Von Willebrand and Factor VIII Portosystemic Circulation Gradient in Cirrhosis: Implications for Portal Vein Thrombosis

Michael Praktiknjo, Jonel Trebicka, Roberto Carnevale, Daniele Pastori, Alexander Queck, Evaristo Ettorre, Francesco Violi

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Abstract

OBJECTIVES: Portal vein thrombosis seems to be dependent on local hypercoagulation and venous stasis; data regarding endothelial damage are lacking. METHODS: von Willebrad factor, a marker of endothelial damage/perturbation, factor VIII, and lipopolysaccharides (LPS) were studied in the portal and systemic circulation of 20 cirrhotic patients undergoing transjugular intrahepatic portosystemic procedure. RESULTS: von Willebrad factor, factor VIII, and LPS were higher in the portal compared with systemic circulation, with a significant correlation between LPS and the other 2 variables. DISCUSSION: Endothelial damage and hypercoagulation coexist in the portal tree of patients with cirrhosis, and both could contribute to portal vein thrombosis. LPS may be a potential trigger of endothelial damage.

Original languageEnglish
Article numbere00123
JournalClinical and Translational Gastroenterology
Volume11
Issue number2
ISSN2155-384X
DOIs
Publication statusPublished - 1. Feb 2020

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