Trends in antidepressant use among children and adolescents

a Scandinavian drug utilization study

R Wesselhoeft, P B Jensen, A Talati, J Reutfors, K Furu, K Strandberg-Larsen, P Damkier, A Pottegård, M Bliddal

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

OBJECTIVE: To compare antidepressant utilization in individuals aged 5-19 years from the Scandinavian countries.

METHODS: A population-based drug utilization study using publicly available data of antidepressant use from Denmark, Norway, and Sweden.

RESULTS: In the study period from 2007 to 2017, the proportion of antidepressant users increased markedly in Sweden (9.3-18.0/1000) compared to Norway (5.1-7.6/1000) and Denmark (9.3-7.5/1000). In 2017, the cumulated defined daily doses (DDD) of selective serotonin reuptake inhibitors were 5611/1000 inhabitants in Sweden, 2709/1000 in Denmark, and 1848/1000 in Norway. The use of 'other antidepressants' (ATC code N06AX) also increased in Sweden with a higher DDD in 2017 (497/1000) compared to Denmark (225/1000) and Norway (170/1000). The use of tricyclic antidepressants was generally low in 2017 with DDDs ranging between 30-42 per 1000. The proportion of antidepressant users was highest among 15- to 19-year-old individuals. Girls were more likely to receive treatment than boys, and the treated female/male ratios per 1000 were similar in Sweden (2.39), Denmark (2.44), and Norway (2.63).

CONCLUSION: Even in highly comparable healthcare systems like the Scandinavian countries', variation in antidepressant use is considerable. Swedish children and adolescents have a markedly higher and still increasing use of antidepressants compared to Danish and Norwegian peers.

Original languageEnglish
JournalActa Psychiatrica Scandinavica
ISSN0001-690X
DOIs
Publication statusE-pub ahead of print - 16. Oct 2019

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Drug Utilization
Denmark
Norway
Dichlorodiphenyldichloroethane
Serotonin Uptake Inhibitors
Delivery of Health Care

Cite this

@article{383ccb9da9e54bc3a4f5c97f766d936b,
title = "Trends in antidepressant use among children and adolescents: a Scandinavian drug utilization study",
abstract = "OBJECTIVE: To compare antidepressant utilization in individuals aged 5-19 years from the Scandinavian countries.METHODS: A population-based drug utilization study using publicly available data of antidepressant use from Denmark, Norway, and Sweden.RESULTS: In the study period from 2007 to 2017, the proportion of antidepressant users increased markedly in Sweden (9.3-18.0/1000) compared to Norway (5.1-7.6/1000) and Denmark (9.3-7.5/1000). In 2017, the cumulated defined daily doses (DDD) of selective serotonin reuptake inhibitors were 5611/1000 inhabitants in Sweden, 2709/1000 in Denmark, and 1848/1000 in Norway. The use of 'other antidepressants' (ATC code N06AX) also increased in Sweden with a higher DDD in 2017 (497/1000) compared to Denmark (225/1000) and Norway (170/1000). The use of tricyclic antidepressants was generally low in 2017 with DDDs ranging between 30-42 per 1000. The proportion of antidepressant users was highest among 15- to 19-year-old individuals. Girls were more likely to receive treatment than boys, and the treated female/male ratios per 1000 were similar in Sweden (2.39), Denmark (2.44), and Norway (2.63).CONCLUSION: Even in highly comparable healthcare systems like the Scandinavian countries', variation in antidepressant use is considerable. Swedish children and adolescents have a markedly higher and still increasing use of antidepressants compared to Danish and Norwegian peers.",
author = "R Wesselhoeft and Jensen, {P B} and A Talati and J Reutfors and K Furu and K Strandberg-Larsen and P Damkier and A Potteg{\aa}rd and M Bliddal",
note = "{\circledC} 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",
year = "2019",
month = "10",
day = "16",
doi = "10.1111/acps.13116",
language = "English",
journal = "Acta Psychiatrica Scandinavica",
issn = "0001-690X",
publisher = "John Wiley & Sons Ltd",

}

Trends in antidepressant use among children and adolescents : a Scandinavian drug utilization study. / Wesselhoeft, R; Jensen, P B; Talati, A; Reutfors, J; Furu, K; Strandberg-Larsen, K; Damkier, P; Pottegård, A; Bliddal, M.

In: Acta Psychiatrica Scandinavica, 16.10.2019.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Trends in antidepressant use among children and adolescents

T2 - a Scandinavian drug utilization study

AU - Wesselhoeft, R

AU - Jensen, P B

AU - Talati, A

AU - Reutfors, J

AU - Furu, K

AU - Strandberg-Larsen, K

AU - Damkier, P

AU - Pottegård, A

AU - Bliddal, M

N1 - © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2019/10/16

Y1 - 2019/10/16

N2 - OBJECTIVE: To compare antidepressant utilization in individuals aged 5-19 years from the Scandinavian countries.METHODS: A population-based drug utilization study using publicly available data of antidepressant use from Denmark, Norway, and Sweden.RESULTS: In the study period from 2007 to 2017, the proportion of antidepressant users increased markedly in Sweden (9.3-18.0/1000) compared to Norway (5.1-7.6/1000) and Denmark (9.3-7.5/1000). In 2017, the cumulated defined daily doses (DDD) of selective serotonin reuptake inhibitors were 5611/1000 inhabitants in Sweden, 2709/1000 in Denmark, and 1848/1000 in Norway. The use of 'other antidepressants' (ATC code N06AX) also increased in Sweden with a higher DDD in 2017 (497/1000) compared to Denmark (225/1000) and Norway (170/1000). The use of tricyclic antidepressants was generally low in 2017 with DDDs ranging between 30-42 per 1000. The proportion of antidepressant users was highest among 15- to 19-year-old individuals. Girls were more likely to receive treatment than boys, and the treated female/male ratios per 1000 were similar in Sweden (2.39), Denmark (2.44), and Norway (2.63).CONCLUSION: Even in highly comparable healthcare systems like the Scandinavian countries', variation in antidepressant use is considerable. Swedish children and adolescents have a markedly higher and still increasing use of antidepressants compared to Danish and Norwegian peers.

AB - OBJECTIVE: To compare antidepressant utilization in individuals aged 5-19 years from the Scandinavian countries.METHODS: A population-based drug utilization study using publicly available data of antidepressant use from Denmark, Norway, and Sweden.RESULTS: In the study period from 2007 to 2017, the proportion of antidepressant users increased markedly in Sweden (9.3-18.0/1000) compared to Norway (5.1-7.6/1000) and Denmark (9.3-7.5/1000). In 2017, the cumulated defined daily doses (DDD) of selective serotonin reuptake inhibitors were 5611/1000 inhabitants in Sweden, 2709/1000 in Denmark, and 1848/1000 in Norway. The use of 'other antidepressants' (ATC code N06AX) also increased in Sweden with a higher DDD in 2017 (497/1000) compared to Denmark (225/1000) and Norway (170/1000). The use of tricyclic antidepressants was generally low in 2017 with DDDs ranging between 30-42 per 1000. The proportion of antidepressant users was highest among 15- to 19-year-old individuals. Girls were more likely to receive treatment than boys, and the treated female/male ratios per 1000 were similar in Sweden (2.39), Denmark (2.44), and Norway (2.63).CONCLUSION: Even in highly comparable healthcare systems like the Scandinavian countries', variation in antidepressant use is considerable. Swedish children and adolescents have a markedly higher and still increasing use of antidepressants compared to Danish and Norwegian peers.

U2 - 10.1111/acps.13116

DO - 10.1111/acps.13116

M3 - Journal article

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

SN - 0001-690X

ER -