The relationship between ultra-short telomeres, aging of articular cartilage and the development of human hip osteoarthritis

M Harbo; J M Delaisse; P Kjaersgaard-Andersen; F B Soerensen; S Koelvraa; L Bendix

doi:10.1016/j.mad.2013.07.002

The relationship between ultra-short telomeres, aging of articular cartilage and the development of human hip osteoarthritis

M Harbo, J M Delaisse, P Kjaersgaard-Andersen, F B Soerensen, S Koelvraa, L Bendix

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Ultra-short telomeres caused by stress-induced telomere shortening are suggested to induce chondrocyte senescence in human osteoarthritic knees. Here we have further investigated the role of ultra-short telomeres in the development of osteoarthritis (OA) and in aging of articular cartilage in human hips.

Original language	English
Journal	Mechanisms of Ageing and Development
Volume	134
Issue number	9
Pages (from-to)	367-372
ISSN	0047-6374
DOIs	https://doi.org/10.1016/j.mad.2013.07.002
Publication status	Published - 1. Sep 2013

Keywords

Aging
Chondrocytes
Osteoarthritis
Telomere length
Ultra-short telomeres

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10.1016/j.mad.2013.07.002

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title = "The relationship between ultra-short telomeres, aging of articular cartilage and the development of human hip osteoarthritis",

abstract = "Ultra-short telomeres caused by stress-induced telomere shortening are suggested to induce chondrocyte senescence in human osteoarthritic knees. Here we have further investigated the role of ultra-short telomeres in the development of osteoarthritis (OA) and in aging of articular cartilage in human hips.",

keywords = "Aging, Chondrocytes, OA, Osteoarthritis, STELA, Telomere length, Ultra-short telomeres, osteoarthritis, single telomere length assay, Aging, Chondrocytes, Osteoarthritis, Telomere length, Ultra-short telomeres",

author = "M Harbo and Delaisse, {J M} and P Kjaersgaard-Andersen and Soerensen, {F B} and S Koelvraa and L Bendix",

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The relationship between ultra-short telomeres, aging of articular cartilage and the development of human hip osteoarthritis. / Harbo, M; Delaisse, J M ; Kjaersgaard-Andersen, P; Soerensen, F B; Koelvraa, S; Bendix, L.

In: Mechanisms of Ageing and Development, Vol. 134, No. 9, 01.09.2013, p. 367-372.

Research output: Contribution to journal › Journal article › Research › peer-review

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T1 - The relationship between ultra-short telomeres, aging of articular cartilage and the development of human hip osteoarthritis

AU - Harbo, M

AU - Delaisse, J M

AU - Kjaersgaard-Andersen, P

AU - Soerensen, F B

AU - Koelvraa, S

AU - Bendix, L

PY - 2013/9/1

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N2 - Ultra-short telomeres caused by stress-induced telomere shortening are suggested to induce chondrocyte senescence in human osteoarthritic knees. Here we have further investigated the role of ultra-short telomeres in the development of osteoarthritis (OA) and in aging of articular cartilage in human hips.

AB - Ultra-short telomeres caused by stress-induced telomere shortening are suggested to induce chondrocyte senescence in human osteoarthritic knees. Here we have further investigated the role of ultra-short telomeres in the development of osteoarthritis (OA) and in aging of articular cartilage in human hips.

KW - Aging

KW - Chondrocytes

KW - OA

KW - Osteoarthritis

KW - STELA

KW - Telomere length

KW - Ultra-short telomeres

KW - osteoarthritis

KW - single telomere length assay

KW - Aging

KW - Chondrocytes

KW - Osteoarthritis

KW - Telomere length

KW - Ultra-short telomeres

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DO - 10.1016/j.mad.2013.07.002

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