TY - JOUR
T1 - Thyroid hormones for euthyroid patients with simple goiter growing over time
T2 - a survey of European thyroid specialists
AU - Papini, Enrico
AU - Attanasio, Roberto
AU - Žarković, Miloš
AU - Nagy, Endre Vezekenyi
AU - Negro, Roberto
AU - Perros, Petros
AU - Galofré, Juan Carlos
AU - Cohen, Chagit Adler
AU - Akarsu, Ersin
AU - Alevizaki, Maria
AU - Ayvaz, Göksun
AU - Bednarczuk, Tomasz
AU - Beleslin, Biljana Nedeljković
AU - Berta, Eszter
AU - Bodor, Miklos
AU - Borissova, Anna Maria
AU - Boyanov, Mihail
AU - Buffet, Camille
AU - Burlacu, Maria Cristina
AU - Ćirić, Jasmina
AU - Díez, Juan J.
AU - Dobnig, Harald
AU - Fadeyev, Valentin
AU - Field, Benjamin C.T.
AU - Führer-Sakel, Dagmar
AU - Hakala, Tommi
AU - Jiskra, Jan
AU - Kopp, Peter Andreas
AU - Krebs, Michael
AU - Kršek, Michal
AU - Lantz, Mikael
AU - Lazúrová, Ivica
AU - Leenhardt, Laurence
AU - Luchytskiy, Vitaliy
AU - Puga, Francisca Marques
AU - McGowan, Anne
AU - Melo, Miguel
AU - Metso, Saara
AU - Moran, Carla
AU - Morgunova, Tatyana
AU - Niculescu, Dan Alexandru
AU - Perić, Božidar
AU - Planck, Tereza
AU - Robenshtok, Eyal
AU - Rosselet, Patrick Olivier
AU - Ruchala, Marek
AU - Riis, Kamilla Ryom
AU - Shepelkevich, Alla
AU - Tronko, Mykola
AU - Unuane, David
AU - Vardarli, Irfan
AU - Visser, W. Edward
AU - Vryonidou, Andromachi
AU - Younes, Younes Ramazan
AU - Hegedüs, Laszlo
PY - 2024
Y1 - 2024
N2 - Background: Treatment of simple goiter (SG) growing over time with thyroid hormone (TH) therapy is discouraged by international guidelines. Purpose: To ascertain views of European thyroid specialists about TH treatment for euthyroid patients with growing SG and explore associations with management choice. Methods: Online survey on the use of TH for growing SG among thyroid experts from 28 European countries. Results: The response rate was 31.5% (5430/17,247). Most respondents were endocrinologists. Twenty-eight percent asserted that TH therapy may be indicated in euthyroid patients with a growing SG. National and regional differences were noted, from 7% of positive responses in The Netherlands to 78% in Czech Republic (p < 0.0001). TH was more frequently prescribed by respondents over 40 years old (OR 1.77, 2.13, 2.41 if 41–50, 51–60, >60, respectively), and working in areas of former iodine insufficiency (OR 1.24, 95% CI 1.03–1.50). TH was less frequently prescribed by endocrinologists (OR 0.77, 95% CI 0.62-0.94) and respondents working in Southern Europe (OR 0.40, 95% CI 0.33–0.48), Northern Europe (OR 0.28, 95% CI 0.22–0.36) and Western Asia (OR 0.16, 95% CI 0.11–0.24) compared to Western Europe. Associations with respondents’ sex, country, availability of national thyroid guidelines, and gross national income per capita were absent or weak. Conclusions: Almost a third of European thyroid specialists support treating SG with TH, contrary to current guidelines and recommendations. This calls for urgent attention.
AB - Background: Treatment of simple goiter (SG) growing over time with thyroid hormone (TH) therapy is discouraged by international guidelines. Purpose: To ascertain views of European thyroid specialists about TH treatment for euthyroid patients with growing SG and explore associations with management choice. Methods: Online survey on the use of TH for growing SG among thyroid experts from 28 European countries. Results: The response rate was 31.5% (5430/17,247). Most respondents were endocrinologists. Twenty-eight percent asserted that TH therapy may be indicated in euthyroid patients with a growing SG. National and regional differences were noted, from 7% of positive responses in The Netherlands to 78% in Czech Republic (p < 0.0001). TH was more frequently prescribed by respondents over 40 years old (OR 1.77, 2.13, 2.41 if 41–50, 51–60, >60, respectively), and working in areas of former iodine insufficiency (OR 1.24, 95% CI 1.03–1.50). TH was less frequently prescribed by endocrinologists (OR 0.77, 95% CI 0.62-0.94) and respondents working in Southern Europe (OR 0.40, 95% CI 0.33–0.48), Northern Europe (OR 0.28, 95% CI 0.22–0.36) and Western Asia (OR 0.16, 95% CI 0.11–0.24) compared to Western Europe. Associations with respondents’ sex, country, availability of national thyroid guidelines, and gross national income per capita were absent or weak. Conclusions: Almost a third of European thyroid specialists support treating SG with TH, contrary to current guidelines and recommendations. This calls for urgent attention.
KW - Goiter
KW - Levothyroxine
KW - Survey
KW - Thyroid hormone
KW - TSH-suppressive therapy
U2 - 10.1007/s12020-024-04002-z
DO - 10.1007/s12020-024-04002-z
M3 - Journal article
C2 - 39217207
AN - SCOPUS:85202766336
SN - 1355-008X
JO - Endocrine
JF - Endocrine
ER -