The global antiphospholipid syndrome score in women with systemic lupus erythematosus and adverse pregnancy outcomes

Karen Schreiber, Massimo Radin, Irene Cecchi, Elena Rubini, Dario Roccatello, Søren Jacobsen, Maria J Cuadrado, Savino Sciascia*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

OBJECTIVES: To validate the global antiphospholipid syndrome score (GAPSS) in a cohort of women with systemic lupus erythematosus (SLE) and antiphospholipid antibodies (aPL).

METHODS: This retrospective study included 143 women ever pregnant with SLE who presented in our outpatient clinic were included. Data on cardiovascular risk factors and aPL status were retrospectively collected and their individual GAPSS score was calculated.

RESULTS: Significantly higher GAPSS values were found in women with any placental medicated complication (such as foetal death, placental abruption, prematurity, pre-eclampsia or intrauterine growth restriction (IUGR)) (GAPSS 8.2±3.0 vs. 3.5±3.0, p<0.001). Significantly higher GAPSS values were also found in those with recurrent miscarriages (RM) <10 weeks, foetal death, placental abruption, prematurity, pre-eclampsia or IUGR) (GAPSS 8.3±4.5 vs. 3.2±2.6, p<0.001). Patients with 3 or more consecutive early miscarriages (<10 weeks), foetal death, miscarriage <10 weeks' gestation, premature birth (<34 weeks), pre-eclampsia (<34 weeks), stillbirth, and placental infarction had significantly higher GAPSS values compared to those without previous pregnancy complications. The odds ratio of having any pregnancy morbidity when having a GAPSS value ≥8 was 20 compared to those with a GAPSS of ≤1 (p<0.001).

CONCLUSIONS: Women with a history of aPL-related pregnancy complications had higher GAPSS values in this retrospective cohort compared to women without pregnancy complications. This study is the first step to assess the clinical utility of the GAPSS score in pregnancy. A prospective validation is needed.

Original languageEnglish
Article numberCER13730
JournalClinical and Experimental Rheumatology
Volume39
Issue number5
Pages (from-to)1071-1076
ISSN0392-856X
DOIs
Publication statusPublished - 31. Aug 2021

Keywords

  • Antiphospholipid Syndrome/complications
  • Female
  • Humans
  • Lupus Erythematosus, Systemic/complications
  • Placenta
  • Pregnancy
  • Pregnancy Complications/diagnosis
  • Pregnancy Outcome/epidemiology
  • Retrospective Studies
  • global antiphospholipid syndrome score
  • pregnancy morbidity
  • pregnancy
  • antiphospholipid syndrome
  • systemic lupus erythematosus
  • pregnancy complications

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