The interrelation between hypothyroidism and glaucoma: A critical review and meta-analysis

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The literature reports conflicting results on the association between hypothyroidism and glaucoma. We sought to clarify this by conducting a critical review and meta-analyses. Based on an electronic PubMed search, using the Medical Subject Heading terms hypothyroidism, myxoedema and glaucoma or intra ocular pressure, case-control studies, cohort studies and cross sectional studies were identified and reviewed. Using meta-analysis, the relative risk (RR) of co-existence of glaucoma and hypothyroidism was calculated. 12 studies fulfilled the inclusion criteria and could be categorized into two groups based on the exposure. The group with glaucoma (5679 patients) as exposure and hypothyroidism as outcome comprised eight studies. Among these, we found a non-significantly increased risk of hypothyroidism associated with glaucoma (RR 1.65; 95% confidence interval [CI]: 0.97-2.82). Based on 4 studies (165,980 patients) with hypothyroidism as exposure and glaucoma as outcome, we found the risk of glaucoma to be significantly increased (RR 1.39; 95% CI: 1.08-1.78). Based on these meta-analyses, there seems to be an association between hypothyroidism and glaucoma. However, larger scale studies with better phenotype classifications, longer follow-up time and taking co-morbidity and other biases into consideration are needed to address a potential causal relationship.
Original languageEnglish
Article number558
Issue numberS1
Pages (from-to)A222-A223
Publication statusPublished - 2015
EventInternational Thyroid Congress - Walt Disney World Swan and Dolphin Resort, Orlando, United States
Duration: 18. Oct 201523. Oct 2015


ConferenceInternational Thyroid Congress
LocationWalt Disney World Swan and Dolphin Resort
Country/TerritoryUnited States

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