Ultrasound-guided Lung Biopsy in the Hands of Respiratory Physicians: Diagnostic Yield and Complications in 215 Consecutive Patients in 3 Centers

Christian B. Laursen, Therese M.H. Naur, Uffe Bodtger, Sara Colella, Matiullah Naqibullah, Valentina Minddal, Lars Konge, Jesper Rømhild Davidsen, Niels-Christian Gerner Hansen, Ole Graumann, Paul F. Clementsen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Background: The aim of the study was to determine the diagnostic yield and prevalence of complications of ultrasound-guided transthoracic needle aspiration biopsies (US-TTNAB) performed by respiratory physicians after implementation of the procedure in an everyday clinical setting at 3 different centers. Methods: Patients were included if they during the period from January 2012 to August 2014 had a registered USTTNAB procedure code or if a US biopsy registration form had been filled out at either of the participating centers. Histology or cytology results were used as a reference test for diagnoses that could be made based on these results. Reference test for the remaining diagnoses was clinical follow-up. The diagnostic yield of USTTNAB was defined as the proportion of patients in which the result of the US-TTNAB was consistent with the reference test. Results: A total of 215 patients in which a primary USTTNAB had been performed were identified. The most common biopsy sites were lungs and pleurae with a total of 164 (76.3%) patients and 31 patients (14.4%), respectively. US-TTNAB diagnostic yield was 76.9% (95% CI, 70.3%-83.4%) for malignant diagnoses and 47.6% (95% CI, 31.9%-63.4%) for nonmalignant diagnoses. The most common complications of USTTNAB were pneumothorax (2.5%; 95% CI, 0.03%- 4.6%) and pain at the biopsy site (2%; 95% CI, 0.04%-3.9%). No fatalities related to US-TTNAB were observed. Conclusion: US-TTNAB performed by respiratory physicians is a safe procedure with a low risk of complications and the diagnostic yield to establish a malignant diagnosis is acceptable.
Original languageEnglish
JournalJournal of Bronchology & Interventional Pulmonology
Volume23
Issue number3
Pages (from-to)220-228
ISSN1944-6586
DOIs
Publication statusPublished - 1. Jul 2016

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Physicians
Lung
Pleura
Pneumothorax
Cell Biology

Keywords

  • Lung cancer
  • Pleura
  • Pleural Neoplasms
  • Ultrasound
  • ultrasound guided transthoracic needle aspiration biopsy
  • Diagnosis
  • Multicenter study
  • outpatient care

Cite this

@article{1b507f4354cb4d57adb2c3c9d003dc71,
title = "Ultrasound-guided Lung Biopsy in the Hands of Respiratory Physicians: Diagnostic Yield and Complications in 215 Consecutive Patients in 3 Centers",
abstract = "Background: The aim of the study was to determine the diagnostic yield and prevalence of complications of ultrasound-guided transthoracic needle aspiration biopsies (US-TTNAB) performed by respiratory physicians after implementation of the procedure in an everyday clinical setting at 3 different centers. Methods: Patients were included if they during the period from January 2012 to August 2014 had a registered USTTNAB procedure code or if a US biopsy registration form had been filled out at either of the participating centers. Histology or cytology results were used as a reference test for diagnoses that could be made based on these results. Reference test for the remaining diagnoses was clinical follow-up. The diagnostic yield of USTTNAB was defined as the proportion of patients in which the result of the US-TTNAB was consistent with the reference test. Results: A total of 215 patients in which a primary USTTNAB had been performed were identified. The most common biopsy sites were lungs and pleurae with a total of 164 (76.3{\%}) patients and 31 patients (14.4{\%}), respectively. US-TTNAB diagnostic yield was 76.9{\%} (95{\%} CI, 70.3{\%}-83.4{\%}) for malignant diagnoses and 47.6{\%} (95{\%} CI, 31.9{\%}-63.4{\%}) for nonmalignant diagnoses. The most common complications of USTTNAB were pneumothorax (2.5{\%}; 95{\%} CI, 0.03{\%}- 4.6{\%}) and pain at the biopsy site (2{\%}; 95{\%} CI, 0.04{\%}-3.9{\%}). No fatalities related to US-TTNAB were observed. Conclusion: US-TTNAB performed by respiratory physicians is a safe procedure with a low risk of complications and the diagnostic yield to establish a malignant diagnosis is acceptable.",
keywords = "Lung cancer, Pleura, Pleural Neoplasms, Ultrasound, ultrasound guided transthoracic needle aspiration biopsy, Diagnosis, Multicenter study, outpatient care",
author = "Laursen, {Christian B.} and Naur, {Therese M.H.} and Uffe Bodtger and Sara Colella and Matiullah Naqibullah and Valentina Minddal and Lars Konge and {R{\o}mhild Davidsen}, Jesper and Hansen, {Niels-Christian Gerner} and Ole Graumann and Clementsen, {Paul F.}",
year = "2016",
month = "7",
day = "1",
doi = "10.1097/LBR.0000000000000297",
language = "English",
volume = "23",
pages = "220--228",
journal = "Journal of Bronchology & Interventional Pulmonology",
issn = "1944-6586",
publisher = "Lippincott Williams & Wilkins",
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Ultrasound-guided Lung Biopsy in the Hands of Respiratory Physicians : Diagnostic Yield and Complications in 215 Consecutive Patients in 3 Centers. / Laursen, Christian B.; Naur, Therese M.H.; Bodtger, Uffe; Colella, Sara; Naqibullah, Matiullah; Minddal, Valentina; Konge, Lars; Rømhild Davidsen, Jesper; Hansen, Niels-Christian Gerner; Graumann, Ole; Clementsen, Paul F.

In: Journal of Bronchology & Interventional Pulmonology, Vol. 23, No. 3, 01.07.2016, p. 220-228.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Ultrasound-guided Lung Biopsy in the Hands of Respiratory Physicians

T2 - Diagnostic Yield and Complications in 215 Consecutive Patients in 3 Centers

AU - Laursen, Christian B.

AU - Naur, Therese M.H.

AU - Bodtger, Uffe

AU - Colella, Sara

AU - Naqibullah, Matiullah

AU - Minddal, Valentina

AU - Konge, Lars

AU - Rømhild Davidsen, Jesper

AU - Hansen, Niels-Christian Gerner

AU - Graumann, Ole

AU - Clementsen, Paul F.

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Background: The aim of the study was to determine the diagnostic yield and prevalence of complications of ultrasound-guided transthoracic needle aspiration biopsies (US-TTNAB) performed by respiratory physicians after implementation of the procedure in an everyday clinical setting at 3 different centers. Methods: Patients were included if they during the period from January 2012 to August 2014 had a registered USTTNAB procedure code or if a US biopsy registration form had been filled out at either of the participating centers. Histology or cytology results were used as a reference test for diagnoses that could be made based on these results. Reference test for the remaining diagnoses was clinical follow-up. The diagnostic yield of USTTNAB was defined as the proportion of patients in which the result of the US-TTNAB was consistent with the reference test. Results: A total of 215 patients in which a primary USTTNAB had been performed were identified. The most common biopsy sites were lungs and pleurae with a total of 164 (76.3%) patients and 31 patients (14.4%), respectively. US-TTNAB diagnostic yield was 76.9% (95% CI, 70.3%-83.4%) for malignant diagnoses and 47.6% (95% CI, 31.9%-63.4%) for nonmalignant diagnoses. The most common complications of USTTNAB were pneumothorax (2.5%; 95% CI, 0.03%- 4.6%) and pain at the biopsy site (2%; 95% CI, 0.04%-3.9%). No fatalities related to US-TTNAB were observed. Conclusion: US-TTNAB performed by respiratory physicians is a safe procedure with a low risk of complications and the diagnostic yield to establish a malignant diagnosis is acceptable.

AB - Background: The aim of the study was to determine the diagnostic yield and prevalence of complications of ultrasound-guided transthoracic needle aspiration biopsies (US-TTNAB) performed by respiratory physicians after implementation of the procedure in an everyday clinical setting at 3 different centers. Methods: Patients were included if they during the period from January 2012 to August 2014 had a registered USTTNAB procedure code or if a US biopsy registration form had been filled out at either of the participating centers. Histology or cytology results were used as a reference test for diagnoses that could be made based on these results. Reference test for the remaining diagnoses was clinical follow-up. The diagnostic yield of USTTNAB was defined as the proportion of patients in which the result of the US-TTNAB was consistent with the reference test. Results: A total of 215 patients in which a primary USTTNAB had been performed were identified. The most common biopsy sites were lungs and pleurae with a total of 164 (76.3%) patients and 31 patients (14.4%), respectively. US-TTNAB diagnostic yield was 76.9% (95% CI, 70.3%-83.4%) for malignant diagnoses and 47.6% (95% CI, 31.9%-63.4%) for nonmalignant diagnoses. The most common complications of USTTNAB were pneumothorax (2.5%; 95% CI, 0.03%- 4.6%) and pain at the biopsy site (2%; 95% CI, 0.04%-3.9%). No fatalities related to US-TTNAB were observed. Conclusion: US-TTNAB performed by respiratory physicians is a safe procedure with a low risk of complications and the diagnostic yield to establish a malignant diagnosis is acceptable.

KW - Lung cancer

KW - Pleura

KW - Pleural Neoplasms

KW - Ultrasound

KW - ultrasound guided transthoracic needle aspiration biopsy

KW - Diagnosis

KW - Multicenter study

KW - outpatient care

U2 - 10.1097/LBR.0000000000000297

DO - 10.1097/LBR.0000000000000297

M3 - Journal article

C2 - 27454475

VL - 23

SP - 220

EP - 228

JO - Journal of Bronchology & Interventional Pulmonology

JF - Journal of Bronchology & Interventional Pulmonology

SN - 1944-6586

IS - 3

ER -