The risk of asthma is increased among women with polycystic ovary syndrome: a twin study

Louise Zierau, Howraman Meteran, Vibeke Backer, Svend Lindenberg, Axel Skytthe, Simon Francis Thomsen

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Abstract

Background: Recent registry studies have demonstrated a higher prevalence of asthma among women with polycystic ovary syndrome (PCOS). We aimed to assess the association and heritability of PCOS and asthma in a Danish twin cohort.

Methods: Data for 32 382 female twins from the Danish Twin Registry were included. Twins with PCOS were identified by searching the Danish National Patient Registry for International Classification of Diseases-10 code E28.2. Asthma was diagnosed by questionnaires.

Results: 103 (0.3%) women had a PCOS diagnosis. The risk of asthma was increased among women with PCOS compared with women without (18% versus 9%, respectively; OR 2.11 (95% CI 1.13-3.96); p=0.02). After adjustment for age, body mass index, alcohol consumption and smoking status, the risk of asthma was still increased, but was no longer statistically significant (OR 1.54 (95% CI 0.75-3.17); p=0.24). Variance components analysis showed that shared environmental factors explained 49% (95% CI 24-68%) and unique environmental factors explained 51% (95% CI 32-76%) of the susceptibility to PCOS. For asthma, 44% (95% CI 28-61%) of the variance was explained by genetic factors, whereas 25% (95% CI 11-38%) was ascribable to shared environmental factors and 31% (95% CI 26-36%) to unique environmental factors.

Conclusion: The risk of asthma is twice as high among female twins with PCOS. The individual susceptibility to PCOS is mainly due to environmental factors and not genetics.

Original languageEnglish
Article number00018-2018
JournalERJ Open Research
Volume5
Issue number3
Number of pages7
ISSN2312-0541
DOIs
Publication statusPublished - Jul 2019

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Twin Studies
Polycystic Ovary Syndrome
Registries
International Classification of Diseases
Alcohol Drinking
Body Mass Index
Smoking

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Zierau, Louise ; Meteran, Howraman ; Backer, Vibeke ; Lindenberg, Svend ; Skytthe, Axel ; Thomsen, Simon Francis. / The risk of asthma is increased among women with polycystic ovary syndrome : a twin study. In: ERJ Open Research. 2019 ; Vol. 5, No. 3.
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abstract = "Background: Recent registry studies have demonstrated a higher prevalence of asthma among women with polycystic ovary syndrome (PCOS). We aimed to assess the association and heritability of PCOS and asthma in a Danish twin cohort.Methods: Data for 32 382 female twins from the Danish Twin Registry were included. Twins with PCOS were identified by searching the Danish National Patient Registry for International Classification of Diseases-10 code E28.2. Asthma was diagnosed by questionnaires.Results: 103 (0.3{\%}) women had a PCOS diagnosis. The risk of asthma was increased among women with PCOS compared with women without (18{\%} versus 9{\%}, respectively; OR 2.11 (95{\%} CI 1.13-3.96); p=0.02). After adjustment for age, body mass index, alcohol consumption and smoking status, the risk of asthma was still increased, but was no longer statistically significant (OR 1.54 (95{\%} CI 0.75-3.17); p=0.24). Variance components analysis showed that shared environmental factors explained 49{\%} (95{\%} CI 24-68{\%}) and unique environmental factors explained 51{\%} (95{\%} CI 32-76{\%}) of the susceptibility to PCOS. For asthma, 44{\%} (95{\%} CI 28-61{\%}) of the variance was explained by genetic factors, whereas 25{\%} (95{\%} CI 11-38{\%}) was ascribable to shared environmental factors and 31{\%} (95{\%} CI 26-36{\%}) to unique environmental factors.Conclusion: The risk of asthma is twice as high among female twins with PCOS. The individual susceptibility to PCOS is mainly due to environmental factors and not genetics.",
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The risk of asthma is increased among women with polycystic ovary syndrome : a twin study. / Zierau, Louise; Meteran, Howraman; Backer, Vibeke; Lindenberg, Svend; Skytthe, Axel; Thomsen, Simon Francis.

In: ERJ Open Research, Vol. 5, No. 3, 00018-2018, 07.2019.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - The risk of asthma is increased among women with polycystic ovary syndrome

T2 - a twin study

AU - Zierau, Louise

AU - Meteran, Howraman

AU - Backer, Vibeke

AU - Lindenberg, Svend

AU - Skytthe, Axel

AU - Thomsen, Simon Francis

PY - 2019/7

Y1 - 2019/7

N2 - Background: Recent registry studies have demonstrated a higher prevalence of asthma among women with polycystic ovary syndrome (PCOS). We aimed to assess the association and heritability of PCOS and asthma in a Danish twin cohort.Methods: Data for 32 382 female twins from the Danish Twin Registry were included. Twins with PCOS were identified by searching the Danish National Patient Registry for International Classification of Diseases-10 code E28.2. Asthma was diagnosed by questionnaires.Results: 103 (0.3%) women had a PCOS diagnosis. The risk of asthma was increased among women with PCOS compared with women without (18% versus 9%, respectively; OR 2.11 (95% CI 1.13-3.96); p=0.02). After adjustment for age, body mass index, alcohol consumption and smoking status, the risk of asthma was still increased, but was no longer statistically significant (OR 1.54 (95% CI 0.75-3.17); p=0.24). Variance components analysis showed that shared environmental factors explained 49% (95% CI 24-68%) and unique environmental factors explained 51% (95% CI 32-76%) of the susceptibility to PCOS. For asthma, 44% (95% CI 28-61%) of the variance was explained by genetic factors, whereas 25% (95% CI 11-38%) was ascribable to shared environmental factors and 31% (95% CI 26-36%) to unique environmental factors.Conclusion: The risk of asthma is twice as high among female twins with PCOS. The individual susceptibility to PCOS is mainly due to environmental factors and not genetics.

AB - Background: Recent registry studies have demonstrated a higher prevalence of asthma among women with polycystic ovary syndrome (PCOS). We aimed to assess the association and heritability of PCOS and asthma in a Danish twin cohort.Methods: Data for 32 382 female twins from the Danish Twin Registry were included. Twins with PCOS were identified by searching the Danish National Patient Registry for International Classification of Diseases-10 code E28.2. Asthma was diagnosed by questionnaires.Results: 103 (0.3%) women had a PCOS diagnosis. The risk of asthma was increased among women with PCOS compared with women without (18% versus 9%, respectively; OR 2.11 (95% CI 1.13-3.96); p=0.02). After adjustment for age, body mass index, alcohol consumption and smoking status, the risk of asthma was still increased, but was no longer statistically significant (OR 1.54 (95% CI 0.75-3.17); p=0.24). Variance components analysis showed that shared environmental factors explained 49% (95% CI 24-68%) and unique environmental factors explained 51% (95% CI 32-76%) of the susceptibility to PCOS. For asthma, 44% (95% CI 28-61%) of the variance was explained by genetic factors, whereas 25% (95% CI 11-38%) was ascribable to shared environmental factors and 31% (95% CI 26-36%) to unique environmental factors.Conclusion: The risk of asthma is twice as high among female twins with PCOS. The individual susceptibility to PCOS is mainly due to environmental factors and not genetics.

U2 - 10.1183/23120541.00018-2018

DO - 10.1183/23120541.00018-2018

M3 - Journal article

C2 - 31544109

VL - 5

JO - ERJ Open Research

JF - ERJ Open Research

SN - 2312-0541

IS - 3

M1 - 00018-2018

ER -