie Calvert, Lars Riber, Jacob Eifer Møller

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

PURPOSE: To (i) describe changes in health-related quality of life (HRQoL) pre-operatively, at discharge, and 4 weeks after discharge following open heart surgery, (ii) compare the performance of the EuroQol Questionnaire (EQ-5D 5L) and the Kansas City Cardiomyopathy Questionnaire (KCCQ) against an anchor-based approach, and to (iii) investigate the association between HRQoL and 180-day readmission.

METHODS: A prospective, consecutive cohort (single-center study) of 291 patients completed the EQ-5D 5L and KCCQ pre-operatively, at discharge and 4 weeks post-discharge. Changes in HRQoL over time were evaluated, and the performance of the instruments was investigated. The association between HRQoL and readmission were investigated with Cox Proportional Hazard models.

RESULTS: Scores of the EQ-5D Index and VAS decreased significantly from the pre-operative assessment to discharge and improved from discharge to 4 weeks after. The KCCQ scores significantly improved from baseline to 4 weeks after. Minimal clinically important improvements from before surgery to 4 weeks after were seen among 24% (EQ-5D Index), 45% (EQ-5D VAS), and 57% (KCCQ). More than one-third experienced worse HRQoL 1 month after discharge. Area under the curve (AUC) (performance of the instruments) demonstrated the following: EQ-5D Index AUC 0.622 (95% CI 0.540-0.704), VAS AUC 0.674 (95% CI 0.598-0.750), and KCCQ AUC 0.722 (95% CI 0.65-0.792). None of the HRQoL measurements were associated with 180-day readmission.

CONCLUSIONS: This study revealed that HRQoL measured with the EQ-5D is significantly worse at discharge compared to before surgery, but scores increases within the first month measured with the EQ-5D and the KCCQ. The EQ-5D and KCCQ have a moderate correlation with an anchor-based approach but were not associated with readmission.

Original languageEnglish
JournalQuality of Life Research
ISSN0962-9343
DOIs
Publication statusE-pub ahead of print - 24. Dec 2019

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Heart Valves
Quality of Life
Area Under Curve
Surveys and Questionnaires
Proportional Hazards Models

Cite this

@article{77e4293b12b741d1ba9e4e26fb8c3e87,
title = "What to expect after open heart valve surgery? Changes in health-related quality of life",
abstract = "PURPOSE: To (i) describe changes in health-related quality of life (HRQoL) pre-operatively, at discharge, and 4 weeks after discharge following open heart surgery, (ii) compare the performance of the EuroQol Questionnaire (EQ-5D 5L) and the Kansas City Cardiomyopathy Questionnaire (KCCQ) against an anchor-based approach, and to (iii) investigate the association between HRQoL and 180-day readmission.METHODS: A prospective, consecutive cohort (single-center study) of 291 patients completed the EQ-5D 5L and KCCQ pre-operatively, at discharge and 4 weeks post-discharge. Changes in HRQoL over time were evaluated, and the performance of the instruments was investigated. The association between HRQoL and readmission were investigated with Cox Proportional Hazard models.RESULTS: Scores of the EQ-5D Index and VAS decreased significantly from the pre-operative assessment to discharge and improved from discharge to 4 weeks after. The KCCQ scores significantly improved from baseline to 4 weeks after. Minimal clinically important improvements from before surgery to 4 weeks after were seen among 24{\%} (EQ-5D Index), 45{\%} (EQ-5D VAS), and 57{\%} (KCCQ). More than one-third experienced worse HRQoL 1 month after discharge. Area under the curve (AUC) (performance of the instruments) demonstrated the following: EQ-5D Index AUC 0.622 (95{\%} CI 0.540-0.704), VAS AUC 0.674 (95{\%} CI 0.598-0.750), and KCCQ AUC 0.722 (95{\%} CI 0.65-0.792). None of the HRQoL measurements were associated with 180-day readmission.CONCLUSIONS: This study revealed that HRQoL measured with the EQ-5D is significantly worse at discharge compared to before surgery, but scores increases within the first month measured with the EQ-5D and the KCCQ. The EQ-5D and KCCQ have a moderate correlation with an anchor-based approach but were not associated with readmission.",
author = "Britt Borregaard and Pedersen, {Susanne S.} and {Kikkenborg Berg}, Selina and Jordi Dahl and Ola Ekholm and Sibilitz, {Kirstine L{\ae}rum} and Zwisler, {Ann Dorthe Olsen} and Lauck, {Sandra B.} and Derek Kyte and Melanie Calvert and Lars Riber and M{\o}ller, {Jacob Eifer}",
year = "2019",
month = "12",
day = "24",
doi = "10.1007/s11136-019-02400-9",
language = "English",
journal = "Quality of Life Research",
issn = "0962-9343",
publisher = "Springer",

}

What to expect after open heart valve surgery? Changes in health-related quality of life. / Borregaard, Britt; Pedersen, Susanne S.; Kikkenborg Berg, Selina; Dahl, Jordi; Ekholm, Ola; Sibilitz, Kirstine Lærum; Zwisler, Ann Dorthe Olsen; Lauck, Sandra B.; Kyte, Derek; Calvert, Melanie; Riber, Lars; Møller, Jacob Eifer.

In: Quality of Life Research, 24.12.2019.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - What to expect after open heart valve surgery? Changes in health-related quality of life

AU - Borregaard, Britt

AU - Pedersen, Susanne S.

AU - Kikkenborg Berg, Selina

AU - Dahl, Jordi

AU - Ekholm, Ola

AU - Sibilitz, Kirstine Lærum

AU - Zwisler, Ann Dorthe Olsen

AU - Lauck, Sandra B.

AU - Kyte, Derek

AU - Calvert, Melanie

AU - Riber, Lars

AU - Møller, Jacob Eifer

PY - 2019/12/24

Y1 - 2019/12/24

N2 - PURPOSE: To (i) describe changes in health-related quality of life (HRQoL) pre-operatively, at discharge, and 4 weeks after discharge following open heart surgery, (ii) compare the performance of the EuroQol Questionnaire (EQ-5D 5L) and the Kansas City Cardiomyopathy Questionnaire (KCCQ) against an anchor-based approach, and to (iii) investigate the association between HRQoL and 180-day readmission.METHODS: A prospective, consecutive cohort (single-center study) of 291 patients completed the EQ-5D 5L and KCCQ pre-operatively, at discharge and 4 weeks post-discharge. Changes in HRQoL over time were evaluated, and the performance of the instruments was investigated. The association between HRQoL and readmission were investigated with Cox Proportional Hazard models.RESULTS: Scores of the EQ-5D Index and VAS decreased significantly from the pre-operative assessment to discharge and improved from discharge to 4 weeks after. The KCCQ scores significantly improved from baseline to 4 weeks after. Minimal clinically important improvements from before surgery to 4 weeks after were seen among 24% (EQ-5D Index), 45% (EQ-5D VAS), and 57% (KCCQ). More than one-third experienced worse HRQoL 1 month after discharge. Area under the curve (AUC) (performance of the instruments) demonstrated the following: EQ-5D Index AUC 0.622 (95% CI 0.540-0.704), VAS AUC 0.674 (95% CI 0.598-0.750), and KCCQ AUC 0.722 (95% CI 0.65-0.792). None of the HRQoL measurements were associated with 180-day readmission.CONCLUSIONS: This study revealed that HRQoL measured with the EQ-5D is significantly worse at discharge compared to before surgery, but scores increases within the first month measured with the EQ-5D and the KCCQ. The EQ-5D and KCCQ have a moderate correlation with an anchor-based approach but were not associated with readmission.

AB - PURPOSE: To (i) describe changes in health-related quality of life (HRQoL) pre-operatively, at discharge, and 4 weeks after discharge following open heart surgery, (ii) compare the performance of the EuroQol Questionnaire (EQ-5D 5L) and the Kansas City Cardiomyopathy Questionnaire (KCCQ) against an anchor-based approach, and to (iii) investigate the association between HRQoL and 180-day readmission.METHODS: A prospective, consecutive cohort (single-center study) of 291 patients completed the EQ-5D 5L and KCCQ pre-operatively, at discharge and 4 weeks post-discharge. Changes in HRQoL over time were evaluated, and the performance of the instruments was investigated. The association between HRQoL and readmission were investigated with Cox Proportional Hazard models.RESULTS: Scores of the EQ-5D Index and VAS decreased significantly from the pre-operative assessment to discharge and improved from discharge to 4 weeks after. The KCCQ scores significantly improved from baseline to 4 weeks after. Minimal clinically important improvements from before surgery to 4 weeks after were seen among 24% (EQ-5D Index), 45% (EQ-5D VAS), and 57% (KCCQ). More than one-third experienced worse HRQoL 1 month after discharge. Area under the curve (AUC) (performance of the instruments) demonstrated the following: EQ-5D Index AUC 0.622 (95% CI 0.540-0.704), VAS AUC 0.674 (95% CI 0.598-0.750), and KCCQ AUC 0.722 (95% CI 0.65-0.792). None of the HRQoL measurements were associated with 180-day readmission.CONCLUSIONS: This study revealed that HRQoL measured with the EQ-5D is significantly worse at discharge compared to before surgery, but scores increases within the first month measured with the EQ-5D and the KCCQ. The EQ-5D and KCCQ have a moderate correlation with an anchor-based approach but were not associated with readmission.

U2 - 10.1007/s11136-019-02400-9

DO - 10.1007/s11136-019-02400-9

M3 - Journal article

C2 - 31875308

JO - Quality of Life Research

JF - Quality of Life Research

SN - 0962-9343

ER -