The Validity of Intracerebral Hemorrhage Diagnoses in the Danish Patient Registry and the Danish Stroke Registry

Stine Munk Hald, Christine Kring Sloth, Mikkel Agger, Maria Therese Schelde-Olesen, Miriam Højholt, Mette Hasle, Helle Bogetofte, Ida Olesrud, Stefanie Binzer, Charlotte Madsen, Willy Krone, Luis Alberto García Rodríguez, Rustam Al Shahi Salman, Jesper Hallas, David Gaist*

*Corresponding author for this work

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Purpose: To establish the validity of intracerebral hemorrhage (ICH) diagnoses in the Danish Stroke Registry (DSR) and the Danish National Patient Registry (DNPR). Patients and Methods: Based on discharge summaries and brain imaging reports, we estimated the positive predictive value (PPV) of a first-ever diagnosis code for ICH (ICD-10, code I61) for all patients in the Region of Southern Denmark (1.2 million) during 2009–2017 according to either DNPR or DSR. We estimated PPVs for any non-traumatic ICH (a-ICH) and spontaneous ICH (s-ICH) alone (ie, without underlying structural cause). We also calculated the sensitivity of these diagnoses in each of the registers. Finally, we classified the location of verified s-ICH. Results: A total of 3,956 patients with ICH diagnosis codes were studied (DSR only: 87; DNPR only: 1,513; both registries: 2,356). In the DSR, the PPVs were 86.5% (95% CI=85.1– 87.8) for a-ICH and 81.8% (95% CI=80.2–83.3) for s-ICH. The PPVs in DNPR (discharge code, primary diagnostic position) were 76.2% (95% CI=74.7–77.6) for a-ICH and 70.2% (95% CI=68.6–71.8) for s-ICH. Sensitivity for a-ICH and s-ICH was 76.4% (95% CI=74.8– 78.0) and 78.7% (95% CI=77.1–80.2) in DSR, and 87.3% (95% CI=86.0–88.5) and 87.7% (95% CI=86.3–88.9) in DNPR. The location of verified s-ICH was lobar (39%), deep (33.6%), infratentorial (13.2%), large unclassifiable (11%), isolated intraventricular (1.9%), or unclas-sifiable due to insufficient information (1.3%). Conclusion: The validity of a-ICH diagnoses is high in both registries. For s-ICH, PPV was higher in DSR, while sensitivity was higher in DNPR. The location of s-ICH was similar to distributions seen in other populations.

Original languageEnglish
JournalClinical Epidemiology
Pages (from-to)1313-1325
Publication statusPublished - 1. Dec 2020


  • Epidemiology
  • Intracerebral hemorrhage
  • Register-based research
  • Stroke
  • Validity


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