The first woman to give birth to two children following transplantation of frozen/thawed ovarian tissue

Erik Ernst, Stinne Bergholdt, Jan Stener Jørgensen, Claus Yding Andersen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Worldwide eight children have been born as a result of transplanting frozen/thawed ovarian tissue. Two of these children were born in Denmark following transport of the ovarian tissue for a period of 5 h prior to cryopreservation. One of these women, who was originally transplanted with six pieces of ovarian cortex, after having experienced a period of menopause has now conceived again following natural conception. She gave birth to a healthy girl on 23 September 2008 and is therefore the first woman in the world to have had two children, from separate pregnancies, born as a result of transplanting frozen/thawed ovarian tissue. This result encourages further development of cryopreservation of ovarian tissue for fertility preservation as a clinical procedure for girls and young women facing gonadotoxic treatment.
Original languageEnglish
JournalHuman Reproduction
Volume25
Issue number5
Pages (from-to)1280-1
Number of pages2
ISSN0268-1161
DOIs
Publication statusPublished - 1. May 2010

Keywords

  • Adult
  • Cryopreservation
  • Denmark
  • Female
  • Fertility
  • Humans
  • Infant, Newborn
  • Ovary
  • Pregnancy
  • Pregnancy Complications, Neoplastic
  • Pregnancy Outcome
  • Sarcoma, Ewing's
  • Time Factors
  • Transplantation, Autologous

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