Trained innate immunity as underlying mechanism for the long-term, nonspecific effects of vaccines

Bastiaan A Blok, Rob J W Arts, Reinout van Crevel, Christine Stabell Benn, Mihai G Netea

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

An increasing body of evidence shows that the innate immune system has adaptive characteristics that involve a heterologous memory of past insults. Both experimental models and proof-of-principle clinical trials show that innate immune cells, such as monocytes, macrophages, and NK cells, can provide protection against certain infections in vaccination models independently of lymphocytes. This process is regulated through epigenetic reprogramming of innate immune cells and has been termed "trained immunity." It has been hypothesized that induction of trained immunity is responsible for the protective, nonspecific effects induced by vaccines, such as BCG, measles vaccination, and other whole-microorganism vaccines. In this review, we will present the mechanisms of trained immunity responsible for the long-lasting effects of vaccines on the innate immune system.

Original languageEnglish
JournalJournal of Leukocyte Biology
Volume98
Issue number3
Pages (from-to)347-56
Number of pages10
ISSN0741-5400
DOIs
Publication statusPublished - Sep 2015

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Immune System
Measles
Mycobacterium bovis
Epigenomics
Theoretical Models
Macrophages
Clinical Trials

Keywords

  • Animals
  • Humans
  • Immunity, Innate
  • Immunologic Memory
  • Vaccines

Cite this

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Trained innate immunity as underlying mechanism for the long-term, nonspecific effects of vaccines. / Blok, Bastiaan A; Arts, Rob J W; van Crevel, Reinout; Benn, Christine Stabell; Netea, Mihai G.

In: Journal of Leukocyte Biology, Vol. 98, No. 3, 09.2015, p. 347-56.

Research output: Contribution to journalJournal articleResearchpeer-review

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