Ultrasound pathology of the entheses in an age and gender stratified sample of healthy adult subjects: a prospective cross-sectional frequency study

Jørgen Guldberg-Møller, Lene Terslev, Sabrina M Nielsen, Merete Juhl Kønig, Søren T Torp-Pedersen, Arendse Torp-Pedersen, Robin Christensen, Henning Bliddal, Karen Ellegaard

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

OBJECTIVES: Ultrasound (US) examination of the entheses is increasingly used. However, little is known about US findings in the entheses in asymptomatic persons. The aim of this study was to investigate the appearance of US signs in the enthuses of the lower limb in asymptomatic subjects.

METHODS: We recruited 64 subjects, eight women and eight men whose ages covered four decades, from 20 to 60 years. None had tendon or joint disease in the lower limbs. Participants were examined by a rheumatologist and blood samples were collected to rule out enthesis pathology. The enthesis of the dominant leg were examined with grey-scale and Doppler US to evaluate increased thickness, changed structure, enthesophytes/calcifications, erosions, and colour Doppler signal.

RESULTS: Ultrasound examination of 320 entheses was made. At enthesis level, elementary lesions were seen at 73 (22.8%) sites, at subject-level 47 (73.4%) persons showed elementary lesions, in 27 (57%) only one enthesis was affected. Doppler activity was seen in four sites, three at the quadriceps insertion. Most common US elementary lesion was enthesophytes at the Achilles and quadriceps tendon insertion. A tendency towards more elementary lesions was seen in men, and a slight increase was seen with increasing age, however, not statistically significance.

CONCLUSIONS: Our findings suggest that US can be used to diagnose/examine subjects in adulthood for pathological changes in the entheses; however, caution should be taken regarding enthesophytes of the quadriceps and Achilles tendon.

Original languageEnglish
JournalClinical and Experimental Rheumatology
Volume37
Issue number3
Pages (from-to)408-413
ISSN0392-856X
Publication statusPublished - 9. Jan 2019

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Achilles Tendon
Cross-Sectional Studies
Pathology
Doppler Ultrasonography
Joint Diseases
Leg
Color
Rheumatologists

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Guldberg-Møller, J., Terslev, L., Nielsen, S. M., Kønig, M. J., Torp-Pedersen, S. T., Torp-Pedersen, A., ... Ellegaard, K. (2019). Ultrasound pathology of the entheses in an age and gender stratified sample of healthy adult subjects: a prospective cross-sectional frequency study. Clinical and Experimental Rheumatology, 37(3), 408-413.
Guldberg-Møller, Jørgen ; Terslev, Lene ; Nielsen, Sabrina M ; Kønig, Merete Juhl ; Torp-Pedersen, Søren T ; Torp-Pedersen, Arendse ; Christensen, Robin ; Bliddal, Henning ; Ellegaard, Karen. / Ultrasound pathology of the entheses in an age and gender stratified sample of healthy adult subjects : a prospective cross-sectional frequency study. In: Clinical and Experimental Rheumatology. 2019 ; Vol. 37, No. 3. pp. 408-413.
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title = "Ultrasound pathology of the entheses in an age and gender stratified sample of healthy adult subjects: a prospective cross-sectional frequency study",
abstract = "OBJECTIVES: Ultrasound (US) examination of the entheses is increasingly used. However, little is known about US findings in the entheses in asymptomatic persons. The aim of this study was to investigate the appearance of US signs in the enthuses of the lower limb in asymptomatic subjects.METHODS: We recruited 64 subjects, eight women and eight men whose ages covered four decades, from 20 to 60 years. None had tendon or joint disease in the lower limbs. Participants were examined by a rheumatologist and blood samples were collected to rule out enthesis pathology. The enthesis of the dominant leg were examined with grey-scale and Doppler US to evaluate increased thickness, changed structure, enthesophytes/calcifications, erosions, and colour Doppler signal.RESULTS: Ultrasound examination of 320 entheses was made. At enthesis level, elementary lesions were seen at 73 (22.8{\%}) sites, at subject-level 47 (73.4{\%}) persons showed elementary lesions, in 27 (57{\%}) only one enthesis was affected. Doppler activity was seen in four sites, three at the quadriceps insertion. Most common US elementary lesion was enthesophytes at the Achilles and quadriceps tendon insertion. A tendency towards more elementary lesions was seen in men, and a slight increase was seen with increasing age, however, not statistically significance.CONCLUSIONS: Our findings suggest that US can be used to diagnose/examine subjects in adulthood for pathological changes in the entheses; however, caution should be taken regarding enthesophytes of the quadriceps and Achilles tendon.",
author = "J{\o}rgen Guldberg-M{\o}ller and Lene Terslev and Nielsen, {Sabrina M} and K{\o}nig, {Merete Juhl} and Torp-Pedersen, {S{\o}ren T} and Arendse Torp-Pedersen and Robin Christensen and Henning Bliddal and Karen Ellegaard",
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Guldberg-Møller, J, Terslev, L, Nielsen, SM, Kønig, MJ, Torp-Pedersen, ST, Torp-Pedersen, A, Christensen, R, Bliddal, H & Ellegaard, K 2019, 'Ultrasound pathology of the entheses in an age and gender stratified sample of healthy adult subjects: a prospective cross-sectional frequency study', Clinical and Experimental Rheumatology, vol. 37, no. 3, pp. 408-413.

Ultrasound pathology of the entheses in an age and gender stratified sample of healthy adult subjects : a prospective cross-sectional frequency study. / Guldberg-Møller, Jørgen; Terslev, Lene; Nielsen, Sabrina M; Kønig, Merete Juhl; Torp-Pedersen, Søren T; Torp-Pedersen, Arendse; Christensen, Robin; Bliddal, Henning; Ellegaard, Karen.

In: Clinical and Experimental Rheumatology, Vol. 37, No. 3, 09.01.2019, p. 408-413.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Ultrasound pathology of the entheses in an age and gender stratified sample of healthy adult subjects

T2 - a prospective cross-sectional frequency study

AU - Guldberg-Møller, Jørgen

AU - Terslev, Lene

AU - Nielsen, Sabrina M

AU - Kønig, Merete Juhl

AU - Torp-Pedersen, Søren T

AU - Torp-Pedersen, Arendse

AU - Christensen, Robin

AU - Bliddal, Henning

AU - Ellegaard, Karen

PY - 2019/1/9

Y1 - 2019/1/9

N2 - OBJECTIVES: Ultrasound (US) examination of the entheses is increasingly used. However, little is known about US findings in the entheses in asymptomatic persons. The aim of this study was to investigate the appearance of US signs in the enthuses of the lower limb in asymptomatic subjects.METHODS: We recruited 64 subjects, eight women and eight men whose ages covered four decades, from 20 to 60 years. None had tendon or joint disease in the lower limbs. Participants were examined by a rheumatologist and blood samples were collected to rule out enthesis pathology. The enthesis of the dominant leg were examined with grey-scale and Doppler US to evaluate increased thickness, changed structure, enthesophytes/calcifications, erosions, and colour Doppler signal.RESULTS: Ultrasound examination of 320 entheses was made. At enthesis level, elementary lesions were seen at 73 (22.8%) sites, at subject-level 47 (73.4%) persons showed elementary lesions, in 27 (57%) only one enthesis was affected. Doppler activity was seen in four sites, three at the quadriceps insertion. Most common US elementary lesion was enthesophytes at the Achilles and quadriceps tendon insertion. A tendency towards more elementary lesions was seen in men, and a slight increase was seen with increasing age, however, not statistically significance.CONCLUSIONS: Our findings suggest that US can be used to diagnose/examine subjects in adulthood for pathological changes in the entheses; however, caution should be taken regarding enthesophytes of the quadriceps and Achilles tendon.

AB - OBJECTIVES: Ultrasound (US) examination of the entheses is increasingly used. However, little is known about US findings in the entheses in asymptomatic persons. The aim of this study was to investigate the appearance of US signs in the enthuses of the lower limb in asymptomatic subjects.METHODS: We recruited 64 subjects, eight women and eight men whose ages covered four decades, from 20 to 60 years. None had tendon or joint disease in the lower limbs. Participants were examined by a rheumatologist and blood samples were collected to rule out enthesis pathology. The enthesis of the dominant leg were examined with grey-scale and Doppler US to evaluate increased thickness, changed structure, enthesophytes/calcifications, erosions, and colour Doppler signal.RESULTS: Ultrasound examination of 320 entheses was made. At enthesis level, elementary lesions were seen at 73 (22.8%) sites, at subject-level 47 (73.4%) persons showed elementary lesions, in 27 (57%) only one enthesis was affected. Doppler activity was seen in four sites, three at the quadriceps insertion. Most common US elementary lesion was enthesophytes at the Achilles and quadriceps tendon insertion. A tendency towards more elementary lesions was seen in men, and a slight increase was seen with increasing age, however, not statistically significance.CONCLUSIONS: Our findings suggest that US can be used to diagnose/examine subjects in adulthood for pathological changes in the entheses; however, caution should be taken regarding enthesophytes of the quadriceps and Achilles tendon.

M3 - Journal article

C2 - 30620269

VL - 37

SP - 408

EP - 413

JO - Clinical and Experimental Rheumatology

JF - Clinical and Experimental Rheumatology

SN - 0392-856X

IS - 3

ER -