Abstract
In DNA-templated synthesis, reactants are attached to DNA strands and complementary DNA strands are used to control the reaction towards a goal compound. This very general, simple, and still efficient approach has proven to be successful for the design of complex one-pot synthesis for a large
variety of compounds. For a given goal compound many different synthesis plans may exist, and all of them can potentially be implemented with many different DNA-templated programs. This raises the issue of how to automatically infer optimal low-level programs based on a high-level synthesis plan or a goal compound only. In this paper we will introduce a computational approach for DNA-templated synthesis based on graph rewriting approaches and the systematic exploration of chemical spaces. We will use them for verification of correctness of real-world synthesis plans as well as to illustrate the non-triviality of finding an optimal DNA assembler program.
variety of compounds. For a given goal compound many different synthesis plans may exist, and all of them can potentially be implemented with many different DNA-templated programs. This raises the issue of how to automatically infer optimal low-level programs based on a high-level synthesis plan or a goal compound only. In this paper we will introduce a computational approach for DNA-templated synthesis based on graph rewriting approaches and the systematic exploration of chemical spaces. We will use them for verification of correctness of real-world synthesis plans as well as to illustrate the non-triviality of finding an optimal DNA assembler program.
| Original language | English |
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| Title of host publication | Artificial Life 14 : Proceedings of the Fourteenth Conference on the Synthesis and Simulation of Living Systems |
| Editors | Hiroki Sayama, John Rieffel, Sebastian Risi, René Doursat, Hod Lipson |
| Publisher | MIT Press |
| Publication date | 30. Jul 2014 |
| Pages | 557-564 |
| ISBN (Electronic) | 9780262326216 |
| DOIs | |
| Publication status | Published - 30. Jul 2014 |
| Event | ALife 14: 14th International Conference on the Synthesis and Simulation of Living Systems - New York, United States Duration: 23. Jul 2014 → 26. Jul 2014 |
Conference
| Conference | ALife 14 |
|---|---|
| Country/Territory | United States |
| City | New York |
| Period | 23/07/2014 → 26/07/2014 |