The longevity gender gap: Are telomeres the explanation?

Abraham Aviv, Jerry Shay, Kaare Christensen, Woodring Wright

Research output: Contribution to journalJournal articleResearchpeer-review


In this Perspective, we focus on the greater longevity of women as compared with men. We propose that, like aging itself, the longevity gender gap is exceedingly complex and argue that it may arise from sex-related hormonal differences and from somatic cell selection that favors cells more resistant to the ravages of time. We discuss the interplay of these factors with telomere biology and oxidative stress and suggest that an explanation for the longevity gender gap may arise from a better understanding of the differences in telomere dynamics between men and women.
Original languageEnglish
JournalScience of aging knowledge environment
Issue number23
Pages (from-to)pe16
Publication statusPublished - 8. Jun 2005


  • Aged
  • Aging
  • Cardiovascular Diseases
  • Cell Survival
  • Chromosomes, Human, X
  • Chromosomes, Human, Y
  • Estrogens
  • Female
  • Humans
  • Longevity
  • Male
  • Middle Aged
  • Oxidative Stress
  • Sex Factors
  • Telomere

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