The tumor suppressors pRB and p53 as regulators of adipocyte differentiation and function

Philip Hallenborg, Søren Feddersen, Lise Madsen, Karsten Kristiansen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

BACKGROUND: The retinoblastoma protein (pRB) and p53 are crucial members of regulatory networks controlling the cell cycle and apoptosis, and a hallmark of virtually all cancers is dysregulation of expression or function of pRB or p53. Although they are best known for their role in cancer development, it is now evident that both are implicated in metabolism and cellular development. OBJECTIVE/METHODS: To review the role of pRB and p53 in adipocyte differentiation and function emphasizing that pRB and p53, via their effects on adipocyte development and function, play a role in the regulation of energy metabolism and homeostasis. RESULTS/CONCLUSIONS: pRB is required for adipose conversion and also involved in determining its mitochondrial capacity. p53 inhibits adipogenesis and results suggest that it is involved in maintaining function of adipose tissue.
Original languageEnglish
JournalExpert Opinion On Therapeutic Targets
Volume13
Issue number2
Pages (from-to)235-246
Number of pages11
ISSN1472-8222
DOIs
Publication statusPublished - 1. Feb 2009

Fingerprint

Adipocytes
Tumors
Adipogenesis
Retinoblastoma Protein
Energy Metabolism
Adipose Tissue
Neoplasms
Cell Cycle
Homeostasis
Apoptosis
Metabolism
Cells
Tissue

Keywords

  • Adipocytes
  • Adipose Tissue
  • Animals
  • Apoptosis
  • Cell Cycle
  • Cell Differentiation
  • Energy Metabolism
  • Homeostasis
  • Humans
  • Retinoblastoma Protein
  • Tumor Suppressor Protein p53

Cite this

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title = "The tumor suppressors pRB and p53 as regulators of adipocyte differentiation and function",
abstract = "BACKGROUND: The retinoblastoma protein (pRB) and p53 are crucial members of regulatory networks controlling the cell cycle and apoptosis, and a hallmark of virtually all cancers is dysregulation of expression or function of pRB or p53. Although they are best known for their role in cancer development, it is now evident that both are implicated in metabolism and cellular development. OBJECTIVE/METHODS: To review the role of pRB and p53 in adipocyte differentiation and function emphasizing that pRB and p53, via their effects on adipocyte development and function, play a role in the regulation of energy metabolism and homeostasis. RESULTS/CONCLUSIONS: pRB is required for adipose conversion and also involved in determining its mitochondrial capacity. p53 inhibits adipogenesis and results suggest that it is involved in maintaining function of adipose tissue.",
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The tumor suppressors pRB and p53 as regulators of adipocyte differentiation and function. / Hallenborg, Philip; Feddersen, Søren; Madsen, Lise; Kristiansen, Karsten.

In: Expert Opinion On Therapeutic Targets, Vol. 13, No. 2, 01.02.2009, p. 235-246.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - The tumor suppressors pRB and p53 as regulators of adipocyte differentiation and function

AU - Hallenborg, Philip

AU - Feddersen, Søren

AU - Madsen, Lise

AU - Kristiansen, Karsten

PY - 2009/2/1

Y1 - 2009/2/1

N2 - BACKGROUND: The retinoblastoma protein (pRB) and p53 are crucial members of regulatory networks controlling the cell cycle and apoptosis, and a hallmark of virtually all cancers is dysregulation of expression or function of pRB or p53. Although they are best known for their role in cancer development, it is now evident that both are implicated in metabolism and cellular development. OBJECTIVE/METHODS: To review the role of pRB and p53 in adipocyte differentiation and function emphasizing that pRB and p53, via their effects on adipocyte development and function, play a role in the regulation of energy metabolism and homeostasis. RESULTS/CONCLUSIONS: pRB is required for adipose conversion and also involved in determining its mitochondrial capacity. p53 inhibits adipogenesis and results suggest that it is involved in maintaining function of adipose tissue.

AB - BACKGROUND: The retinoblastoma protein (pRB) and p53 are crucial members of regulatory networks controlling the cell cycle and apoptosis, and a hallmark of virtually all cancers is dysregulation of expression or function of pRB or p53. Although they are best known for their role in cancer development, it is now evident that both are implicated in metabolism and cellular development. OBJECTIVE/METHODS: To review the role of pRB and p53 in adipocyte differentiation and function emphasizing that pRB and p53, via their effects on adipocyte development and function, play a role in the regulation of energy metabolism and homeostasis. RESULTS/CONCLUSIONS: pRB is required for adipose conversion and also involved in determining its mitochondrial capacity. p53 inhibits adipogenesis and results suggest that it is involved in maintaining function of adipose tissue.

KW - Adipocytes

KW - Adipose Tissue

KW - Animals

KW - Apoptosis

KW - Cell Cycle

KW - Cell Differentiation

KW - Energy Metabolism

KW - Homeostasis

KW - Humans

KW - Retinoblastoma Protein

KW - Tumor Suppressor Protein p53

U2 - 10.1517/14712590802680141

DO - 10.1517/14712590802680141

M3 - Journal article

VL - 13

SP - 235

EP - 246

JO - Expert Opinion On Therapeutic Targets

JF - Expert Opinion On Therapeutic Targets

SN - 1472-8222

IS - 2

ER -