The potential of microRNAs as biofluid markers of neurodegenerative diseases: a systematic review

P. B. Danborg; A. H. Simonsen; G. Waldemar; N. H. H. Heegaard

doi:10.3109/1354750x.2014.904001

The potential of microRNAs as biofluid markers of neurodegenerative diseases: a systematic review

P. B. Danborg
, A. H. Simonsen
, G. Waldemar
, N. H. H. Heegaard

KI, OUH, Research unit of Clinical Biochemistry (Odense)

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

MicroRNAs (miRNA) are biological molecules transcribed from non-protein coding regions of the genome, participating in regulating cellular processes. MiRNAs in biofluids may possess neurodegenerative disease biomarker potential for screening tests, differential diagnosis and disease progression monitoring. This systematic review clarifies biomarker potential of miRNAs detected in biofluids of neurodegenerative disease patients. Thirty-three and ten miRNAs displayed significant expression between patients with multiple sclerosis and Alzheimer's disease, respectively, compared to healthy controls in minimum two studies. Thirty-eight miRNAs showed biomarker potential by distinguishing significantly between minimum two diseases. Summarized data directs future research towards discovering new biomarkers for neurodegenerative diseases.

Original language	English
Journal	Biomarkers
Volume	19
Issue number	4
Pages (from-to)	259-268
ISSN	1354-750X
DOIs	https://doi.org/10.3109/1354750x.2014.904001
Publication status	Published - 2014

Keywords

Alzheimer's disease amyotrophic lateral sclerosis biofluid markers microRNA multiple sclerosis Parkinson's disease MULTIPLE-SCLEROSIS PATIENTS ALZHEIMERS-DISEASE CEREBROSPINAL-FLUID CIRCULATING MICRORNAS LUPUS-ERYTHEMATOSUS EXPRESSION ANALYSIS RNA EXPRESSION BIOMARKERS BRAIN MIRNAS

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Cite this

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title = "The potential of microRNAs as biofluid markers of neurodegenerative diseases: a systematic review",

abstract = "MicroRNAs (miRNA) are biological molecules transcribed from non-protein coding regions of the genome, participating in regulating cellular processes. MiRNAs in biofluids may possess neurodegenerative disease biomarker potential for screening tests, differential diagnosis and disease progression monitoring. This systematic review clarifies biomarker potential of miRNAs detected in biofluids of neurodegenerative disease patients. Thirty-three and ten miRNAs displayed significant expression between patients with multiple sclerosis and Alzheimer's disease, respectively, compared to healthy controls in minimum two studies. Thirty-eight miRNAs showed biomarker potential by distinguishing significantly between minimum two diseases. Summarized data directs future research towards discovering new biomarkers for neurodegenerative diseases.",

keywords = "Alzheimer's disease amyotrophic lateral sclerosis biofluid markers microRNA multiple sclerosis Parkinson's disease MULTIPLE-SCLEROSIS PATIENTS ALZHEIMERS-DISEASE CEREBROSPINAL-FLUID CIRCULATING MICRORNAS LUPUS-ERYTHEMATOSUS EXPRESSION ANALYSIS RNA EXPRESSION BIOMARKERS BRAIN MIRNAS",

author = "Danborg, \{P. B.\} and Simonsen, \{A. H.\} and G. Waldemar and Heegaard, \{N. H. H.\}",

note = "ISI Document Delivery No.: AI3AI Times Cited: 3 Cited Reference Count: 86 Danborg, Pia B. Simonsen, Anja H. Waldemar, Gunhild Heegaard, Niels H. H. Simonsen, Anja/M-3834-2014 Danish Advanced Technology Foundation This work was supported by funding from the 'Patient-specific stem cell-derived models for Alzheimer's disease' project by the Danish Advanced Technology Foundation (Gunhild Waldemar). 3 INFORMA HEALTHCARE LONDON BIOMARKERS",

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doi = "10.3109/1354750x.2014.904001",

language = "English",

volume = "19",

pages = "259--268",

journal = "Biomarkers",

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T1 - The potential of microRNAs as biofluid markers of neurodegenerative diseases

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AU - Danborg, P. B.

AU - Simonsen, A. H.

AU - Waldemar, G.

AU - Heegaard, N. H. H.

N1 - ISI Document Delivery No.: AI3AI Times Cited: 3 Cited Reference Count: 86 Danborg, Pia B. Simonsen, Anja H. Waldemar, Gunhild Heegaard, Niels H. H. Simonsen, Anja/M-3834-2014 Danish Advanced Technology Foundation This work was supported by funding from the 'Patient-specific stem cell-derived models for Alzheimer's disease' project by the Danish Advanced Technology Foundation (Gunhild Waldemar). 3 INFORMA HEALTHCARE LONDON BIOMARKERS

PY - 2014

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N2 - MicroRNAs (miRNA) are biological molecules transcribed from non-protein coding regions of the genome, participating in regulating cellular processes. MiRNAs in biofluids may possess neurodegenerative disease biomarker potential for screening tests, differential diagnosis and disease progression monitoring. This systematic review clarifies biomarker potential of miRNAs detected in biofluids of neurodegenerative disease patients. Thirty-three and ten miRNAs displayed significant expression between patients with multiple sclerosis and Alzheimer's disease, respectively, compared to healthy controls in minimum two studies. Thirty-eight miRNAs showed biomarker potential by distinguishing significantly between minimum two diseases. Summarized data directs future research towards discovering new biomarkers for neurodegenerative diseases.

AB - MicroRNAs (miRNA) are biological molecules transcribed from non-protein coding regions of the genome, participating in regulating cellular processes. MiRNAs in biofluids may possess neurodegenerative disease biomarker potential for screening tests, differential diagnosis and disease progression monitoring. This systematic review clarifies biomarker potential of miRNAs detected in biofluids of neurodegenerative disease patients. Thirty-three and ten miRNAs displayed significant expression between patients with multiple sclerosis and Alzheimer's disease, respectively, compared to healthy controls in minimum two studies. Thirty-eight miRNAs showed biomarker potential by distinguishing significantly between minimum two diseases. Summarized data directs future research towards discovering new biomarkers for neurodegenerative diseases.

KW - Alzheimer's disease amyotrophic lateral sclerosis biofluid markers microRNA multiple sclerosis Parkinson's disease MULTIPLE-SCLEROSIS PATIENTS ALZHEIMERS-DISEASE CEREBROSPINAL-FLUID CIRCULATING MICRORNAS LUPUS-ERYTHEMATOSUS EXPRESSION ANALYSIS RNA EXPRESS

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DO - 10.3109/1354750x.2014.904001

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