Validation of the UK myeloma research alliance risk profile, a new clinical prediction model for outcome in patients with newly diagnosed multiple myeloma not eligible for autologous stem cell transplantation: a population-based study from the Danish national multiple myeloma registry

Louise Redder*, Tobias W. Klausen, Annette Juul Vangsted, Henrik Gregersen, Niels F. Andersen, Robert S. Pedersen, Agoston G. Szabo, Mikael Frederiksen, Ulf C. Frølund, Carsten Helleberg, Lene Kongsgaard Nielsen, Per T. Pedersen, Morten Salomo, Peter Gimsing, Henrik Frederiksen, Niels Abildgaard

*Corresponding author for this work

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Abstract

In 2019 the UK Myeloma Research Alliance introduced the Myeloma Risk Profile (MRP) for prediction of outcome in patients with newly diagnosed multiple myeloma (MM), ineligible for autologous stem cell transplantation. To validate the MRP in a population-based setting we performed a study of the entire cohort of transplant ineligible MM patients above 65 years in the Danish National MM Registry. Our data confirmed the value of the MRP. In a cohort of 1,377 patients, the MRP score separated patients into three distinct risk-groups with an observed hazard ratio of 2.91 for early death in high-risk versus low-risk patients.

Original languageEnglish
JournalBritish Journal of Haematology
Volume193
Issue number1
Pages (from-to)119-124
ISSN0007-1048
DOIs
Publication statusPublished - Apr 2021

Keywords

  • geriatric
  • multiple myeloma
  • Myeloma Risk Profile
  • prognosis
  • survival

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