The emerging role of one-carbon metabolism in T cells

Henry Kurniawan, Takumi Kobayashi, Dirk Brenner

Research output: Contribution to journalJournal articleResearchpeer-review

34 Downloads (Pure)

Abstract

One-carbon metabolism (1CM) supports multiple biological functions, providing 1C units for nucleotide synthesis, epigenetic maintenance, and redox regulation. Although much has been deciphered about the relationship between disruption of 1CM and various diseases, our understanding of 1CM's involvement in the regulation of the immune system is only now evolving. In this review, we summarize key checkpoints of 1CM pathways that govern cellular activities. We also report on recent findings regarding the role of 1CM in T cells and discuss several promising avenues requiring future investigation.

Original languageEnglish
JournalCurrent Opinion in Biotechnology
Volume68
Pages (from-to)193-201
ISSN0958-1669
DOIs
Publication statusPublished - Apr 2021

Fingerprint Dive into the research topics of 'The emerging role of one-carbon metabolism in T cells'. Together they form a unique fingerprint.

Cite this