Wellbeing And Resilience: Mechanisms of transmission of health and risk in parents with complex mental health problems and their off-spring - the WARM study

Susanne Harder; Kirstine Davidsen; Angus MacBeth; Theis Lange; Helen Minnis; Marianne Skovsager Andersen; Erik Simonsen; Jenna-Marie Lundy; Maja Nyström-Hansen; Christopher Høier Trier; Katrine Røhder; Andrew Gumley

doi:10.1186/s12888-015-0692-6

Wellbeing And Resilience: Mechanisms of transmission of health and risk in parents with complex mental health problems and their off-spring - the WARM study

Susanne Harder, Kirstine Davidsen, Angus MacBeth, Theis Lange, Helen Minnis, Marianne Skovsager Andersen, Erik Simonsen, Jenna-Marie Lundy, Maja Nyström-Hansen, Christopher Høier Trier, Katrine Røhder, Andrew Gumley

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

UNLABELLED: The WARM study is a longitudinal cohort study following infants of mothers with schizophrenia, bipolar disorder, depression and control from pregnancy to infant 1 year of age.

BACKGROUND: Children of parents diagnosed with complex mental health problems including schizophrenia, bipolar disorder and depression, are at increased risk of developing mental health problems compared to the general population. Little is known regarding the early developmental trajectories of infants who are at ultra-high risk and in particular the balance of risk and protective factors expressed in the quality of early caregiver-interaction.

METHODS/DESIGN: We are establishing a cohort of pregnant women with a lifetime diagnosis of schizophrenia, bipolar disorder, major depressive disorder and a non-psychiatric control group. Factors in the parents, the infant and the social environment will be evaluated at 1, 4, 16 and 52 weeks in terms of evolution of very early indicators of developmental risk and resilience focusing on three possible environmental transmission mechanisms: stress, maternal caregiver representation, and caregiver-infant interaction.

DISCUSSION: The study will provide data on very early risk developmental status and associated psychosocial risk factors, which will be important for developing targeted preventive interventions for infants of parents with severe mental disorder.

TRIAL REGISTRATION: NCT02306551, date of registration November 12, 2014.

Original language	English
Article number	310
Journal	BMC Psychiatry
Volume	15
Issue number	1
Number of pages	13
ISSN	1471-244X
DOIs	https://doi.org/10.1186/s12888-015-0692-6
Publication status	Published - 9. Dec 2015

Keywords

Attachment
Bipolar disorder
Caregiving
Cohort study
Depression
High-risk infants
Risk development
Schizophrenia
Stress-sensitivity

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10.1186/s12888-015-0692-6Licence: CC BY

WARM ProtocolAccepted manuscript, 725 KB
Wellbeing and resilienceFinal published version, 816 KBLicence: CC BY

Cite this

Harder, S., Davidsen, K., MacBeth, A., Lange, T., Minnis, H., Andersen, M. S., Simonsen, E., Lundy, J.-M., Nyström-Hansen, M., Trier, C. H., Røhder, K., & Gumley, A. (2015). Wellbeing And Resilience: Mechanisms of transmission of health and risk in parents with complex mental health problems and their off-spring - the WARM study. BMC Psychiatry, 15(1), Article 310. https://doi.org/10.1186/s12888-015-0692-6

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title = "Wellbeing And Resilience: Mechanisms of transmission of health and risk in parents with complex mental health problems and their off-spring - the WARM study",

abstract = "UNLABELLED: The WARM study is a longitudinal cohort study following infants of mothers with schizophrenia, bipolar disorder, depression and control from pregnancy to infant 1 year of age.BACKGROUND: Children of parents diagnosed with complex mental health problems including schizophrenia, bipolar disorder and depression, are at increased risk of developing mental health problems compared to the general population. Little is known regarding the early developmental trajectories of infants who are at ultra-high risk and in particular the balance of risk and protective factors expressed in the quality of early caregiver-interaction.METHODS/DESIGN: We are establishing a cohort of pregnant women with a lifetime diagnosis of schizophrenia, bipolar disorder, major depressive disorder and a non-psychiatric control group. Factors in the parents, the infant and the social environment will be evaluated at 1, 4, 16 and 52 weeks in terms of evolution of very early indicators of developmental risk and resilience focusing on three possible environmental transmission mechanisms: stress, maternal caregiver representation, and caregiver-infant interaction.DISCUSSION: The study will provide data on very early risk developmental status and associated psychosocial risk factors, which will be important for developing targeted preventive interventions for infants of parents with severe mental disorder.TRIAL REGISTRATION: NCT02306551, date of registration November 12, 2014.",

keywords = "Attachment, Bipolar disorder, Caregiving, Cohort study, Depression, High-risk infants, Risk development, Schizophrenia, Stress-sensitivity",

author = "Susanne Harder and Kirstine Davidsen and Angus MacBeth and Theis Lange and Helen Minnis and Andersen, {Marianne Skovsager} and Erik Simonsen and Jenna-Marie Lundy and Maja Nystr{\"o}m-Hansen and Trier, {Christopher H{\o}ier} and Katrine R{\o}hder and Andrew Gumley",

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doi = "10.1186/s12888-015-0692-6",

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Harder, S, Davidsen, K, MacBeth, A, Lange, T, Minnis, H, Andersen, MS, Simonsen, E, Lundy, J-M, Nyström-Hansen, M, Trier, CH, Røhder, K & Gumley, A 2015, 'Wellbeing And Resilience: Mechanisms of transmission of health and risk in parents with complex mental health problems and their off-spring - the WARM study', BMC Psychiatry, vol. 15, no. 1, 310. https://doi.org/10.1186/s12888-015-0692-6

TY - JOUR

T1 - Wellbeing And Resilience

T2 - Mechanisms of transmission of health and risk in parents with complex mental health problems and their off-spring - the WARM study

AU - Harder, Susanne

AU - Davidsen, Kirstine

AU - MacBeth, Angus

AU - Lange, Theis

AU - Minnis, Helen

AU - Andersen, Marianne Skovsager

AU - Simonsen, Erik

AU - Lundy, Jenna-Marie

AU - Nyström-Hansen, Maja

AU - Trier, Christopher Høier

AU - Røhder, Katrine

AU - Gumley, Andrew

PY - 2015/12/9

Y1 - 2015/12/9

N2 - UNLABELLED: The WARM study is a longitudinal cohort study following infants of mothers with schizophrenia, bipolar disorder, depression and control from pregnancy to infant 1 year of age.BACKGROUND: Children of parents diagnosed with complex mental health problems including schizophrenia, bipolar disorder and depression, are at increased risk of developing mental health problems compared to the general population. Little is known regarding the early developmental trajectories of infants who are at ultra-high risk and in particular the balance of risk and protective factors expressed in the quality of early caregiver-interaction.METHODS/DESIGN: We are establishing a cohort of pregnant women with a lifetime diagnosis of schizophrenia, bipolar disorder, major depressive disorder and a non-psychiatric control group. Factors in the parents, the infant and the social environment will be evaluated at 1, 4, 16 and 52 weeks in terms of evolution of very early indicators of developmental risk and resilience focusing on three possible environmental transmission mechanisms: stress, maternal caregiver representation, and caregiver-infant interaction.DISCUSSION: The study will provide data on very early risk developmental status and associated psychosocial risk factors, which will be important for developing targeted preventive interventions for infants of parents with severe mental disorder.TRIAL REGISTRATION: NCT02306551, date of registration November 12, 2014.

AB - UNLABELLED: The WARM study is a longitudinal cohort study following infants of mothers with schizophrenia, bipolar disorder, depression and control from pregnancy to infant 1 year of age.BACKGROUND: Children of parents diagnosed with complex mental health problems including schizophrenia, bipolar disorder and depression, are at increased risk of developing mental health problems compared to the general population. Little is known regarding the early developmental trajectories of infants who are at ultra-high risk and in particular the balance of risk and protective factors expressed in the quality of early caregiver-interaction.METHODS/DESIGN: We are establishing a cohort of pregnant women with a lifetime diagnosis of schizophrenia, bipolar disorder, major depressive disorder and a non-psychiatric control group. Factors in the parents, the infant and the social environment will be evaluated at 1, 4, 16 and 52 weeks in terms of evolution of very early indicators of developmental risk and resilience focusing on three possible environmental transmission mechanisms: stress, maternal caregiver representation, and caregiver-infant interaction.DISCUSSION: The study will provide data on very early risk developmental status and associated psychosocial risk factors, which will be important for developing targeted preventive interventions for infants of parents with severe mental disorder.TRIAL REGISTRATION: NCT02306551, date of registration November 12, 2014.

KW - Attachment

KW - Bipolar disorder

KW - Caregiving

KW - Cohort study

KW - Depression

KW - High-risk infants

KW - Risk development

KW - Schizophrenia

KW - Stress-sensitivity

U2 - 10.1186/s12888-015-0692-6

DO - 10.1186/s12888-015-0692-6

M3 - Journal article

C2 - 26654720

SN - 1471-244X

VL - 15

JO - BMC Psychiatry

JF - BMC Psychiatry

IS - 1

M1 - 310

ER -

Wellbeing And Resilience: Mechanisms of transmission of health and risk in parents with complex mental health problems and their off-spring - the WARM study

Abstract

Keywords

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