Tumor-site specific geometric distortions in high field integrated magnetic resonance linear accelerator radiotherapy

Signe Winther Hasler; Uffe Bernchou; Anders Bertelsen; Elisabeth van Veldhuizen; Tine Schytte; Vibeke Nordmark Hansen; Carsten Brink; Faisal Mahmood

doi:10.1016/j.phro.2020.07.007

Tumor-site specific geometric distortions in high field integrated magnetic resonance linear accelerator radiotherapy

Signe Winther Hasler^*
, Uffe Bernchou
, Anders Bertelsen
, Elisabeth van Veldhuizen
, Tine Schytte
, Vibeke Nordmark Hansen
, Carsten Brink
, Faisal Mahmood

^*Corresponding author for this work

KI, OUH, Research unit of Oncology (Odense)

Odense University Hospital

Research output: Contribution to journal › Journal article › Research › peer-review

135 Downloads (Pure)

Abstract

Magnetic resonance imaging (MRI) has exquisite soft-tissue contrast and is the foundation for image guided radiotherapy (IGRT) with integrated magnetic resonance linacs. However, MRI suffers from geometrical distortions. In this study the MRI system- and patient-induced geometric distortion at four different tumor-sites was investigated: adrenal gland (7 patients), liver (4 patients), pancreas (6 patients), prostate (20 patients). Maximum level of total distortion within the gross-tumor-volume (GTV) was 0.96 mm with no significant difference between abdominal patients (adrenal gland, liver, pancreas) and pelvic patients (prostate). Total tumor-site specific distortion depended on location in the field-of-view and increased with the distance to MRI iso-center.

Original language	English
Journal	Physics and Imaging in Radiation Oncology
Volume	15
Pages (from-to)	100-104
ISSN	2405-6316
DOIs	https://doi.org/10.1016/j.phro.2020.07.007
Publication status	Published - Jul 2020

Funding

This work is supported by DCCC Radiotherapy - The Danish National Research Center for Radiotherapy, Danish Cancer Society (grant no. R191-A11526 ) and Danish Comprehensive Cancer Center , OUH & RH Research Fund (grant no. 58-A2857 ) and the Danish Cancer Society (grant no. R231-A13852 ). The funding sources have no other involvement than financial support.

Keywords

Adaptive radiotherapy
Geometric distortion
MR guided radiotherapy
MR-linac
MRI
QA

Documents & Links

10.1016/j.phro.2020.07.007Licence: CC BY-NC-ND

Open Access VersionFinal published version, 2.42 MBLicence: CC BY-NC-ND

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1 Ph.D. thesis

Investigating geometric distortions in MRI used for radiotherapy: A national study
Hasler, S. W., 7. Feb 2024, Syddansk Universitet. Det Sundhedsvidenskabelige Fakultet. 131 p.
Research output: Thesis › Ph.D. thesis

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Cite this

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title = "Tumor-site specific geometric distortions in high field integrated magnetic resonance linear accelerator radiotherapy",

abstract = "Magnetic resonance imaging (MRI) has exquisite soft-tissue contrast and is the foundation for image guided radiotherapy (IGRT) with integrated magnetic resonance linacs. However, MRI suffers from geometrical distortions. In this study the MRI system- and patient-induced geometric distortion at four different tumor-sites was investigated: adrenal gland (7 patients), liver (4 patients), pancreas (6 patients), prostate (20 patients). Maximum level of total distortion within the gross-tumor-volume (GTV) was 0.96 mm with no significant difference between abdominal patients (adrenal gland, liver, pancreas) and pelvic patients (prostate). Total tumor-site specific distortion depended on location in the field-of-view and increased with the distance to MRI iso-center.",

keywords = "Adaptive radiotherapy, Geometric distortion, MR guided radiotherapy, MR-linac, MRI, QA",

author = "Hasler, \{Signe Winther\} and Uffe Bernchou and Anders Bertelsen and \{van Veldhuizen\}, Elisabeth and Tine Schytte and Hansen, \{Vibeke Nordmark\} and Carsten Brink and Faisal Mahmood",

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doi = "10.1016/j.phro.2020.07.007",

language = "English",

volume = "15",

pages = "100--104",

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T1 - Tumor-site specific geometric distortions in high field integrated magnetic resonance linear accelerator radiotherapy

AU - Hasler, Signe Winther

AU - Bernchou, Uffe

AU - Bertelsen, Anders

AU - van Veldhuizen, Elisabeth

AU - Schytte, Tine

AU - Hansen, Vibeke Nordmark

AU - Brink, Carsten

AU - Mahmood, Faisal

PY - 2020/7

Y1 - 2020/7

N2 - Magnetic resonance imaging (MRI) has exquisite soft-tissue contrast and is the foundation for image guided radiotherapy (IGRT) with integrated magnetic resonance linacs. However, MRI suffers from geometrical distortions. In this study the MRI system- and patient-induced geometric distortion at four different tumor-sites was investigated: adrenal gland (7 patients), liver (4 patients), pancreas (6 patients), prostate (20 patients). Maximum level of total distortion within the gross-tumor-volume (GTV) was 0.96 mm with no significant difference between abdominal patients (adrenal gland, liver, pancreas) and pelvic patients (prostate). Total tumor-site specific distortion depended on location in the field-of-view and increased with the distance to MRI iso-center.

AB - Magnetic resonance imaging (MRI) has exquisite soft-tissue contrast and is the foundation for image guided radiotherapy (IGRT) with integrated magnetic resonance linacs. However, MRI suffers from geometrical distortions. In this study the MRI system- and patient-induced geometric distortion at four different tumor-sites was investigated: adrenal gland (7 patients), liver (4 patients), pancreas (6 patients), prostate (20 patients). Maximum level of total distortion within the gross-tumor-volume (GTV) was 0.96 mm with no significant difference between abdominal patients (adrenal gland, liver, pancreas) and pelvic patients (prostate). Total tumor-site specific distortion depended on location in the field-of-view and increased with the distance to MRI iso-center.

KW - Adaptive radiotherapy

KW - Geometric distortion

KW - MR guided radiotherapy

KW - MR-linac

KW - MRI

KW - QA

U2 - 10.1016/j.phro.2020.07.007

DO - 10.1016/j.phro.2020.07.007

M3 - Journal article

C2 - 33458333

AN - SCOPUS:85089497461

SN - 2405-6316

VL - 15

SP - 100

EP - 104

JO - Physics and Imaging in Radiation Oncology

JF - Physics and Imaging in Radiation Oncology

ER -

Tumor-site specific geometric distortions in high field integrated magnetic resonance linear accelerator radiotherapy

Abstract

Funding

Keywords

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Related research output

Investigating geometric distortions in MRI used for radiotherapy: A national study

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