Vitamin D deficiency in a European inflammatory bowel disease inception cohort

an Epi-IBD study

Stefania Chetcuti Zammit, Pierre Ellul, Giulia Girardin, Daniela Valpiani, Kári R Nielsen, Jóngerð Olsen, Adrian Goldis, Daniela Lazar, Olga Shonová, Marie Nováková, Shaji Sebastian, Emma Whitehead, Amalia Carmona, Jesus Martinez-Cadilla, Jens F Dahlerup, Adriana L H Kievit, Niels Thorsgaard, Konstantinos H Katsanos, Dimitrios K Christodoulou, Fernando Magro & 27 others Riina Salupere, Natalia Pedersen, Jens Kjeldsen, Katrine Carlsen, Kaimaklioti Ioannis, Daniel Bergemalm, Jonas Halfvarson, Dana Duricova, Martin Bortlik, Pekka Collin, Pia Oksanen, Gediminas Kiudelis, Limas Kupcinskas, Karen Kudsk, Vibeke Andersen, Colm O'Morain, Yvonne Bailey, Schwartz Doron, Odes Shmuel, Sven Almer, Naila Arebi, Ravi Misra, Silvija Čuković-Čavka, Marko Brinar, Pia Munkholm, Zsuzsanna Vegh, Johan Burisch

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

BACKGROUND: Serum vitamin D level is commonly low in patients with inflammatory bowel disease (IBD). Although there is a growing body of evidence that links low vitamin D level to certain aspects of IBD such as disease activity and quality of life, data on its prevalence and how it varies across disease phenotype, smoking status and treatment groups are still missing.

MATERIALS AND METHODS: Patients diagnosed with IBD between 2010 and 2011 were recruited. Demographic data and serum vitamin D levels were collected. Variance of vitamin D level was then assessed across different treatment groups, disease phenotype, disease activity and quality of life scores.

RESULTS: A total of 238 (55.9% male) patients were included. Overall, 79% of the patients had either insufficient or deficient levels of vitamin D at diagnosis. Patients needing corticosteroid treatment at 1 year had significantly lower vitamin D levels at diagnosis (median 36.0 nmol/l) (P=0.035). Harvey-Bradshaw Index (P=0.0001) and Simple Clinical Colitis Activity Index scores (P=0.0001) were significantly lower in patients with higher vitamin D level. Serum vitamin D level correlated significantly with SIBQ score (P=0.0001) and with multiple components of SF12. Smokers at diagnosis had the lowest vitamin D levels (vitamin D: 34 nmol/l; P=0.053).

CONCLUSION: This study demonstrates the high prevalence of low vitamin D levels in treatment-naive European IBD populations. Furthermore, it demonstrates the presence of low vitamin D levels in patients with IBD who smoke.

Original languageEnglish
JournalEuropean journal of gastroenterology & hepatology
Volume30
Issue number11
Pages (from-to)1297–1303
ISSN0954-691X
DOIs
Publication statusPublished - Nov 2018

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Inflammatory Bowel Diseases
Serum
Quality of Life
Colitis
Smoke
Adrenal Cortex Hormones
Smoking

Keywords

  • Adolescent
  • Adrenal Cortex Hormones/therapeutic use
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Inflammatory Agents/therapeutic use
  • Biomarkers/blood
  • Child
  • Europe/epidemiology
  • Female
  • Humans
  • Inflammatory Bowel Diseases/diagnosis
  • Male
  • Middle Aged
  • Prevalence
  • Quality of Life
  • Risk Factors
  • Severity of Illness Index
  • Smoking/adverse effects
  • Time Factors
  • Vitamin D Deficiency/blood
  • Vitamin D/blood
  • Young Adult

Cite this

Zammit, S. C., Ellul, P., Girardin, G., Valpiani, D., Nielsen, K. R., Olsen, J., ... Burisch, J. (2018). Vitamin D deficiency in a European inflammatory bowel disease inception cohort: an Epi-IBD study. European journal of gastroenterology & hepatology, 30(11), 1297–1303. https://doi.org/10.1097/MEG.0000000000001238
Zammit, Stefania Chetcuti ; Ellul, Pierre ; Girardin, Giulia ; Valpiani, Daniela ; Nielsen, Kári R ; Olsen, Jóngerð ; Goldis, Adrian ; Lazar, Daniela ; Shonová, Olga ; Nováková, Marie ; Sebastian, Shaji ; Whitehead, Emma ; Carmona, Amalia ; Martinez-Cadilla, Jesus ; Dahlerup, Jens F ; Kievit, Adriana L H ; Thorsgaard, Niels ; Katsanos, Konstantinos H ; Christodoulou, Dimitrios K ; Magro, Fernando ; Salupere, Riina ; Pedersen, Natalia ; Kjeldsen, Jens ; Carlsen, Katrine ; Ioannis, Kaimaklioti ; Bergemalm, Daniel ; Halfvarson, Jonas ; Duricova, Dana ; Bortlik, Martin ; Collin, Pekka ; Oksanen, Pia ; Kiudelis, Gediminas ; Kupcinskas, Limas ; Kudsk, Karen ; Andersen, Vibeke ; O'Morain, Colm ; Bailey, Yvonne ; Doron, Schwartz ; Shmuel, Odes ; Almer, Sven ; Arebi, Naila ; Misra, Ravi ; Čuković-Čavka, Silvija ; Brinar, Marko ; Munkholm, Pia ; Vegh, Zsuzsanna ; Burisch, Johan. / Vitamin D deficiency in a European inflammatory bowel disease inception cohort : an Epi-IBD study. In: European journal of gastroenterology & hepatology. 2018 ; Vol. 30, No. 11. pp. 1297–1303.
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abstract = "BACKGROUND: Serum vitamin D level is commonly low in patients with inflammatory bowel disease (IBD). Although there is a growing body of evidence that links low vitamin D level to certain aspects of IBD such as disease activity and quality of life, data on its prevalence and how it varies across disease phenotype, smoking status and treatment groups are still missing.MATERIALS AND METHODS: Patients diagnosed with IBD between 2010 and 2011 were recruited. Demographic data and serum vitamin D levels were collected. Variance of vitamin D level was then assessed across different treatment groups, disease phenotype, disease activity and quality of life scores.RESULTS: A total of 238 (55.9{\%} male) patients were included. Overall, 79{\%} of the patients had either insufficient or deficient levels of vitamin D at diagnosis. Patients needing corticosteroid treatment at 1 year had significantly lower vitamin D levels at diagnosis (median 36.0 nmol/l) (P=0.035). Harvey-Bradshaw Index (P=0.0001) and Simple Clinical Colitis Activity Index scores (P=0.0001) were significantly lower in patients with higher vitamin D level. Serum vitamin D level correlated significantly with SIBQ score (P=0.0001) and with multiple components of SF12. Smokers at diagnosis had the lowest vitamin D levels (vitamin D: 34 nmol/l; P=0.053).CONCLUSION: This study demonstrates the high prevalence of low vitamin D levels in treatment-naive European IBD populations. Furthermore, it demonstrates the presence of low vitamin D levels in patients with IBD who smoke.",
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author = "Zammit, {Stefania Chetcuti} and Pierre Ellul and Giulia Girardin and Daniela Valpiani and Nielsen, {K{\'a}ri R} and J{\'o}nger{\dh} Olsen and Adrian Goldis and Daniela Lazar and Olga Shonov{\'a} and Marie Nov{\'a}kov{\'a} and Shaji Sebastian and Emma Whitehead and Amalia Carmona and Jesus Martinez-Cadilla and Dahlerup, {Jens F} and Kievit, {Adriana L H} and Niels Thorsgaard and Katsanos, {Konstantinos H} and Christodoulou, {Dimitrios K} and Fernando Magro and Riina Salupere and Natalia Pedersen and Jens Kjeldsen and Katrine Carlsen and Kaimaklioti Ioannis and Daniel Bergemalm and Jonas Halfvarson and Dana Duricova and Martin Bortlik and Pekka Collin and Pia Oksanen and Gediminas Kiudelis and Limas Kupcinskas and Karen Kudsk and Vibeke Andersen and Colm O'Morain and Yvonne Bailey and Schwartz Doron and Odes Shmuel and Sven Almer and Naila Arebi and Ravi Misra and Silvija Čuković-Čavka and Marko Brinar and Pia Munkholm and Zsuzsanna Vegh and Johan Burisch",
year = "2018",
month = "11",
doi = "10.1097/MEG.0000000000001238",
language = "English",
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pages = "1297–1303",
journal = "European Journal of Gastroenterology and Hepatology",
issn = "0954-691X",
publisher = "Lippincott Williams & Wilkins, Ltd.",
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Zammit, SC, Ellul, P, Girardin, G, Valpiani, D, Nielsen, KR, Olsen, J, Goldis, A, Lazar, D, Shonová, O, Nováková, M, Sebastian, S, Whitehead, E, Carmona, A, Martinez-Cadilla, J, Dahlerup, JF, Kievit, ALH, Thorsgaard, N, Katsanos, KH, Christodoulou, DK, Magro, F, Salupere, R, Pedersen, N, Kjeldsen, J, Carlsen, K, Ioannis, K, Bergemalm, D, Halfvarson, J, Duricova, D, Bortlik, M, Collin, P, Oksanen, P, Kiudelis, G, Kupcinskas, L, Kudsk, K, Andersen, V, O'Morain, C, Bailey, Y, Doron, S, Shmuel, O, Almer, S, Arebi, N, Misra, R, Čuković-Čavka, S, Brinar, M, Munkholm, P, Vegh, Z & Burisch, J 2018, 'Vitamin D deficiency in a European inflammatory bowel disease inception cohort: an Epi-IBD study', European journal of gastroenterology & hepatology, vol. 30, no. 11, pp. 1297–1303. https://doi.org/10.1097/MEG.0000000000001238

Vitamin D deficiency in a European inflammatory bowel disease inception cohort : an Epi-IBD study. / Zammit, Stefania Chetcuti; Ellul, Pierre; Girardin, Giulia; Valpiani, Daniela; Nielsen, Kári R; Olsen, Jóngerð; Goldis, Adrian; Lazar, Daniela; Shonová, Olga; Nováková, Marie; Sebastian, Shaji; Whitehead, Emma; Carmona, Amalia; Martinez-Cadilla, Jesus; Dahlerup, Jens F; Kievit, Adriana L H; Thorsgaard, Niels; Katsanos, Konstantinos H; Christodoulou, Dimitrios K; Magro, Fernando; Salupere, Riina; Pedersen, Natalia; Kjeldsen, Jens; Carlsen, Katrine; Ioannis, Kaimaklioti; Bergemalm, Daniel; Halfvarson, Jonas; Duricova, Dana; Bortlik, Martin; Collin, Pekka; Oksanen, Pia; Kiudelis, Gediminas; Kupcinskas, Limas; Kudsk, Karen; Andersen, Vibeke; O'Morain, Colm; Bailey, Yvonne; Doron, Schwartz; Shmuel, Odes; Almer, Sven; Arebi, Naila; Misra, Ravi; Čuković-Čavka, Silvija; Brinar, Marko; Munkholm, Pia; Vegh, Zsuzsanna; Burisch, Johan.

In: European journal of gastroenterology & hepatology, Vol. 30, No. 11, 11.2018, p. 1297–1303.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Vitamin D deficiency in a European inflammatory bowel disease inception cohort

T2 - an Epi-IBD study

AU - Zammit, Stefania Chetcuti

AU - Ellul, Pierre

AU - Girardin, Giulia

AU - Valpiani, Daniela

AU - Nielsen, Kári R

AU - Olsen, Jóngerð

AU - Goldis, Adrian

AU - Lazar, Daniela

AU - Shonová, Olga

AU - Nováková, Marie

AU - Sebastian, Shaji

AU - Whitehead, Emma

AU - Carmona, Amalia

AU - Martinez-Cadilla, Jesus

AU - Dahlerup, Jens F

AU - Kievit, Adriana L H

AU - Thorsgaard, Niels

AU - Katsanos, Konstantinos H

AU - Christodoulou, Dimitrios K

AU - Magro, Fernando

AU - Salupere, Riina

AU - Pedersen, Natalia

AU - Kjeldsen, Jens

AU - Carlsen, Katrine

AU - Ioannis, Kaimaklioti

AU - Bergemalm, Daniel

AU - Halfvarson, Jonas

AU - Duricova, Dana

AU - Bortlik, Martin

AU - Collin, Pekka

AU - Oksanen, Pia

AU - Kiudelis, Gediminas

AU - Kupcinskas, Limas

AU - Kudsk, Karen

AU - Andersen, Vibeke

AU - O'Morain, Colm

AU - Bailey, Yvonne

AU - Doron, Schwartz

AU - Shmuel, Odes

AU - Almer, Sven

AU - Arebi, Naila

AU - Misra, Ravi

AU - Čuković-Čavka, Silvija

AU - Brinar, Marko

AU - Munkholm, Pia

AU - Vegh, Zsuzsanna

AU - Burisch, Johan

PY - 2018/11

Y1 - 2018/11

N2 - BACKGROUND: Serum vitamin D level is commonly low in patients with inflammatory bowel disease (IBD). Although there is a growing body of evidence that links low vitamin D level to certain aspects of IBD such as disease activity and quality of life, data on its prevalence and how it varies across disease phenotype, smoking status and treatment groups are still missing.MATERIALS AND METHODS: Patients diagnosed with IBD between 2010 and 2011 were recruited. Demographic data and serum vitamin D levels were collected. Variance of vitamin D level was then assessed across different treatment groups, disease phenotype, disease activity and quality of life scores.RESULTS: A total of 238 (55.9% male) patients were included. Overall, 79% of the patients had either insufficient or deficient levels of vitamin D at diagnosis. Patients needing corticosteroid treatment at 1 year had significantly lower vitamin D levels at diagnosis (median 36.0 nmol/l) (P=0.035). Harvey-Bradshaw Index (P=0.0001) and Simple Clinical Colitis Activity Index scores (P=0.0001) were significantly lower in patients with higher vitamin D level. Serum vitamin D level correlated significantly with SIBQ score (P=0.0001) and with multiple components of SF12. Smokers at diagnosis had the lowest vitamin D levels (vitamin D: 34 nmol/l; P=0.053).CONCLUSION: This study demonstrates the high prevalence of low vitamin D levels in treatment-naive European IBD populations. Furthermore, it demonstrates the presence of low vitamin D levels in patients with IBD who smoke.

AB - BACKGROUND: Serum vitamin D level is commonly low in patients with inflammatory bowel disease (IBD). Although there is a growing body of evidence that links low vitamin D level to certain aspects of IBD such as disease activity and quality of life, data on its prevalence and how it varies across disease phenotype, smoking status and treatment groups are still missing.MATERIALS AND METHODS: Patients diagnosed with IBD between 2010 and 2011 were recruited. Demographic data and serum vitamin D levels were collected. Variance of vitamin D level was then assessed across different treatment groups, disease phenotype, disease activity and quality of life scores.RESULTS: A total of 238 (55.9% male) patients were included. Overall, 79% of the patients had either insufficient or deficient levels of vitamin D at diagnosis. Patients needing corticosteroid treatment at 1 year had significantly lower vitamin D levels at diagnosis (median 36.0 nmol/l) (P=0.035). Harvey-Bradshaw Index (P=0.0001) and Simple Clinical Colitis Activity Index scores (P=0.0001) were significantly lower in patients with higher vitamin D level. Serum vitamin D level correlated significantly with SIBQ score (P=0.0001) and with multiple components of SF12. Smokers at diagnosis had the lowest vitamin D levels (vitamin D: 34 nmol/l; P=0.053).CONCLUSION: This study demonstrates the high prevalence of low vitamin D levels in treatment-naive European IBD populations. Furthermore, it demonstrates the presence of low vitamin D levels in patients with IBD who smoke.

KW - Adolescent

KW - Adrenal Cortex Hormones/therapeutic use

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Anti-Inflammatory Agents/therapeutic use

KW - Biomarkers/blood

KW - Child

KW - Europe/epidemiology

KW - Female

KW - Humans

KW - Inflammatory Bowel Diseases/diagnosis

KW - Male

KW - Middle Aged

KW - Prevalence

KW - Quality of Life

KW - Risk Factors

KW - Severity of Illness Index

KW - Smoking/adverse effects

KW - Time Factors

KW - Vitamin D Deficiency/blood

KW - Vitamin D/blood

KW - Young Adult

U2 - 10.1097/MEG.0000000000001238

DO - 10.1097/MEG.0000000000001238

M3 - Journal article

VL - 30

SP - 1297

EP - 1303

JO - European Journal of Gastroenterology and Hepatology

JF - European Journal of Gastroenterology and Hepatology

SN - 0954-691X

IS - 11

ER -