"Visualization" of pain using cerebral 18F-FDG PET/CT following surgical treatment of lumbar disc herniation

Christian Christensen Støttrup; Caius Holst Mortensen; Reza Piri; Mohsen Khosravi; Andrew Newberg; Mikkel Østerheden Andersen; Abass Alavi; Peter Grupe; Poul Flemming Høilund-Carlsen

doi:10.1007/s00586-022-07442-1

"Visualization" of pain using cerebral 18F-FDG PET/CT following surgical treatment of lumbar disc herniation

Christian Christensen Støttrup, Caius Holst Mortensen, Reza Piri, Mohsen Khosravi, Andrew Newberg, Mikkel Østerheden Andersen, Abass Alavi, Peter Grupe, Poul Flemming Høilund-Carlsen^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

PURPOSE: We hypothesized that unilateral leg pain following surgical treatment of lumbar disc herniation (LDH) is associated with an increase in the glucose metabolism of the contralateral thalamus.

METHODS: Patients scheduled for surgery due to LDH underwent 18F-fluorodeoxyglucose positron emission tomography/computed tomography less than two weeks prior to surgery. Their thalamic FDG uptake was measured and expressed as the mean and partial volume corrected mean standardized uptake values (SUVmean and cSUVmean). These measures were compared with patient-related outcome measures collected pre- and 1-year post-operatively: back and leg pain on a 0-100 VAS scale and health-related quality of life as measured by the EuroQol-5D (EQ-5D).

RESULTS: Twenty-six patients (ten females) aged 49.7 ± 7.4 (mean ± SD) years were included. There was a significant correlation between painful body side and increased contralateral thalamic uptake of FDG, with regard to cSUVmean values. Correlation analyses including clinical parameters and cSUVmean indicated some association with 1-year change in EQ-5D.

CONCLUSION: These preliminary data sustain the hypothesis that unilateral pain in patients with LDH is associated with increased glucose metabolism in the contralateral thalamus, suggesting a central role of thalamus in chronic pain perception.

Original language	English
Journal	European Spine Journal
Volume	32
Issue number	2
Pages (from-to)	555-561
ISSN	0940-6719
DOIs	https://doi.org/10.1007/s00586-022-07442-1
Publication status	Published - Feb 2023

Keywords

18F-FDG
Lumbar disc herniation
PET
Pain
Pain perception
Quantification
Thalamus
Lumbar Vertebrae/diagnostic imaging
Humans
Treatment Outcome
Glucose
Intervertebral Disc Displacement/complications
Positron Emission Tomography Computed Tomography
Chronic Pain/complications
Quality of Life
Female
Fluorodeoxyglucose F18

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10.1007/s00586-022-07442-1

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1 Ph.D. thesis

Quantitative Sensory Testing and PET/CT Scanning in Assessment of Surgical Outcome for Lumbar Disc Herniation
Støttrup, C. C., Feb 2020, Syddansk Universitet. Det Sundhedsvidenskabelige Fakultet. 120 p.
Research output: Thesis › Ph.D. thesis

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title = "{"}Visualization{"} of pain using cerebral 18F-FDG PET/CT following surgical treatment of lumbar disc herniation",

abstract = "PURPOSE: We hypothesized that unilateral leg pain following surgical treatment of lumbar disc herniation (LDH) is associated with an increase in the glucose metabolism of the contralateral thalamus.METHODS: Patients scheduled for surgery due to LDH underwent 18F-fluorodeoxyglucose positron emission tomography/computed tomography less than two weeks prior to surgery. Their thalamic FDG uptake was measured and expressed as the mean and partial volume corrected mean standardized uptake values (SUVmean and cSUVmean). These measures were compared with patient-related outcome measures collected pre- and 1-year post-operatively: back and leg pain on a 0-100 VAS scale and health-related quality of life as measured by the EuroQol-5D (EQ-5D).RESULTS: Twenty-six patients (ten females) aged 49.7 ± 7.4 (mean ± SD) years were included. There was a significant correlation between painful body side and increased contralateral thalamic uptake of FDG, with regard to cSUVmean values. Correlation analyses including clinical parameters and cSUVmean indicated some association with 1-year change in EQ-5D.CONCLUSION: These preliminary data sustain the hypothesis that unilateral pain in patients with LDH is associated with increased glucose metabolism in the contralateral thalamus, suggesting a central role of thalamus in chronic pain perception.",

keywords = "18F-FDG, Lumbar disc herniation, PET, Pain, Pain perception, Quantification, Thalamus, Lumbar Vertebrae/diagnostic imaging, Humans, Treatment Outcome, Glucose, Intervertebral Disc Displacement/complications, Positron Emission Tomography Computed Tomography, Chronic Pain/complications, Quality of Life, Female, Fluorodeoxyglucose F18",

author = "St{\o}ttrup, {Christian Christensen} and Mortensen, {Caius Holst} and Reza Piri and Mohsen Khosravi and Andrew Newberg and Andersen, {Mikkel {\O}sterheden} and Abass Alavi and Peter Grupe and H{\o}ilund-Carlsen, {Poul Flemming}",

note = "{\textcopyright} 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.",

year = "2023",

month = feb,

doi = "10.1007/s00586-022-07442-1",

language = "English",

volume = "32",

pages = "555--561",

journal = "European Spine Journal",

issn = "0940-6719",

publisher = "Springer",

number = "2",

}

TY - JOUR

T1 - "Visualization" of pain using cerebral 18F-FDG PET/CT following surgical treatment of lumbar disc herniation

AU - Støttrup, Christian Christensen

AU - Mortensen, Caius Holst

AU - Piri, Reza

AU - Khosravi, Mohsen

AU - Newberg, Andrew

AU - Andersen, Mikkel Østerheden

AU - Alavi, Abass

AU - Grupe, Peter

AU - Høilund-Carlsen, Poul Flemming

PY - 2023/2

Y1 - 2023/2

N2 - PURPOSE: We hypothesized that unilateral leg pain following surgical treatment of lumbar disc herniation (LDH) is associated with an increase in the glucose metabolism of the contralateral thalamus.METHODS: Patients scheduled for surgery due to LDH underwent 18F-fluorodeoxyglucose positron emission tomography/computed tomography less than two weeks prior to surgery. Their thalamic FDG uptake was measured and expressed as the mean and partial volume corrected mean standardized uptake values (SUVmean and cSUVmean). These measures were compared with patient-related outcome measures collected pre- and 1-year post-operatively: back and leg pain on a 0-100 VAS scale and health-related quality of life as measured by the EuroQol-5D (EQ-5D).RESULTS: Twenty-six patients (ten females) aged 49.7 ± 7.4 (mean ± SD) years were included. There was a significant correlation between painful body side and increased contralateral thalamic uptake of FDG, with regard to cSUVmean values. Correlation analyses including clinical parameters and cSUVmean indicated some association with 1-year change in EQ-5D.CONCLUSION: These preliminary data sustain the hypothesis that unilateral pain in patients with LDH is associated with increased glucose metabolism in the contralateral thalamus, suggesting a central role of thalamus in chronic pain perception.

AB - PURPOSE: We hypothesized that unilateral leg pain following surgical treatment of lumbar disc herniation (LDH) is associated with an increase in the glucose metabolism of the contralateral thalamus.METHODS: Patients scheduled for surgery due to LDH underwent 18F-fluorodeoxyglucose positron emission tomography/computed tomography less than two weeks prior to surgery. Their thalamic FDG uptake was measured and expressed as the mean and partial volume corrected mean standardized uptake values (SUVmean and cSUVmean). These measures were compared with patient-related outcome measures collected pre- and 1-year post-operatively: back and leg pain on a 0-100 VAS scale and health-related quality of life as measured by the EuroQol-5D (EQ-5D).RESULTS: Twenty-six patients (ten females) aged 49.7 ± 7.4 (mean ± SD) years were included. There was a significant correlation between painful body side and increased contralateral thalamic uptake of FDG, with regard to cSUVmean values. Correlation analyses including clinical parameters and cSUVmean indicated some association with 1-year change in EQ-5D.CONCLUSION: These preliminary data sustain the hypothesis that unilateral pain in patients with LDH is associated with increased glucose metabolism in the contralateral thalamus, suggesting a central role of thalamus in chronic pain perception.

KW - 18F-FDG

KW - Lumbar disc herniation

KW - PET

KW - Pain

KW - Pain perception

KW - Quantification

KW - Thalamus

KW - Lumbar Vertebrae/diagnostic imaging

KW - Humans

KW - Treatment Outcome

KW - Glucose

KW - Intervertebral Disc Displacement/complications

KW - Positron Emission Tomography Computed Tomography

KW - Chronic Pain/complications

KW - Quality of Life

KW - Female

KW - Fluorodeoxyglucose F18

U2 - 10.1007/s00586-022-07442-1

DO - 10.1007/s00586-022-07442-1

M3 - Journal article

C2 - 36371750

SN - 0940-6719

VL - 32

SP - 555

EP - 561

JO - European Spine Journal

JF - European Spine Journal

IS - 2

ER -

"Visualization" of pain using cerebral 18F-FDG PET/CT following surgical treatment of lumbar disc herniation

Abstract

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Related research output

Quantitative Sensory Testing and PET/CT Scanning in Assessment of Surgical Outcome for Lumbar Disc Herniation

Cite this