Von Willebrand Factor and Prekallikrein in Plasma Are Associated with Thrombus Volume in Abdominal Aortic Aneurysms

Qasam M. Ghulam, Kim K. Bredahl, Jørgen Brodersen Gram, Lars Lönn, J. P. Gøtze, Henrik Sillesen, Jonas P. Eiberg

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Objectives: Disruption of the endothelial lining may be one of the events linking intraluminal thrombus and abdominal aortic aneurysm growth. In the present study, we examined whether von Willebrand factor activity in plasma, contact proteins of blood coagulation, and inflammatory biomarkers may be associated with intraluminal thrombus volume in search of a biochemical marker of endothelial damage and thrombus size. Design: Prospective study, correlating potential endothelial biomarkers and intraluminal thrombus volume acquired by computed tomography angiography. Materials and Methods: Plasma was consecutively obtained from 38 patients with asymptomatic infrarenal abdominal aortic aneurysm. von Willebrand factor activity, thrombin generation time, factor XII, and prekallikrein concentration were measured in plasma on automated and in-house platforms. In total, 8 patients were excluded due to ongoing anticoagulant therapy, renal impairment, or nonappearance, thus leaving 30 patients for further analysis. All patients had computed tomography angiography, and intraluminal volume was quantified off-line by OsiriX 6.5. Results: Median intraluminal thrombus volume was 42.7 mL. Spearman correlation analysis revealed a positive correlation between thrombus volume, von Willebrand factor activity (I = 0.56, P =.0013), and prekallikrein concentration in plasma (I = 0.54, P =.002). Conclusion: von Willebrand factor activity and concentration of prekallikrein may both be of importance regarding the evolution of thrombus in abdominal aortic aneurysm and possible biomarkers for aneurysm growth. © The Author(s) 2016.
Original languageEnglish
JournalVascular and Endovascular Surgery
Volume50
Issue number6
Pages (from-to)391-397
ISSN1538-5744
DOIs
Publication statusPublished - Aug 2016

Keywords

  • abdominal aortic aneurysm
  • intraluminal thrombus
  • prekallikrein
  • thrombus volume
  • von Willebrand factor
  • Multidetector Computed Tomography
  • Predictive Value of Tests
  • Prognosis
  • Prospective Studies
  • Humans
  • Male
  • Asymptomatic Diseases
  • von Willebrand Factor/analysis
  • Computed Tomography Angiography
  • Thrombosis/blood
  • Blood Coagulation
  • Prekallikrein/analysis
  • Biomarkers/blood
  • Female
  • Aged
  • Aortic Aneurysm, Abdominal/blood
  • Aortography/methods
  • Thrombin Time

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