The influence of transmitted and non-transmitted parental BMI-associated alleles on the risk of overweight in childhood

Theresia M. Schnurr; Camilla S. Morgen; Dmitrii Borisevich; Robin N. Beaumont; Line Engelbrechtsen; Lars Ängquist; Christian T. Have; Rachel M. Freathy; George Davey Smith; Ellen A. Nohr; Torben Hansen; Thorkild I.A. Sørensen

doi:10.1038/s41598-020-61719-3

The influence of transmitted and non-transmitted parental BMI-associated alleles on the risk of overweight in childhood

Theresia M. Schnurr^*
, Camilla S. Morgen
, Dmitrii Borisevich
, Robin N. Beaumont
, Line Engelbrechtsen
, Lars Ängquist
, Christian T. Have
, Rachel M. Freathy
, George Davey Smith
, Ellen A. Nohr
, Torben Hansen
, Thorkild I.A. Sørensen

^*Corresponding author for this work

University of Copenhagen
University of Exeter
University of Bristol
Herlev Hospital

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Overweight in children is strongly associated with parental body mass index (BMI) and overweight. We assessed parental transmitted and non-transmitted genetic contributions to overweight in children from the Danish National Birth Cohort by constructing genetic risk scores (GRSs) from 941 common genetic variants associated with adult BMI and estimating associations of transmitted maternal/paternal and non-transmitted maternal GRS with child overweight. Maternal and paternal BMI (standard deviation (SD) units) had a strong association with childhood overweight [Odds ratio (OR): 2.01 (95% confidence interval (CI) 1.74; 2.34) and 1.64 (95% CI 1.43; 1.89)]. Maternal and paternal transmitted GRSs (SD-units) increased odds for child overweight equally [OR: 1.30 (95% CI 1.16; 1.46) and 1.30 (95% CI 1.16; 1.47)]. However, both the parental phenotypic and the GRS associations may depend on maternal BMI, being weaker among mothers with overweight. Maternal non-transmitted GRS was not associated with child overweight [OR 0.98 (95% CI 0.88; 1.10)] suggesting no specific influence of maternal adiposity as such. In conclusion, parental transmitted GRSs, based on adult BMI, contribute to child overweight, but in overweight mothers other genetic and environmental factors may play a greater role.

Original language	English
Article number	4806
Journal	Scientific Reports
Volume	10
Number of pages	10
ISSN	2045-2322
DOIs	https://doi.org/10.1038/s41598-020-61719-3
Publication status	Published - 16. Mar 2020

Funding

We are thankful for all mothers and children that have contributed with their time and effort in order to establish this unique data source for research. The Danish National Birth Cohort was established with a grant from the Danish National Research Foundation. Additional support was obtained from the Danish Regional Committees, the Pharmacy Foundation, the Egmont Foundation, the March of Dimes Birth Defects Foundation, the Health Foundation and other minor grants. The Danish National Birth Cohort Biobank has been supported by the Novo Nordisk Foundation and the Lundbeck Foundation. Follow-up of mothers and children at 7 years have been supported by the Danish Medical Research Council (SSVF 0646) and the Lundbeck Foundation (195/04). The Novo Nordisk Foundation Centre for Basic Metabolic Research is an independent research centre at the University of Copenhagen partially funded by an unrestricted donation from the Novo Nordisk Foundation (http://metabol.ku.dk). This project was supported by the Danish Council for Independent Research (DFF-7016-00381). RNB and RMF were both funded by a Wellcome Trust and Royal Society grant (WT104150).

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Open Access VersionFinal published version, 1.16 MBLicence: CC BY

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Schnurr, T. M., Morgen, C. S., Borisevich, D., Beaumont, R. N., Engelbrechtsen, L., Ängquist, L., Have, C. T., Freathy, R. M., Smith, G. D., Nohr, E. A., Hansen, T., & Sørensen, T. I. A. (2020). The influence of transmitted and non-transmitted parental BMI-associated alleles on the risk of overweight in childhood. Scientific Reports, 10, Article 4806. https://doi.org/10.1038/s41598-020-61719-3

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title = "The influence of transmitted and non-transmitted parental BMI-associated alleles on the risk of overweight in childhood",

abstract = "Overweight in children is strongly associated with parental body mass index (BMI) and overweight. We assessed parental transmitted and non-transmitted genetic contributions to overweight in children from the Danish National Birth Cohort by constructing genetic risk scores (GRSs) from 941 common genetic variants associated with adult BMI and estimating associations of transmitted maternal/paternal and non-transmitted maternal GRS with child overweight. Maternal and paternal BMI (standard deviation (SD) units) had a strong association with childhood overweight [Odds ratio (OR): 2.01 (95\% confidence interval (CI) 1.74; 2.34) and 1.64 (95\% CI 1.43; 1.89)]. Maternal and paternal transmitted GRSs (SD-units) increased odds for child overweight equally [OR: 1.30 (95\% CI 1.16; 1.46) and 1.30 (95\% CI 1.16; 1.47)]. However, both the parental phenotypic and the GRS associations may depend on maternal BMI, being weaker among mothers with overweight. Maternal non-transmitted GRS was not associated with child overweight [OR 0.98 (95\% CI 0.88; 1.10)] suggesting no specific influence of maternal adiposity as such. In conclusion, parental transmitted GRSs, based on adult BMI, contribute to child overweight, but in overweight mothers other genetic and environmental factors may play a greater role.",

author = "Schnurr, \{Theresia M.\} and Morgen, \{Camilla S.\} and Dmitrii Borisevich and Beaumont, \{Robin N.\} and Line Engelbrechtsen and Lars {\"A}ngquist and Have, \{Christian T.\} and Freathy, \{Rachel M.\} and Smith, \{George Davey\} and Nohr, \{Ellen A.\} and Torben Hansen and S{\o}rensen, \{Thorkild I.A.\}",

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doi = "10.1038/s41598-020-61719-3",

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T1 - The influence of transmitted and non-transmitted parental BMI-associated alleles on the risk of overweight in childhood

AU - Schnurr, Theresia M.

AU - Morgen, Camilla S.

AU - Borisevich, Dmitrii

AU - Beaumont, Robin N.

AU - Engelbrechtsen, Line

AU - Ängquist, Lars

AU - Have, Christian T.

AU - Freathy, Rachel M.

AU - Smith, George Davey

AU - Nohr, Ellen A.

AU - Hansen, Torben

AU - Sørensen, Thorkild I.A.

PY - 2020/3/16

Y1 - 2020/3/16

N2 - Overweight in children is strongly associated with parental body mass index (BMI) and overweight. We assessed parental transmitted and non-transmitted genetic contributions to overweight in children from the Danish National Birth Cohort by constructing genetic risk scores (GRSs) from 941 common genetic variants associated with adult BMI and estimating associations of transmitted maternal/paternal and non-transmitted maternal GRS with child overweight. Maternal and paternal BMI (standard deviation (SD) units) had a strong association with childhood overweight [Odds ratio (OR): 2.01 (95% confidence interval (CI) 1.74; 2.34) and 1.64 (95% CI 1.43; 1.89)]. Maternal and paternal transmitted GRSs (SD-units) increased odds for child overweight equally [OR: 1.30 (95% CI 1.16; 1.46) and 1.30 (95% CI 1.16; 1.47)]. However, both the parental phenotypic and the GRS associations may depend on maternal BMI, being weaker among mothers with overweight. Maternal non-transmitted GRS was not associated with child overweight [OR 0.98 (95% CI 0.88; 1.10)] suggesting no specific influence of maternal adiposity as such. In conclusion, parental transmitted GRSs, based on adult BMI, contribute to child overweight, but in overweight mothers other genetic and environmental factors may play a greater role.

AB - Overweight in children is strongly associated with parental body mass index (BMI) and overweight. We assessed parental transmitted and non-transmitted genetic contributions to overweight in children from the Danish National Birth Cohort by constructing genetic risk scores (GRSs) from 941 common genetic variants associated with adult BMI and estimating associations of transmitted maternal/paternal and non-transmitted maternal GRS with child overweight. Maternal and paternal BMI (standard deviation (SD) units) had a strong association with childhood overweight [Odds ratio (OR): 2.01 (95% confidence interval (CI) 1.74; 2.34) and 1.64 (95% CI 1.43; 1.89)]. Maternal and paternal transmitted GRSs (SD-units) increased odds for child overweight equally [OR: 1.30 (95% CI 1.16; 1.46) and 1.30 (95% CI 1.16; 1.47)]. However, both the parental phenotypic and the GRS associations may depend on maternal BMI, being weaker among mothers with overweight. Maternal non-transmitted GRS was not associated with child overweight [OR 0.98 (95% CI 0.88; 1.10)] suggesting no specific influence of maternal adiposity as such. In conclusion, parental transmitted GRSs, based on adult BMI, contribute to child overweight, but in overweight mothers other genetic and environmental factors may play a greater role.

U2 - 10.1038/s41598-020-61719-3

DO - 10.1038/s41598-020-61719-3

M3 - Journal article

C2 - 32179833

AN - SCOPUS:85082024653

SN - 2045-2322

VL - 10

JO - Scientific Reports

JF - Scientific Reports

M1 - 4806

ER -

The influence of transmitted and non-transmitted parental BMI-associated alleles on the risk of overweight in childhood

Abstract

Funding

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