The effect of metrizamide on regional brain glucose metabolism in the rat

L Bech, N H Diemer, A Gjedde

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The X-ray contrast material metrizamide is structurally related to 2-deoxyglucose and inhibits brain glucose phosphorylation in vitro. In vivo, the present autoradiographic study with labeled 2-deoxyglucose revealed a global reduction of brain glucose phosphorylation after metrizamide administration in the cisterna magna of rats. The reduction averaged 18% of all regions.

Original languageEnglish
Book seriesActa Neurologica Scandinavica
Volume69
Issue number4
Pages (from-to)249-53
ISSN0001-6314
DOIs
Publication statusPublished - Apr 1984
Externally publishedYes

Keywords

  • Animals
  • Brain/metabolism
  • Cisterna Magna
  • Deoxy Sugars/metabolism
  • Deoxyglucose/metabolism
  • Male
  • Metrizamide/administration & dosage
  • Oxidative Phosphorylation/drug effects
  • Rats
  • Rats, Inbred Strains

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