The slow component of oxygen uptake during intense, sub-maximal exercise in man is associated with additional fibre recruitment

Peter Krustrup, Karin Söderlund, Magni Mohr, Jens Bangsbo

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Single muscle fibre metabolites and pulmonary oxygen uptake (VO2) were measured during moderate and intense, sub-maximal exercise to test the hypothesis that additional fibre recruitment is associated with the slow component of VO2. Seven healthy, male subjects performed 20 min moderate (MOD, approximately 50% of VO(2,max)) and intense (INT, approximately 80% VO(2,max)) cycling at 70 rpm. Glycogen content decreased significantly in type I and IIa fibres during INT, but only in type I fibres during MOD. During INT, creatine phosphate (CP) content decreased significantly both in types I and II fibres in the first 3 min (DeltaCP: 16.0+/-2.7 and 16.8+/-4.7 mmol kg(-1) d.w., respectively) and in the next 3 min (DeltaCP: 16.2+/-4.9 and 25.7+/-6.7 mmol kg(-1) d.w., respectively) with no further change from 6-20 min. CP content was below the pre-exercise level (mean-1 SD) in 11, 37, 70 and 74% of the type I fibres after 0, 3, 6 and 20 min of INT, respectively, and in 13, 45, 83 and 74% of the type II fibres. During INT, VO2 increased significantly by 6+/-1 and 4+/-1% in the periods 3-6 and 6-20 min, respectively (Delta VO(2,(6-3 min)): 0.14+/-0.02 l min(-1)), whereas VO2 was unchanged from 3 to 20 min of MOD. Exponential fitting revealed a slow component of VO2 during INT that appeared after approximately 2.6 min and amounted to 0.24 l min(-1). The present study demonstrates that additional type I and II fibres are recruited with time during intense sub-maximal exercise in temporal association with a significant slow component of VO2.

Original languageEnglish
JournalPfluegers Archiv
Volume447
Issue number6
Pages (from-to)855-66
ISSN0031-6768
DOIs
Publication statusPublished - 2004

Keywords

  • Adult
  • Analysis of Variance
  • Humans
  • Male
  • Muscle Fibers, Skeletal
  • Oxygen
  • Oxygen Consumption
  • Physical Exertion
  • Pulmonary Ventilation
  • Comparative Study
  • Journal Article
  • Research Support, Non-U.S. Gov't

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