Therapeutisches Drug-Monitoring in der Neuropsychopharmakologie: Zusammenfassung der Konsensusleitlinien 2017 der TDM-Arbeitsgruppe der AGNP

Stefan Unterecker; Gudrun Hefner; Pierre Baumann; Gerd Gründer; Niels Bergemann; Hans Willi Clement; Andreas Conca; Jürgen Deckert; Katharina Domschke; Gabriel Eckermann; Karin Egberts; Manfred Gerlach; Christine Greiner; Ekkehard Haen; Ursula Havemann-Reinecke; Renate Helmer; Ger Janssen; Eveline Jaquenoud; Gerd Laux; Thomas Messer; Rainald Mössner; Matthias J. Müller; Michael Paulzen; Bruno Pfuhlmann; Peter Riederer; Alois Saria; Bernd Schoppek; Georgios Schoretsanitis; Markus Schwarz; Margarethe Silva Gracia; Benedikt Stegmann; Werner Steimer; Julia C. Stingl; Manfred Uhr; Sven Ulrich; Roland Waschgler; Gerald Zernig; Gabriele Zurek; Christoph Hiemke

doi:10.1007/s00115-018-0643-9

Therapeutisches Drug-Monitoring in der Neuropsychopharmakologie: Zusammenfassung der Konsensusleitlinien 2017 der TDM-Arbeitsgruppe der AGNP

Translated title of the contribution: Therapeutic drug monitoring in neuropsychopharmacology: Summary of the consensus guidelines 2017 of the TDM task force of the AGNP

Stefan Unterecker^*, Gudrun Hefner, Pierre Baumann, Gerd Gründer, Niels Bergemann, Hans Willi Clement, Andreas Conca, Jürgen Deckert, Katharina Domschke, Gabriel Eckermann, Karin Egberts, Manfred Gerlach, Christine Greiner, Ekkehard Haen, Ursula Havemann-Reinecke, Renate Helmer, Ger Janssen, Eveline Jaquenoud, Gerd Laux, Thomas MesserRainald Mössner, Matthias J. Müller, Michael Paulzen, Bruno Pfuhlmann, Peter Riederer, Alois Saria, Bernd Schoppek, Georgios Schoretsanitis, Markus Schwarz, Margarethe Silva Gracia, Benedikt Stegmann, Werner Steimer, Julia C. Stingl, Manfred Uhr, Sven Ulrich, Roland Waschgler, Gerald Zernig, Gabriele Zurek, Christoph Hiemke

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug concentrations in blood serum or plasma to optimize pharmacological therapy. TDM is an instrument with which the high interindividual variability of pharmacokinetics of patients can be identified and therefore enables a personalized pharmacotherapy. In September 2017 the TDM task force of the Working Group for Neuropsychopharmacology and Pharmacopsychiatry (AGNP) published an update of the consensus guidelines on TDM published in 2011. This article summarizes the essential statements for the clinical practice in psychiatry and neurology.

Translated title of the contribution	Therapeutic drug monitoring in neuropsychopharmacology: Summary of the consensus guidelines 2017 of the TDM task force of the AGNP
Original language	German
Journal	Der Nervenarzt
Volume	90
Issue number	5
Pages (from-to)	463-471
ISSN	0028-2804
DOIs	https://doi.org/10.1007/s00115-018-0643-9
Publication status	Published - 1. May 2019
Externally published	Yes

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10.1007/s00115-018-0643-9

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Unterecker, S., Hefner, G., Baumann, P., Gründer, G., Bergemann, N., Clement, H. W., Conca, A., Deckert, J., Domschke, K., Eckermann, G., Egberts, K., Gerlach, M., Greiner, C., Haen, E., Havemann-Reinecke, U., Helmer, R., Janssen, G., Jaquenoud, E., Laux, G., ... Hiemke, C. (2019). Therapeutisches Drug-Monitoring in der Neuropsychopharmakologie: Zusammenfassung der Konsensusleitlinien 2017 der TDM-Arbeitsgruppe der AGNP. Der Nervenarzt, 90(5), 463-471. https://doi.org/10.1007/s00115-018-0643-9

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title = "Therapeutisches Drug-Monitoring in der Neuropsychopharmakologie: Zusammenfassung der Konsensusleitlinien 2017 der TDM-Arbeitsgruppe der AGNP",

abstract = "Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug concentrations in blood serum or plasma to optimize pharmacological therapy. TDM is an instrument with which the high interindividual variability of pharmacokinetics of patients can be identified and therefore enables a personalized pharmacotherapy. In September 2017 the TDM task force of the Working Group for Neuropsychopharmacology and Pharmacopsychiatry (AGNP) published an update of the consensus guidelines on TDM published in 2011. This article summarizes the essential statements for the clinical practice in psychiatry and neurology.",

keywords = "Dose-related reference range, Drug concentration, Neuropsychotropic drugs, Psychopharmacotherapy, Therapeutic reference range, Guidelines as Topic, Humans, Psychopharmacology, Neuropharmacology, Psychotropic Drugs/therapeutic use, Drug Monitoring",

author = "Stefan Unterecker and Gudrun Hefner and Pierre Baumann and Gerd Gr{\"u}nder and Niels Bergemann and Clement, {Hans Willi} and Andreas Conca and J{\"u}rgen Deckert and Katharina Domschke and Gabriel Eckermann and Karin Egberts and Manfred Gerlach and Christine Greiner and Ekkehard Haen and Ursula Havemann-Reinecke and Renate Helmer and Ger Janssen and Eveline Jaquenoud and Gerd Laux and Thomas Messer and Rainald M{\"o}ssner and M{\"u}ller, {Matthias J.} and Michael Paulzen and Bruno Pfuhlmann and Peter Riederer and Alois Saria and Bernd Schoppek and Georgios Schoretsanitis and Markus Schwarz and Gracia, {Margarethe Silva} and Benedikt Stegmann and Werner Steimer and Stingl, {Julia C.} and Manfred Uhr and Sven Ulrich and Roland Waschgler and Gerald Zernig and Gabriele Zurek and Christoph Hiemke",

year = "2019",

month = may,

day = "1",

doi = "10.1007/s00115-018-0643-9",

language = "Tysk",

volume = "90",

pages = "463--471",

journal = "Der Nervenarzt",

issn = "0028-2804",

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Unterecker, S, Hefner, G, Baumann, P, Gründer, G, Bergemann, N, Clement, HW, Conca, A, Deckert, J, Domschke, K, Eckermann, G, Egberts, K, Gerlach, M, Greiner, C, Haen, E, Havemann-Reinecke, U, Helmer, R, Janssen, G, Jaquenoud, E, Laux, G, Messer, T, Mössner, R, Müller, MJ, Paulzen, M, Pfuhlmann, B, Riederer, P, Saria, A, Schoppek, B, Schoretsanitis, G, Schwarz, M, Gracia, MS, Stegmann, B, Steimer, W, Stingl, JC, Uhr, M, Ulrich, S, Waschgler, R, Zernig, G, Zurek, G & Hiemke, C 2019, 'Therapeutisches Drug-Monitoring in der Neuropsychopharmakologie: Zusammenfassung der Konsensusleitlinien 2017 der TDM-Arbeitsgruppe der AGNP', Der Nervenarzt, vol. 90, no. 5, pp. 463-471. https://doi.org/10.1007/s00115-018-0643-9

TY - JOUR

T1 - Therapeutisches Drug-Monitoring in der Neuropsychopharmakologie

T2 - Zusammenfassung der Konsensusleitlinien 2017 der TDM-Arbeitsgruppe der AGNP

AU - Unterecker, Stefan

AU - Hefner, Gudrun

AU - Baumann, Pierre

AU - Gründer, Gerd

AU - Bergemann, Niels

AU - Clement, Hans Willi

AU - Conca, Andreas

AU - Deckert, Jürgen

AU - Domschke, Katharina

AU - Eckermann, Gabriel

AU - Egberts, Karin

AU - Gerlach, Manfred

AU - Greiner, Christine

AU - Haen, Ekkehard

AU - Havemann-Reinecke, Ursula

AU - Helmer, Renate

AU - Janssen, Ger

AU - Jaquenoud, Eveline

AU - Laux, Gerd

AU - Messer, Thomas

AU - Mössner, Rainald

AU - Müller, Matthias J.

AU - Paulzen, Michael

AU - Pfuhlmann, Bruno

AU - Riederer, Peter

AU - Saria, Alois

AU - Schoppek, Bernd

AU - Schoretsanitis, Georgios

AU - Schwarz, Markus

AU - Gracia, Margarethe Silva

AU - Stegmann, Benedikt

AU - Steimer, Werner

AU - Stingl, Julia C.

AU - Uhr, Manfred

AU - Ulrich, Sven

AU - Waschgler, Roland

AU - Zernig, Gerald

AU - Zurek, Gabriele

AU - Hiemke, Christoph

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug concentrations in blood serum or plasma to optimize pharmacological therapy. TDM is an instrument with which the high interindividual variability of pharmacokinetics of patients can be identified and therefore enables a personalized pharmacotherapy. In September 2017 the TDM task force of the Working Group for Neuropsychopharmacology and Pharmacopsychiatry (AGNP) published an update of the consensus guidelines on TDM published in 2011. This article summarizes the essential statements for the clinical practice in psychiatry and neurology.

AB - Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug concentrations in blood serum or plasma to optimize pharmacological therapy. TDM is an instrument with which the high interindividual variability of pharmacokinetics of patients can be identified and therefore enables a personalized pharmacotherapy. In September 2017 the TDM task force of the Working Group for Neuropsychopharmacology and Pharmacopsychiatry (AGNP) published an update of the consensus guidelines on TDM published in 2011. This article summarizes the essential statements for the clinical practice in psychiatry and neurology.

KW - Dose-related reference range

KW - Drug concentration

KW - Neuropsychotropic drugs

KW - Psychopharmacotherapy

KW - Therapeutic reference range

KW - Guidelines as Topic

KW - Humans

KW - Psychopharmacology

KW - Neuropharmacology

KW - Psychotropic Drugs/therapeutic use

KW - Drug Monitoring

U2 - 10.1007/s00115-018-0643-9

DO - 10.1007/s00115-018-0643-9

M3 - Tidsskriftartikel

C2 - 30446893

AN - SCOPUS:85056702799

SN - 0028-2804

VL - 90

SP - 463

EP - 471

JO - Der Nervenarzt

JF - Der Nervenarzt

IS - 5

ER -

Therapeutisches Drug-Monitoring in der Neuropsychopharmakologie: Zusammenfassung der Konsensusleitlinien 2017 der TDM-Arbeitsgruppe der AGNP

Abstract

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