Variability of plasma proteins according to molecular size. Long-term and short-term intra-individual variation

P. Hyltoft Petersen*, U. Feldt-Rasmussen, M. Hørder, O. Blaabjerg, K. Thygesen

*Corresponding author for this work

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The intra-individual variations in serum concentrations of α1-antitrypsin, albumin and α2-macroglobulin were determined using high precision analytical methods. The long-term (3 months) variations were 8.2 % for α1-antitrypsin and 2.9 % for α2-macroglobulin in five males and five females. The coefficients of variation for albumin were 1.5 and 3.4% for males and females, respectively. In males the long-term variations of albumin and α2-macroglobulin were highly correlated. The short-term (2 days) intra-individual variations in six males were 2.5, 3.8 and 3.4% for α1-antitrypsin, albumin and α2-macroglobulin respectively (coefficients of variation). A diurnal variation was found for albumin with maximal concentrations at 18.00 hours. At 6.00 and 10.00 hours the fractional concentrations of α1-antitrypsin and albumin were lower than for α1-macro-globulin. The variations of the three proteins were positively correlated.

Original languageEnglish
Book seriesScandinavian Journal of Clinical and Laboratory Investigation
Issue number2
Pages (from-to)143-150
Number of pages8
Publication statusPublished - 1. Jan 1981



  • Albumin
  • Diurnal variation
  • Individual vs analytical variation
  • Inter-protein variation
  • Sampling error
  • Specific protein analysis - high precision
  • Tourniquet

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