The proteomic signature of insulin-resistant human skeletal muscle reveals increased glycolytic and decreased mitochondrial enzymes

J Giebelstein, G Poschmann, K Højlund, W Schechinger, J W Dietrich, K Levin, H Beck-Nielsen, K Podwojski, K Stühler, H E Meyer, H H Klein

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The molecular mechanisms underlying insulin resistance in skeletal muscle are incompletely understood. Here, we aimed to obtain a global picture of changes in protein abundance in skeletal muscle in obesity and type 2 diabetes, and those associated with whole-body measures of insulin action.
Original languageEnglish
JournalDiabetologia
Volume55
Issue number4
Pages (from-to)1114-27
Number of pages14
ISSN0012-186X
DOIs
Publication statusPublished - 2012

Fingerprint

Skeletal Muscle
Insulin
Enzymes
Type 2 Diabetes Mellitus
Insulin Resistance
Proteins

Keywords

  • Diabetes Mellitus, Type 2
  • Female
  • Glucose Clamp Technique
  • Glycolysis
  • Humans
  • Insulin
  • Insulin Resistance
  • Male
  • Middle Aged
  • Mitochondria
  • Muscle, Skeletal
  • Obesity
  • Proteomics
  • Tandem Mass Spectrometry

Cite this

Giebelstein, J ; Poschmann, G ; Højlund, K ; Schechinger, W ; Dietrich, J W ; Levin, K ; Beck-Nielsen, H ; Podwojski, K ; Stühler, K ; Meyer, H E ; Klein, H H. / The proteomic signature of insulin-resistant human skeletal muscle reveals increased glycolytic and decreased mitochondrial enzymes. In: Diabetologia. 2012 ; Vol. 55, No. 4. pp. 1114-27.
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abstract = "The molecular mechanisms underlying insulin resistance in skeletal muscle are incompletely understood. Here, we aimed to obtain a global picture of changes in protein abundance in skeletal muscle in obesity and type 2 diabetes, and those associated with whole-body measures of insulin action.",
keywords = "Diabetes Mellitus, Type 2, Female, Glucose Clamp Technique, Glycolysis, Humans, Insulin, Insulin Resistance, Male, Middle Aged, Mitochondria, Muscle, Skeletal, Obesity, Proteomics, Tandem Mass Spectrometry",
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Giebelstein, J, Poschmann, G, Højlund, K, Schechinger, W, Dietrich, JW, Levin, K, Beck-Nielsen, H, Podwojski, K, Stühler, K, Meyer, HE & Klein, HH 2012, 'The proteomic signature of insulin-resistant human skeletal muscle reveals increased glycolytic and decreased mitochondrial enzymes', Diabetologia, vol. 55, no. 4, pp. 1114-27. https://doi.org/10.1007/s00125-012-2456-x

The proteomic signature of insulin-resistant human skeletal muscle reveals increased glycolytic and decreased mitochondrial enzymes. / Giebelstein, J; Poschmann, G; Højlund, K; Schechinger, W; Dietrich, J W; Levin, K; Beck-Nielsen, H; Podwojski, K; Stühler, K; Meyer, H E; Klein, H H.

In: Diabetologia, Vol. 55, No. 4, 2012, p. 1114-27.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - The proteomic signature of insulin-resistant human skeletal muscle reveals increased glycolytic and decreased mitochondrial enzymes

AU - Giebelstein, J

AU - Poschmann, G

AU - Højlund, K

AU - Schechinger, W

AU - Dietrich, J W

AU - Levin, K

AU - Beck-Nielsen, H

AU - Podwojski, K

AU - Stühler, K

AU - Meyer, H E

AU - Klein, H H

PY - 2012

Y1 - 2012

N2 - The molecular mechanisms underlying insulin resistance in skeletal muscle are incompletely understood. Here, we aimed to obtain a global picture of changes in protein abundance in skeletal muscle in obesity and type 2 diabetes, and those associated with whole-body measures of insulin action.

AB - The molecular mechanisms underlying insulin resistance in skeletal muscle are incompletely understood. Here, we aimed to obtain a global picture of changes in protein abundance in skeletal muscle in obesity and type 2 diabetes, and those associated with whole-body measures of insulin action.

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Glucose Clamp Technique

KW - Glycolysis

KW - Humans

KW - Insulin

KW - Insulin Resistance

KW - Male

KW - Middle Aged

KW - Mitochondria

KW - Muscle, Skeletal

KW - Obesity

KW - Proteomics

KW - Tandem Mass Spectrometry

U2 - 10.1007/s00125-012-2456-x

DO - 10.1007/s00125-012-2456-x

M3 - Journal article

VL - 55

SP - 1114

EP - 1127

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 4

ER -