Usefulness of Cochrane Reviews in Clinical Guideline Development-A Survey of 585 Recommendations

Christoffer Bruun Korfitsen, Marie-Louise Kirkegaard Mikkelsen, Anja Ussing, Karen Christina Walker, Jeanett Friis Rohde, Henning Keinke Andersen, Simon Tarp, Mina Nicole Händel

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

The Danish Health Authority develops clinical practice guidelines to support clinical decision-making based on the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system and prioritizes using Cochrane reviews. The objective of this study was to explore the usefulness of Cochrane reviews as a source of evidence in the development of clinical recommendations. Evidence-based recommendations in guidelines published by the Danish Health Authority between 2014 and 2021 were reviewed. For each recommendation, it was noted if and how Cochrane reviews were utilized. In total, 374 evidence-based recommendations and 211 expert consensus recommendations were published between 2014 and 2021. Of the 374 evidence-based recommendations, 107 included evidence from Cochrane reviews. In 29 recommendations, all critical and important outcomes included evidence from Cochrane reviews. In 36 recommendations, a minimum of all critical outcomes included evidence from Cochrane reviews, but not all important outcomes. In 33 recommendations, some but not all critical outcomes included evidence from Cochrane reviews. Finally, in nine recommendations, some of the important outcomes included evidence from Cochrane reviews. In almost one-third of the evidence-based recommendations, Cochrane reviews were used to inform clinical recommendations. This evaluation should inform future evaluations of Cochrane review uptake in clinical practice guidelines concerning outcomes important for clinical decision-making.

Original languageEnglish
Article number685
JournalInternational Journal of Environmental Research and Public Health
Volume19
Issue number2
ISSN1661-7827
DOIs
Publication statusPublished - 7. Jan 2022
Externally publishedYes

Keywords

  • Clinical practice guideline
  • Cochrane
  • Core outcome set
  • GRADE
  • Systematic review

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