Use of antibiotics for urinary tract infection in women undergoing surgery for urinary incontinence

a cohort study

Rikke Guldberg, Ulrik Schiøler Kesmodel, Søren Brostrøm, Linda Kærlev, Jesper Kjær Hansen, Jesper Hallas, Bente Mertz Nørgård

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

OBJECTIVE: To describe the use of antibiotics for urinary tract infection (UTI) before and after surgery for urinary incontinence (UI); and for those with use of antibiotics before surgery, to estimate the risk of treatment for a postoperative UTI, relative to those without use of antibiotics before surgery.

DESIGN: A historical population-based cohort study.

SETTING: Denmark.

PARTICIPANTS: Women (age ≥18 years) with a primary surgical procedure for UI from the county of Funen and the Region of Southern Denmark from 1996 throughout 2010. Data on redeemed prescriptions of antibiotics ±365 days from the date of surgery were extracted from a prescription database.

MAIN OUTCOME MEASURES: Use of antibiotics for UTI in relation to UI surgery, and the risk of being a postoperative user of antibiotics for UTI among preoperative users.

RESULTS: A total of 2151 women had a primary surgical procedure for UI; of these 496 (23.1%) were preoperative users of antibiotics for UTI. Among preoperative users, 129 (26%) and 215 (43.3%) also redeemed prescriptions of antibiotics for UTI within 0-60 and 61-365 days after surgery, respectively. Among preoperative non-users, 182 (11.0%) and 235 (14.2%) redeemed prescriptions within 0-60 and 61-365 days after surgery, respectively. Presurgery exposure to antibiotics for UTI was a strong risk factor for postoperative treatment for UTI, both within 0-60 days (adjusted OR, aOR=2.6 (95% CI 2.0 to 3.5)) and within 61-365 days (aOR=4.5 (95% CI 3.5 to 5.7)).

CONCLUSIONS: 1 in 4 women undergoing surgery for UI was treated for UTI before surgery, and half of them had a continuing tendency to UTIs after surgery. Use of antibiotics for UTI before surgery was a strong risk factor for antibiotic use after surgery. In women not using antibiotics for UTI before surgery only a minor proportion initiated use after surgery.

Original languageEnglish
Article numbere004051
JournalBMJ Open
Volume4
Issue number2
Number of pages9
ISSN2044-6055
DOIs
Publication statusPublished - 2014

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Cohort Studies
Prescriptions
Ambulatory Surgical Procedures
Denmark
Databases

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@article{277f4c2c68e949abae21cbf8469b5310,
title = "Use of antibiotics for urinary tract infection in women undergoing surgery for urinary incontinence: a cohort study",
abstract = "OBJECTIVE: To describe the use of antibiotics for urinary tract infection (UTI) before and after surgery for urinary incontinence (UI); and for those with use of antibiotics before surgery, to estimate the risk of treatment for a postoperative UTI, relative to those without use of antibiotics before surgery. DESIGN: A historical population-based cohort study. SETTING: Denmark. PARTICIPANTS: Women (age ≥18 years) with a primary surgical procedure for UI from the county of Funen and the Region of Southern Denmark from 1996 throughout 2010. Data on redeemed prescriptions of antibiotics ±365 days from the date of surgery were extracted from a prescription database. MAIN OUTCOME MEASURES: Use of antibiotics for UTI in relation to UI surgery, and the risk of being a postoperative user of antibiotics for UTI among preoperative users. RESULTS: A total of 2151 women had a primary surgical procedure for UI; of these 496 (23.1{\%}) were preoperative users of antibiotics for UTI. Among preoperative users, 129 (26{\%}) and 215 (43.3{\%}) also redeemed prescriptions of antibiotics for UTI within 0-60 and 61-365 days after surgery, respectively. Among preoperative non-users, 182 (11.0{\%}) and 235 (14.2{\%}) redeemed prescriptions within 0-60 and 61-365 days after surgery, respectively. Presurgery exposure to antibiotics for UTI was a strong risk factor for postoperative treatment for UTI, both within 0-60 days (adjusted OR, aOR=2.6 (95{\%} CI 2.0 to 3.5)) and within 61-365 days (aOR=4.5 (95{\%} CI 3.5 to 5.7)). CONCLUSIONS: 1 in 4 women undergoing surgery for UI was treated for UTI before surgery, and half of them had a continuing tendency to UTIs after surgery. Use of antibiotics for UTI before surgery was a strong risk factor for antibiotic use after surgery. In women not using antibiotics for UTI before surgery only a minor proportion initiated use after surgery.",
author = "Rikke Guldberg and Kesmodel, {Ulrik Schi{\o}ler} and S{\o}ren Brostr{\o}m and Linda K{\ae}rlev and Hansen, {Jesper Kj{\ae}r} and Jesper Hallas and N{\o}rg{\aa}rd, {Bente Mertz}",
year = "2014",
doi = "10.1136/bmjopen-2013-004051",
language = "English",
volume = "4",
journal = "B M J Open",
issn = "2044-6055",
publisher = "BMJ Group",
number = "2",

}

Use of antibiotics for urinary tract infection in women undergoing surgery for urinary incontinence : a cohort study. / Guldberg, Rikke; Kesmodel, Ulrik Schiøler; Brostrøm, Søren; Kærlev, Linda; Hansen, Jesper Kjær; Hallas, Jesper; Nørgård, Bente Mertz.

In: BMJ Open, Vol. 4, No. 2, e004051, 2014.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Use of antibiotics for urinary tract infection in women undergoing surgery for urinary incontinence

T2 - a cohort study

AU - Guldberg, Rikke

AU - Kesmodel, Ulrik Schiøler

AU - Brostrøm, Søren

AU - Kærlev, Linda

AU - Hansen, Jesper Kjær

AU - Hallas, Jesper

AU - Nørgård, Bente Mertz

PY - 2014

Y1 - 2014

N2 - OBJECTIVE: To describe the use of antibiotics for urinary tract infection (UTI) before and after surgery for urinary incontinence (UI); and for those with use of antibiotics before surgery, to estimate the risk of treatment for a postoperative UTI, relative to those without use of antibiotics before surgery. DESIGN: A historical population-based cohort study. SETTING: Denmark. PARTICIPANTS: Women (age ≥18 years) with a primary surgical procedure for UI from the county of Funen and the Region of Southern Denmark from 1996 throughout 2010. Data on redeemed prescriptions of antibiotics ±365 days from the date of surgery were extracted from a prescription database. MAIN OUTCOME MEASURES: Use of antibiotics for UTI in relation to UI surgery, and the risk of being a postoperative user of antibiotics for UTI among preoperative users. RESULTS: A total of 2151 women had a primary surgical procedure for UI; of these 496 (23.1%) were preoperative users of antibiotics for UTI. Among preoperative users, 129 (26%) and 215 (43.3%) also redeemed prescriptions of antibiotics for UTI within 0-60 and 61-365 days after surgery, respectively. Among preoperative non-users, 182 (11.0%) and 235 (14.2%) redeemed prescriptions within 0-60 and 61-365 days after surgery, respectively. Presurgery exposure to antibiotics for UTI was a strong risk factor for postoperative treatment for UTI, both within 0-60 days (adjusted OR, aOR=2.6 (95% CI 2.0 to 3.5)) and within 61-365 days (aOR=4.5 (95% CI 3.5 to 5.7)). CONCLUSIONS: 1 in 4 women undergoing surgery for UI was treated for UTI before surgery, and half of them had a continuing tendency to UTIs after surgery. Use of antibiotics for UTI before surgery was a strong risk factor for antibiotic use after surgery. In women not using antibiotics for UTI before surgery only a minor proportion initiated use after surgery.

AB - OBJECTIVE: To describe the use of antibiotics for urinary tract infection (UTI) before and after surgery for urinary incontinence (UI); and for those with use of antibiotics before surgery, to estimate the risk of treatment for a postoperative UTI, relative to those without use of antibiotics before surgery. DESIGN: A historical population-based cohort study. SETTING: Denmark. PARTICIPANTS: Women (age ≥18 years) with a primary surgical procedure for UI from the county of Funen and the Region of Southern Denmark from 1996 throughout 2010. Data on redeemed prescriptions of antibiotics ±365 days from the date of surgery were extracted from a prescription database. MAIN OUTCOME MEASURES: Use of antibiotics for UTI in relation to UI surgery, and the risk of being a postoperative user of antibiotics for UTI among preoperative users. RESULTS: A total of 2151 women had a primary surgical procedure for UI; of these 496 (23.1%) were preoperative users of antibiotics for UTI. Among preoperative users, 129 (26%) and 215 (43.3%) also redeemed prescriptions of antibiotics for UTI within 0-60 and 61-365 days after surgery, respectively. Among preoperative non-users, 182 (11.0%) and 235 (14.2%) redeemed prescriptions within 0-60 and 61-365 days after surgery, respectively. Presurgery exposure to antibiotics for UTI was a strong risk factor for postoperative treatment for UTI, both within 0-60 days (adjusted OR, aOR=2.6 (95% CI 2.0 to 3.5)) and within 61-365 days (aOR=4.5 (95% CI 3.5 to 5.7)). CONCLUSIONS: 1 in 4 women undergoing surgery for UI was treated for UTI before surgery, and half of them had a continuing tendency to UTIs after surgery. Use of antibiotics for UTI before surgery was a strong risk factor for antibiotic use after surgery. In women not using antibiotics for UTI before surgery only a minor proportion initiated use after surgery.

U2 - 10.1136/bmjopen-2013-004051

DO - 10.1136/bmjopen-2013-004051

M3 - Journal article

VL - 4

JO - B M J Open

JF - B M J Open

SN - 2044-6055

IS - 2

M1 - e004051

ER -