Type of hematological malignancy is crucial for the return to work prognosis: a register-based cohort study

Trine Allerslev Horsboel*, Claus V. Nielsen, Bendt Nielsen, Chris Jensen, Niels Trolle Andersen, Annette de Thurah

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review


PURPOSE: The aims of this study were to determine the proportion of return to work (RTW) among sick-listed patients diagnosed with one of eight subtypes of hematological malignancies; to evaluate the influence of type of hematological malignancy, comorbidity, use of anxiolytics and antidepressants, socioeconomic and demographic factors on RTW; and to investigate if these associations differ between genders.

METHODS: We combined data from national registers on all Danish patients diagnosed with hematological malignancies between 2000 and 2007. A total of 1,741 patients on long-term sick leave were followed until RTW, emigration, permanent withdrawal from the labor market, death, or February 2012, whichever came first.

RESULTS: A total of 1,140 (65 %) patients returned to work. A strong association was found between type of diagnosis and RTW (p < 0.001), and the proportion of RTW was lowest for patients with multiple myeloma or acute leukemia compared to patients with Hodgkin lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, chronic myeloid leukemia, and chronic lymphoid leukemia. Use of antidepressants or anxiolytics after diagnosis, gender, age, and educational level were also associated with RTW. Surprisingly, comorbidity was not associated with RTW (p = 0.94); gender only modified the association between age and RTW.

CONCLUSION: Two thirds of patients with hematological malignancies on sick leave RTW. A number of factors seem to lead to a poor prognosis, the hematological diagnosis being the most important, and these should be taken into account when performing studies on work outcome for patients with hematological malignancies.

IMPLICATIONS FOR CANCER SURVIVORS: Knowledge in this area should assist in identification of hematological cancer patients at risk of not returning to work so that early targeted rehabilitation interventions can be initiated.

Original languageEnglish
JournalJournal of Cancer Survivorship
Issue number4
Pages (from-to)614-23
Publication statusPublished - Dec 2013
Externally publishedYes


  • Adult
  • Anti-Anxiety Agents/administration & dosage
  • Antidepressive Agents/administration & dosage
  • Cohort Studies
  • Comorbidity
  • Denmark/epidemiology
  • Female
  • Hematologic Neoplasms/classification
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • Registries/statistics & numerical data
  • Return to Work/statistics & numerical data
  • Young Adult


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