Use of proton pump inhibitors among Danish children

a 16-year register-based nationwide study

Ignacio Aznar-Lou*, Mette Reilev, Anders Bergh Lødrup, Maria Rubio-Valera, Peter Fentz Haastrup, Anton Pottegård

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Objectives: Proton pump inhibitors (PPI) are among the most frequently used drugs in the developed countries. In recent years, their use among children and adolescents has been on the increase. Guidelines recommend use for a period no longer than 4-8 weeks. The aim of this study was to describe time trends in prescribing patterns of PPI use among children, with emphasis on persistence to therapy. Methods: We used the Danish nationwide healthcare registries and identified all Danish children (0-17 years old) who were provided with a filled in PPI prescription between 2000 and 2015. Based on descriptive analyses, we reported trends over time in annual use, prevalent and incident users. Moreover, we evaluated persistence to treatment and doses used over time. Analyses were stratified by age groups (0-4, 5-11 and 12-17 years). Results: We identified 212 056 filled in PPI prescriptions prescribed to 78 489 children. The total annual use of PPIs among children increased eight times from 2000 to 2015. Omeprazole was most frequently used (60% of all use). The proportion of prevalent users increased from 0.1 in 2000 to 3.1 per 1000 children in 2015, while the rate of new users increased from 1.2 to 8.0 per 1000 child years. In general, persistence to PPIs was low: in the youngest age groups (14%), slightly more children were covered by treatment 12 months after the first prescription compared with the oldest age groups (5%). Conclusion: The use of PPIs among Danish children has increased substantially during the last 15 years. In general, treatment with PPIs among children was of short duration. Attention should be paid to indications and rationality behind initiation of therapy.

Original languageEnglish
JournalBasic & Clinical Pharmacology & Toxicology
Volume124
Issue number6
Pages (from-to)704-710
ISSN1742-7835
DOIs
Publication statusPublished - Jun 2019

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Proton Pump Inhibitors
Omeprazole
Prescriptions
Age Groups
Pharmaceutical Preparations
Developed Countries
Registries
Guidelines
Delivery of Health Care

Keywords

  • persistence
  • pharmacoepidemiology
  • prescription registry
  • prevalence
  • treatment patterns

Cite this

@article{36dad92aed18448289c3e6ee4f3143cd,
title = "Use of proton pump inhibitors among Danish children: a 16-year register-based nationwide study",
abstract = "Objectives: Proton pump inhibitors (PPI) are among the most frequently used drugs in the developed countries. In recent years, their use among children and adolescents has been on the increase. Guidelines recommend use for a period no longer than 4-8 weeks. The aim of this study was to describe time trends in prescribing patterns of PPI use among children, with emphasis on persistence to therapy. Methods: We used the Danish nationwide healthcare registries and identified all Danish children (0-17 years old) who were provided with a filled in PPI prescription between 2000 and 2015. Based on descriptive analyses, we reported trends over time in annual use, prevalent and incident users. Moreover, we evaluated persistence to treatment and doses used over time. Analyses were stratified by age groups (0-4, 5-11 and 12-17 years). Results: We identified 212 056 filled in PPI prescriptions prescribed to 78 489 children. The total annual use of PPIs among children increased eight times from 2000 to 2015. Omeprazole was most frequently used (60{\%} of all use). The proportion of prevalent users increased from 0.1 in 2000 to 3.1 per 1000 children in 2015, while the rate of new users increased from 1.2 to 8.0 per 1000 child years. In general, persistence to PPIs was low: in the youngest age groups (14{\%}), slightly more children were covered by treatment 12 months after the first prescription compared with the oldest age groups (5{\%}). Conclusion: The use of PPIs among Danish children has increased substantially during the last 15 years. In general, treatment with PPIs among children was of short duration. Attention should be paid to indications and rationality behind initiation of therapy.",
keywords = "persistence, pharmacoepidemiology, prescription registry, prevalence, treatment patterns",
author = "Ignacio Aznar-Lou and Mette Reilev and L{\o}drup, {Anders Bergh} and Maria Rubio-Valera and Haastrup, {Peter Fentz} and Anton Potteg{\aa}rd",
note = "This article is protected by copyright. All rights reserved.",
year = "2019",
month = "6",
doi = "10.1111/bcpt.13191",
language = "English",
volume = "124",
pages = "704--710",
journal = "Basic & Clinical Pharmacology & Toxicology",
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publisher = "Wiley-Blackwell",
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}

Use of proton pump inhibitors among Danish children : a 16-year register-based nationwide study. / Aznar-Lou, Ignacio; Reilev, Mette; Lødrup, Anders Bergh; Rubio-Valera, Maria; Haastrup, Peter Fentz; Pottegård, Anton.

In: Basic & Clinical Pharmacology & Toxicology, Vol. 124, No. 6, 06.2019, p. 704-710.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Use of proton pump inhibitors among Danish children

T2 - a 16-year register-based nationwide study

AU - Aznar-Lou, Ignacio

AU - Reilev, Mette

AU - Lødrup, Anders Bergh

AU - Rubio-Valera, Maria

AU - Haastrup, Peter Fentz

AU - Pottegård, Anton

N1 - This article is protected by copyright. All rights reserved.

PY - 2019/6

Y1 - 2019/6

N2 - Objectives: Proton pump inhibitors (PPI) are among the most frequently used drugs in the developed countries. In recent years, their use among children and adolescents has been on the increase. Guidelines recommend use for a period no longer than 4-8 weeks. The aim of this study was to describe time trends in prescribing patterns of PPI use among children, with emphasis on persistence to therapy. Methods: We used the Danish nationwide healthcare registries and identified all Danish children (0-17 years old) who were provided with a filled in PPI prescription between 2000 and 2015. Based on descriptive analyses, we reported trends over time in annual use, prevalent and incident users. Moreover, we evaluated persistence to treatment and doses used over time. Analyses were stratified by age groups (0-4, 5-11 and 12-17 years). Results: We identified 212 056 filled in PPI prescriptions prescribed to 78 489 children. The total annual use of PPIs among children increased eight times from 2000 to 2015. Omeprazole was most frequently used (60% of all use). The proportion of prevalent users increased from 0.1 in 2000 to 3.1 per 1000 children in 2015, while the rate of new users increased from 1.2 to 8.0 per 1000 child years. In general, persistence to PPIs was low: in the youngest age groups (14%), slightly more children were covered by treatment 12 months after the first prescription compared with the oldest age groups (5%). Conclusion: The use of PPIs among Danish children has increased substantially during the last 15 years. In general, treatment with PPIs among children was of short duration. Attention should be paid to indications and rationality behind initiation of therapy.

AB - Objectives: Proton pump inhibitors (PPI) are among the most frequently used drugs in the developed countries. In recent years, their use among children and adolescents has been on the increase. Guidelines recommend use for a period no longer than 4-8 weeks. The aim of this study was to describe time trends in prescribing patterns of PPI use among children, with emphasis on persistence to therapy. Methods: We used the Danish nationwide healthcare registries and identified all Danish children (0-17 years old) who were provided with a filled in PPI prescription between 2000 and 2015. Based on descriptive analyses, we reported trends over time in annual use, prevalent and incident users. Moreover, we evaluated persistence to treatment and doses used over time. Analyses were stratified by age groups (0-4, 5-11 and 12-17 years). Results: We identified 212 056 filled in PPI prescriptions prescribed to 78 489 children. The total annual use of PPIs among children increased eight times from 2000 to 2015. Omeprazole was most frequently used (60% of all use). The proportion of prevalent users increased from 0.1 in 2000 to 3.1 per 1000 children in 2015, while the rate of new users increased from 1.2 to 8.0 per 1000 child years. In general, persistence to PPIs was low: in the youngest age groups (14%), slightly more children were covered by treatment 12 months after the first prescription compared with the oldest age groups (5%). Conclusion: The use of PPIs among Danish children has increased substantially during the last 15 years. In general, treatment with PPIs among children was of short duration. Attention should be paid to indications and rationality behind initiation of therapy.

KW - persistence

KW - pharmacoepidemiology

KW - prescription registry

KW - prevalence

KW - treatment patterns

U2 - 10.1111/bcpt.13191

DO - 10.1111/bcpt.13191

M3 - Journal article

VL - 124

SP - 704

EP - 710

JO - Basic & Clinical Pharmacology & Toxicology

JF - Basic & Clinical Pharmacology & Toxicology

SN - 1742-7835

IS - 6

ER -