The response to oestrogen deprivation of the cartilage collagen degradation marker, CTX-II, is unique compared with other markers of collagen turnover

Anne-Christine Bay-Jensen; Nadine C B Tabassi; Lene V Sondergaard; Thomas Levin Andersen; Frederik Dagnaes-Hansen; Patrick Garnero; Moustapha Kassem; Jean-Marie Delaissé

doi:10.1186/ar2596

The response to oestrogen deprivation of the cartilage collagen degradation marker, CTX-II, is unique compared with other markers of collagen turnover

Anne-Christine Bay-Jensen, Nadine C B Tabassi, Lene V Sondergaard, Thomas Levin Andersen, Frederik Dagnaes-Hansen, Patrick Garnero, Moustapha Kassem, Jean-Marie Delaissé

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

The urinary level of the type II collagen degradation marker CTX-II is increased in postmenopausal women and in ovariectomised rats, suggesting that oestrogen deprivation induces cartilage breakdown. Here we investigate whether this response to oestrogen is also true for other type II collagen turnover markers known to be affected in osteoarthritis, and whether it relates to its presence in specific areas of cartilage tissue.

Original language	English
Article number	R9
Journal	Arthritis Research & Therapy
Volume	11
Issue number	1
Number of pages	12
ISSN	1478-6362
DOIs	https://doi.org/10.1186/ar2596
Publication status	Published - 2009

Keywords

Adult
Aged
Animals
Biological Markers
Cartilage
Collagen Type II
Estradiol
Estrogens
Female
Humans
Knee
Middle Aged
Osteoarthritis
Ovariectomy
Peptide Fragments
Postmenopause
Rats
Rats, Sprague-Dawley

Documents & Links

10.1186/ar2596

http://arthritis-research.biomedcentral.com/articles/10.1186/ar2596

Cite this

Bay-Jensen, A.-C., Tabassi, N. C. B., Sondergaard, L. V., Levin Andersen, T., Dagnaes-Hansen, F., Garnero, P., Kassem, M., & Delaissé, J.-M. (2009). The response to oestrogen deprivation of the cartilage collagen degradation marker, CTX-II, is unique compared with other markers of collagen turnover. Arthritis Research & Therapy, 11(1), Article R9. https://doi.org/10.1186/ar2596

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title = "The response to oestrogen deprivation of the cartilage collagen degradation marker, CTX-II, is unique compared with other markers of collagen turnover",

abstract = "The urinary level of the type II collagen degradation marker CTX-II is increased in postmenopausal women and in ovariectomised rats, suggesting that oestrogen deprivation induces cartilage breakdown. Here we investigate whether this response to oestrogen is also true for other type II collagen turnover markers known to be affected in osteoarthritis, and whether it relates to its presence in specific areas of cartilage tissue.",

keywords = "Adult, Aged, Animals, Biological Markers, Cartilage, Collagen Type II, Estradiol, Estrogens, Female, Humans, Knee, Middle Aged, Osteoarthritis, Ovariectomy, Peptide Fragments, Postmenopause, Rats, Rats, Sprague-Dawley",

author = "Anne-Christine Bay-Jensen and Tabassi, {Nadine C B} and Sondergaard, {Lene V} and {Levin Andersen}, Thomas and Frederik Dagnaes-Hansen and Patrick Garnero and Moustapha Kassem and Jean-Marie Delaiss{\'e}",

year = "2009",

doi = "10.1186/ar2596",

language = "English",

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journal = "Arthritis Research & Therapy",

issn = "1478-6362",

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The response to oestrogen deprivation of the cartilage collagen degradation marker, CTX-II, is unique compared with other markers of collagen turnover. / Bay-Jensen, Anne-Christine; Tabassi, Nadine C B; Sondergaard, Lene V et al.
In: Arthritis Research & Therapy, Vol. 11, No. 1, R9, 2009.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - The response to oestrogen deprivation of the cartilage collagen degradation marker, CTX-II, is unique compared with other markers of collagen turnover

AU - Bay-Jensen, Anne-Christine

AU - Tabassi, Nadine C B

AU - Sondergaard, Lene V

AU - Levin Andersen, Thomas

AU - Dagnaes-Hansen, Frederik

AU - Garnero, Patrick

AU - Kassem, Moustapha

AU - Delaissé, Jean-Marie

PY - 2009

Y1 - 2009

N2 - The urinary level of the type II collagen degradation marker CTX-II is increased in postmenopausal women and in ovariectomised rats, suggesting that oestrogen deprivation induces cartilage breakdown. Here we investigate whether this response to oestrogen is also true for other type II collagen turnover markers known to be affected in osteoarthritis, and whether it relates to its presence in specific areas of cartilage tissue.

AB - The urinary level of the type II collagen degradation marker CTX-II is increased in postmenopausal women and in ovariectomised rats, suggesting that oestrogen deprivation induces cartilage breakdown. Here we investigate whether this response to oestrogen is also true for other type II collagen turnover markers known to be affected in osteoarthritis, and whether it relates to its presence in specific areas of cartilage tissue.

KW - Adult

KW - Aged

KW - Animals

KW - Biological Markers

KW - Cartilage

KW - Collagen Type II

KW - Estradiol

KW - Estrogens

KW - Female

KW - Humans

KW - Knee

KW - Middle Aged

KW - Osteoarthritis

KW - Ovariectomy

KW - Peptide Fragments

KW - Postmenopause

KW - Rats

KW - Rats, Sprague-Dawley

U2 - 10.1186/ar2596

DO - 10.1186/ar2596

M3 - Journal article

C2 - 20527083

SN - 1478-6362

VL - 11

JO - Arthritis Research & Therapy

JF - Arthritis Research & Therapy

IS - 1

M1 - R9

ER -

The response to oestrogen deprivation of the cartilage collagen degradation marker, CTX-II, is unique compared with other markers of collagen turnover

Abstract

Keywords

Documents & Links

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