Twin study on transplacental-acquired antibodies and attention deficit/hyperactivity disorder - A pilot study

Niels Bilenberg, David Hougaard, Bent Norgaard-Pedersen, Claudia Maria Nordenbæk, Jørn Olsen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

OBJECTIVE: We hypothesize that maternal transplacentally acquired antibodies may cause Attention Deficit/Hyperactivity Disorder (ADHD) symptoms years after birth, and tested the hypothesis in twins discordant for ADHD symptoms. METHOD: In a pre-screened sample of 7793 same sex twin pair's (4-18years) questionnaire data on hyperactivity and inattention was collected. Blood samples taken 5days after birth from 190 ADHD-score discordant pairs (15% MZ) were analyzed for antibodies. RESULTS: Pneumococcus Polysaccaride 14 (PnPs14) was present in the ADHD high scoring twin more often than in the lower scoring twin (P=0.04). CONCLUSION: Although the study provides no strong support for the hypothesis, infection or immunological factors may be one among several causes of ADHD. The genetic control obtained in a twin design may reduce the exposure contrast and a larger sample is needed to further explore the role of PnPs14 in the etiology of ADHD.
Translated title of the contributionTvillingestudie af transplacentalt passerede antistoffer og ADHD: Pilotstudie
Original languageEnglish
JournalJournal of Neuroimmunology
Volume236
Pages (from-to)72-75
Number of pages4
ISSN0165-5728
DOIs
Publication statusPublished - 2011

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