The Effects of Lifestyle and/or Vitamin D Supplementation Interventions on Pregnancy Outcomes: What Have We Learned from the DALI Studies?

Jürgen Harreiter, Gernot Desoye, Mireille N M van Poppel, Alexandra Kautzky-Willer, Fidelma Dunne, Rosa Corcoy, Roland Devlieger, David Simmons, Juan M Adelantado, Peter Damm, Elizabeth Reinhardt Mathiesen, Dorte Moeller Jensen, Lise Lotte T Anderson, Annunziata Lapolla, Maria G Dalfrà, Alessandra Bertolotto, Ewa Wender-Ozegowska, Agnieszka Zawiejska, David J Hill, Frank J SnoekDALI consortium

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

PURPOSE OF REVIEW: The DALI (vitamin D and lifestyle intervention in the prevention of gestational diabetes mellitus (GDM)) study aimed to prevent GDM with lifestyle interventions or Vitamin D supplementation (1600 IU/day). This review summarizes the learnings from the DALI studies among pregnant women with a BMI ≥ 29 kg/m2.

RECENT FINDINGS: Women diagnosed with GDM earlier in pregnancy had a worse metabolic profile than those diagnosed later. A combined physical activity (PA) and healthy eating (HE) lifestyle intervention improved both behaviours, limited gestational weight gain (GWG) and was cost-effective. Although GDM risk was unchanged, neonatal adiposity was reduced due to less sedentary time. Neither PA nor HE alone limited GWG or GDM risk. Fasting glucose was higher with HE only intervention, and lower with Vitamin D supplementation. Our combined intervention did not prevent GDM, but was cost-effective, limited GWG and reduced neonatal adiposity.

Original languageEnglish
Article number162
JournalCurrent Diabetes Reports
Volume19
Issue number12
Number of pages10
ISSN1534-4827
DOIs
Publication statusPublished - 16. Dec 2019

Keywords

  • Gestational diabetes mellitus
  • Lifestyle intervention
  • Obesity
  • Prevention pregnancy
  • Vitamin D

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