Toxicologic evidence of developmental neurotoxicity of environmental chemicals

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Abstract

Developmental neurotoxicity constitutes effects occurring in the offspring primarily as a result of exposure of the mother during pregnancy and lactation. To exert their effect, these chemicals or their metabolites must pass the placenta and/or the blood-brain barrier. In experimental animals, exposure to neurotoxic chemicals during critical periods of brain development has induced permanent functional disturbances in the CNS. Although available data suggest that proper animal models exist, only few chemicals have been tested. Neurotoxicity testing is not required by national authorities for classification of chemicals. Epidemiological evidence is very limited, but severe irreversible effects have been observed in humans following in utero exposures to a few known developmental neurotoxicants. The large number of chemicals with a potential for developmental neurotoxicity in humans stresses the importance of generating basic kinetic data on these chemicals based on relevant experimental models. First of all, data are needed on their ability to pass the placenta and the developing blood-brain barrier, to accumulate, and to be metabolized in the placenta and/or the fetus. These kinetic data will be essential in establishing a scientifically based hazard evaluation and risk assessment.

Original languageEnglish
JournalToxicology
Volume144
Issue number1-3
Pages (from-to)121-7
Number of pages7
ISSN0300-483X
Publication statusPublished - 2000

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Placenta
Animals
Fetus
Theoretical Models
Kinetics
Metabolites
Risk assessment
Brain
Hazards
Testing
Blood-Brain Barrier

Keywords

  • Animals
  • Environmental Pollutants
  • Female
  • Humans
  • Nervous System
  • Nervous System Diseases
  • Neurotoxins
  • Pregnancy
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review

Cite this

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title = "Toxicologic evidence of developmental neurotoxicity of environmental chemicals",
abstract = "Developmental neurotoxicity constitutes effects occurring in the offspring primarily as a result of exposure of the mother during pregnancy and lactation. To exert their effect, these chemicals or their metabolites must pass the placenta and/or the blood-brain barrier. In experimental animals, exposure to neurotoxic chemicals during critical periods of brain development has induced permanent functional disturbances in the CNS. Although available data suggest that proper animal models exist, only few chemicals have been tested. Neurotoxicity testing is not required by national authorities for classification of chemicals. Epidemiological evidence is very limited, but severe irreversible effects have been observed in humans following in utero exposures to a few known developmental neurotoxicants. The large number of chemicals with a potential for developmental neurotoxicity in humans stresses the importance of generating basic kinetic data on these chemicals based on relevant experimental models. First of all, data are needed on their ability to pass the placenta and the developing blood-brain barrier, to accumulate, and to be metabolized in the placenta and/or the fetus. These kinetic data will be essential in establishing a scientifically based hazard evaluation and risk assessment.",
keywords = "Animals, Environmental Pollutants, Female, Humans, Nervous System, Nervous System Diseases, Neurotoxins, Pregnancy, Journal Article, Research Support, Non-U.S. Gov't, Review",
author = "Andersen, {H R} and Nielsen, {J B} and P Grandjean",
year = "2000",
language = "English",
volume = "144",
pages = "121--7",
journal = "Toxicology",
issn = "0300-483X",
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number = "1-3",

}

Toxicologic evidence of developmental neurotoxicity of environmental chemicals. / Andersen, H R; Nielsen, J B; Grandjean, P.

In: Toxicology, Vol. 144, No. 1-3, 2000, p. 121-7.

Research output: Contribution to journalReviewResearchpeer-review

TY - JOUR

T1 - Toxicologic evidence of developmental neurotoxicity of environmental chemicals

AU - Andersen, H R

AU - Nielsen, J B

AU - Grandjean, P

PY - 2000

Y1 - 2000

N2 - Developmental neurotoxicity constitutes effects occurring in the offspring primarily as a result of exposure of the mother during pregnancy and lactation. To exert their effect, these chemicals or their metabolites must pass the placenta and/or the blood-brain barrier. In experimental animals, exposure to neurotoxic chemicals during critical periods of brain development has induced permanent functional disturbances in the CNS. Although available data suggest that proper animal models exist, only few chemicals have been tested. Neurotoxicity testing is not required by national authorities for classification of chemicals. Epidemiological evidence is very limited, but severe irreversible effects have been observed in humans following in utero exposures to a few known developmental neurotoxicants. The large number of chemicals with a potential for developmental neurotoxicity in humans stresses the importance of generating basic kinetic data on these chemicals based on relevant experimental models. First of all, data are needed on their ability to pass the placenta and the developing blood-brain barrier, to accumulate, and to be metabolized in the placenta and/or the fetus. These kinetic data will be essential in establishing a scientifically based hazard evaluation and risk assessment.

AB - Developmental neurotoxicity constitutes effects occurring in the offspring primarily as a result of exposure of the mother during pregnancy and lactation. To exert their effect, these chemicals or their metabolites must pass the placenta and/or the blood-brain barrier. In experimental animals, exposure to neurotoxic chemicals during critical periods of brain development has induced permanent functional disturbances in the CNS. Although available data suggest that proper animal models exist, only few chemicals have been tested. Neurotoxicity testing is not required by national authorities for classification of chemicals. Epidemiological evidence is very limited, but severe irreversible effects have been observed in humans following in utero exposures to a few known developmental neurotoxicants. The large number of chemicals with a potential for developmental neurotoxicity in humans stresses the importance of generating basic kinetic data on these chemicals based on relevant experimental models. First of all, data are needed on their ability to pass the placenta and the developing blood-brain barrier, to accumulate, and to be metabolized in the placenta and/or the fetus. These kinetic data will be essential in establishing a scientifically based hazard evaluation and risk assessment.

KW - Animals

KW - Environmental Pollutants

KW - Female

KW - Humans

KW - Nervous System

KW - Nervous System Diseases

KW - Neurotoxins

KW - Pregnancy

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

M3 - Review

VL - 144

SP - 121

EP - 127

JO - Toxicology

JF - Toxicology

SN - 0300-483X

IS - 1-3

ER -