Thyroidectomy improves quality of life in patients with euthyroid nodular goiter – a prospective cohort study

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Background: Using the thoroughly validated ThyPRO-questionnaire, we aimed at investigating changes in disease-specific quality of life (QoL), associated with surgical treatment in patients with euthyroid multinodular goiter. Method: Patients with euthyroid goiter scheduled for thyroid surgery were compared to a historic group from the general population (n=739). ThyPRO data before, three, and six months after surgery were compared with normative scores from the general population using a linear mixed model and non-paired t-tests. The effect size (ES) was estimated as mean change by standard deviation at baseline with ES of 0.2-0.5 defined as small, values of 0.5-0.8 as moderate, and scores >0.8 as large.Results: 106 patients, mean age 51 years (range 20-80); females: n=91, males: n=15; lobectomy: 78, total thyroidectomy: 22, isthmectomy: 6, were consecutively enrolled from November 2014 through April 2016. Before surgery, patients with goiter experienced poorer scores on all scales compared to the general population. After surgery, moderate to large improvements were seen in Goiter Symptoms (ES: 1.52), Tiredness (ES: 0.60), Anxiety (ES: 0.54), and Overall QoL (ES: 0.74). The remaining scales either experienced no change or small changes (ES:0.00-0.50). Post-surgery, with exception a reduced level of Anxiety, all scales returned to values similar to the general population.Conclusion: Thyroid surgery leads to significant benefit among patients with euthyroid goiter, and restores QoL to that in the reference population.
Original languageDanish
Publication date27. Jan 2017
Publication statusPublished - 27. Jan 2017
EventDansk Endokrinologisk Selskabs Årsmøde 2017 - Musikhuset, Esbjerg, Denmark
Duration: 27. Jan 201628. Jan 2017


ConferenceDansk Endokrinologisk Selskabs Årsmøde 2017

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