Watson-Crick hydrogen bonding of unlocked nucleic acids

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

We herein describe the synthesis of two new unlocked nucleic acid building blocks containing hypoxanthine and 2,6-diaminopurine as nucleobase moieties and their incorporation into oligonucleotides. The modified oligonucleotides were used to examine the thermodynamic properties of UNA against unmodified oligonucleotides and the resulting thermodynamic data support that the hydrogen bonding face of UNA is Watson-Crick like.

Original languageEnglish
JournalBioorganic & Medicinal Chemistry Letters
Volume25
Issue number22
Pages (from-to)5064-6
Number of pages3
ISSN0960-894X
DOIs
Publication statusPublished - 15. Nov 2015

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Hydrogen Bonding
Oligonucleotides
Nucleic Acids
Hydrogen bonds
Hypoxanthine
Thermodynamic properties
Thermodynamics

Cite this

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title = "Watson-Crick hydrogen bonding of unlocked nucleic acids",
abstract = "We herein describe the synthesis of two new unlocked nucleic acid building blocks containing hypoxanthine and 2,6-diaminopurine as nucleobase moieties and their incorporation into oligonucleotides. The modified oligonucleotides were used to examine the thermodynamic properties of UNA against unmodified oligonucleotides and the resulting thermodynamic data support that the hydrogen bonding face of UNA is Watson-Crick like.",
author = "Niels Langkj{\ae}r and Jesper Wengel and Anna Pasternak",
note = "Copyright {\circledC} 2015 Elsevier Ltd. All rights reserved.",
year = "2015",
month = "11",
day = "15",
doi = "10.1016/j.bmcl.2015.10.024",
language = "English",
volume = "25",
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journal = "Bioorganic & Medicinal Chemistry Letters",
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publisher = "Pergamon Press",
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}

Watson-Crick hydrogen bonding of unlocked nucleic acids. / Langkjær, Niels; Wengel, Jesper; Pasternak, Anna.

In: Bioorganic & Medicinal Chemistry Letters, Vol. 25, No. 22, 15.11.2015, p. 5064-6.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Watson-Crick hydrogen bonding of unlocked nucleic acids

AU - Langkjær, Niels

AU - Wengel, Jesper

AU - Pasternak, Anna

N1 - Copyright © 2015 Elsevier Ltd. All rights reserved.

PY - 2015/11/15

Y1 - 2015/11/15

N2 - We herein describe the synthesis of two new unlocked nucleic acid building blocks containing hypoxanthine and 2,6-diaminopurine as nucleobase moieties and their incorporation into oligonucleotides. The modified oligonucleotides were used to examine the thermodynamic properties of UNA against unmodified oligonucleotides and the resulting thermodynamic data support that the hydrogen bonding face of UNA is Watson-Crick like.

AB - We herein describe the synthesis of two new unlocked nucleic acid building blocks containing hypoxanthine and 2,6-diaminopurine as nucleobase moieties and their incorporation into oligonucleotides. The modified oligonucleotides were used to examine the thermodynamic properties of UNA against unmodified oligonucleotides and the resulting thermodynamic data support that the hydrogen bonding face of UNA is Watson-Crick like.

U2 - 10.1016/j.bmcl.2015.10.024

DO - 10.1016/j.bmcl.2015.10.024

M3 - Journal article

C2 - 26497284

VL - 25

SP - 5064

EP - 5066

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

SN - 0960-894X

IS - 22

ER -