The use of mesenchymal (skeletal) stem cells for treatment of degenerative diseases: current status and future perspectives

Basem Abdallah, Moustapha Kassem

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Human bone marrow derived-mesenchymal (skeletal) stem (MSC) cells are a group of non-hematopoietic stem cells residing in the perivascular niches in bone marrow. These cells have the capacity to differentiate mainly into mesoderm-type cells such as osteoblasts, chondrocytes and adipocytes and possibly but not proven to non-mesodermal cell types. Recently, there has been an increased interest in understanding the biology of MSC due to their potential use in cell-based therapy for multiple degenerative diseases. Here, we will provide an update on the current status of these novel therapeutic opportunities. J. Cell. Physiol. 218: 9-12, 2009. (c) 2008 Wiley-Liss, Inc.
Original languageEnglish
JournalJournal of Cellular Physiology
Volume218
Issue number1
Pages (from-to)9-12
Number of pages3
ISSN0021-9541
DOIs
Publication statusPublished - 1. Jan 2009

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Mesenchymal Stromal Cells
Mesoderm
Chondrocytes
Osteoblasts
Adipocytes

Keywords

  • Animals
  • Bone Diseases
  • Bone Regeneration
  • Cardiovascular Diseases
  • Cell Separation
  • Graft vs Host Disease
  • Hematopoiesis
  • Humans
  • Mesenchymal Stem Cell Transplantation
  • Mesenchymal Stem Cells
  • Multipotent Stem Cells
  • Stromal Cells
  • Tissue Engineering

Cite this

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title = "The use of mesenchymal (skeletal) stem cells for treatment of degenerative diseases: current status and future perspectives",
abstract = "Human bone marrow derived-mesenchymal (skeletal) stem (MSC) cells are a group of non-hematopoietic stem cells residing in the perivascular niches in bone marrow. These cells have the capacity to differentiate mainly into mesoderm-type cells such as osteoblasts, chondrocytes and adipocytes and possibly but not proven to non-mesodermal cell types. Recently, there has been an increased interest in understanding the biology of MSC due to their potential use in cell-based therapy for multiple degenerative diseases. Here, we will provide an update on the current status of these novel therapeutic opportunities. J. Cell. Physiol. 218: 9-12, 2009. (c) 2008 Wiley-Liss, Inc.",
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The use of mesenchymal (skeletal) stem cells for treatment of degenerative diseases: current status and future perspectives. / Abdallah, Basem; Kassem, Moustapha.

In: Journal of Cellular Physiology, Vol. 218, No. 1, 01.01.2009, p. 9-12.

Research output: Contribution to journalJournal articleResearchpeer-review

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KW - Bone Regeneration

KW - Cardiovascular Diseases

KW - Cell Separation

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KW - Multipotent Stem Cells

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