TSH, thyroid hormones and nuclear-binding of T3 in mononuclear blood cells from obese and non-obese women

L E Matzen, J Kvetny, K K Pedersen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The specific nuclear-binding of T3 (NBT3) in mononuclear blood cells, and the concentrations of TSH, thyroid hormones, and binding proteins were measured after overnight fasting in 12 obese and in 14 non-obese women, none of the subjects were taking any medicine. The concentrations of TSH and free plus bound-T3 (TT3) were significantly higher in the obese (p less than 0.05), concentrations of T4 and binding proteins did not differ. The NBT3 was significantly lower in the obese women; the maximal binding capacity (MBC) was 34.5 +/- 11.6 fmol/mg DNA in the obese subjects and 50.0 +/- 11.6 fmol/mg DNA in the non-obese subjects (p less than 0.02). The binding affinities did not differ. We have previously shown that increasing T3 concentrations within the physiological range down-regulates NBT3. Therefore, the reduced NBT3 in the obese women was probably secondary to the increased TT3 concentration and was not caused by a primary tissue resistance. The higher TSH and TT3 in the obese women could be caused by a greater caloric intake.
Original languageEnglish
JournalScandinavian Journal of Clinical & Laboratory Investigation
Volume49
Issue number3
Pages (from-to)249-53
Number of pages4
ISSN0036-5513
Publication statusPublished - 1989

Keywords

  • Adult
  • Cell Nucleus
  • Female
  • Humans
  • Middle Aged
  • Monocytes
  • Obesity
  • Prealbumin
  • Receptors, Thyroid Hormone
  • Serum Albumin
  • Thyrotropin
  • Thyroxine-Binding Proteins

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