Use of soluble trem2 as a non-invasive biomarker for non-alcoholic steatohepatitis (NASH)

Niels Jonas Heilskov Graversen; Vineesh Indira Chandran; Søren Kragh Moestrup; Maria Kløjgaard Skytthe; Aleksander Ahm Krag; Charlotte Wernberg; Mette Enok Munk Lauridsen

Use of soluble trem2 as a non-invasive biomarker for non-alcoholic steatohepatitis (NASH)

Niels Jonas Heilskov Graversen (Inventor), Vineesh Indira Chandran (Inventor), Søren Kragh Moestrup (Inventor), Maria Kløjgaard Skytthe (Inventor), Aleksander Ahm Krag (Inventor), Charlotte Wernberg (Inventor), Mette Enok Munk Lauridsen (Inventor)

Ukendt

Research output: Patent

Abstract

Reliable non-invasive biomarkers are an unmet clinical need for the diagnosis of NASH patients. Herein we identify soluble TREM2 as a non-invasive plasma biomarker to diagnose NASH in obese patients and provides evidence for sTREM2 as an accurate predictor of advanced hepatic inflammation, ballooning, and fibrosis.

Original language	English
IPC	G01N 33/ 68
Patent number	WO2022248363
Country/Territory	Denmark
Priority date	28/05/2021
Priority number	EP20210176575
Publication status	Published - 1. Dec 2022

Cite this

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title = "Use of soluble trem2 as a non-invasive biomarker for non-alcoholic steatohepatitis (NASH)",

abstract = "Reliable non-invasive biomarkers are an unmet clinical need for the diagnosis of NASH patients. Herein we identify soluble TREM2 as a non-invasive plasma biomarker to diagnose NASH in obese patients and provides evidence for sTREM2 as an accurate predictor of advanced hepatic inflammation, ballooning, and fibrosis.",

author = "Graversen, {Niels Jonas Heilskov} and Chandran, {Vineesh Indira} and Moestrup, {S{\o}ren Kragh} and Skytthe, {Maria Kl{\o}jgaard} and Krag, {Aleksander Ahm} and Charlotte Wernberg and Lauridsen, {Mette Enok Munk}",

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T1 - Use of soluble trem2 as a non-invasive biomarker for non-alcoholic steatohepatitis (NASH)

AU - Graversen, Niels Jonas Heilskov

AU - Chandran, Vineesh Indira

AU - Moestrup, Søren Kragh

AU - Skytthe, Maria Kløjgaard

AU - Krag, Aleksander Ahm

AU - Wernberg, Charlotte

AU - Lauridsen, Mette Enok Munk

PY - 2022/12/1

Y1 - 2022/12/1

N2 - Reliable non-invasive biomarkers are an unmet clinical need for the diagnosis of NASH patients. Herein we identify soluble TREM2 as a non-invasive plasma biomarker to diagnose NASH in obese patients and provides evidence for sTREM2 as an accurate predictor of advanced hepatic inflammation, ballooning, and fibrosis.

AB - Reliable non-invasive biomarkers are an unmet clinical need for the diagnosis of NASH patients. Herein we identify soluble TREM2 as a non-invasive plasma biomarker to diagnose NASH in obese patients and provides evidence for sTREM2 as an accurate predictor of advanced hepatic inflammation, ballooning, and fibrosis.

M3 - Patent

M1 - WO2022248363

ER -

Use of soluble trem2 as a non-invasive biomarker for non-alcoholic steatohepatitis (NASH)

Abstract

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