The variability of ST segment in the early phase of acute myocardial infarction

K. Thygesen, M. Horder, B. L. Nielsen, P. H. Petersen

    Research output: Contribution to journalJournal articleResearchpeer-review


    The ST segment elevation was measured hourly, via a single surface unipolar lead for 48 hours after admission, in 30 patients with acute myocardial infarction (AMI), admitted, on average, 2 hour after the onset of symptoms. In 14 patients with anterior AMI, the recordings were made through the precordial lead that initially showed the maximum ST elevation. In 16 patients with inferior AMI, the a VF lead was used. Twenty-five control patients without AMI had the ST deviation measured hourly for 24 hours; 15 of them had the recording made via the V3, aVF being used with the others. Authors' data for the reliability of the method showed that the variations in ST deviations in the control group were of the same magnitude as those observed with the measruing error of the method itself. The investigation showed that the spontaneous course of the hourly measured ST elevations in the early phase of AMI was marked by pronounced variability, and that this applied to both anterior and inferior infarctions. The intra-individual patient variation of the ST elevation was significantly greater than in the control group of patients. The inter-individual patient variation of the ST elevation with AMI was also significant. The ST elevation was correlated to heart rate, mean arterial blood pressure, heart rate multiplied by systolic blood pressure, and respiratory rate and it could be shown partly that there was a significant dispersion of the correlation coefficients within the separate correlation groups, and partly that the correlation coefficients were variable between the groups. It was also shown that nasal oxygen therapy and cardiac pain had no bearing on ST elevation. The variability of ST elevation was thus most often inexplicable and only rarely accounted for by alterations in the clinical status.

    Original languageEnglish
    Issue numberSUPPL. 623
    Pages (from-to)61-70
    Publication statusPublished - 1. Jan 1978


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