The relationship between ultra-short telomeres, aging of articular cartilage and the development of human hip osteoarthritis

M Harbo, J M Delaisse, P Kjaersgaard-Andersen, F B Soerensen, S Koelvraa, L Bendix

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Ultra-short telomeres caused by stress-induced telomere shortening are suggested to induce chondrocyte senescence in human osteoarthritic knees. Here we have further investigated the role of ultra-short telomeres in the development of osteoarthritis (OA) and in aging of articular cartilage in human hips.
Original languageEnglish
JournalMechanisms of Ageing and Development
Volume134
Issue number9
Pages (from-to)367-372
ISSN0047-6374
DOIs
Publication statusPublished - 1. Sep 2013

Keywords

  • Aging
  • Chondrocytes
  • Osteoarthritis
  • Telomere length
  • Ultra-short telomeres

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