The effect of BRAFV600E mutation on survival and treatment efficacy in vulnerable older patients with metastatic colorectal cancer – A post-hoc exploratory analysis of the randomized NORDIC9-study

Gabor Liposits; Stine B. Winther; Jesper Ryg; Halla Skuladottir; Sören Möller; Eva Hofsli; Carl Henrik Shah; Laurids Østergaard Poulsen; Åke Berglund; Camilla Qvortrup; Pia Osterlund; Bengt Glimelius; Halfdan Sorbye; Per Pfeiffer

doi:10.1016/j.jgo.2023.101632

The effect of BRAF^V600E mutation on survival and treatment efficacy in vulnerable older patients with metastatic colorectal cancer – A post-hoc exploratory analysis of the randomized NORDIC9-study

Gabor Liposits^*, Stine B. Winther, Jesper Ryg, Halla Skuladottir, Sören Möller, Eva Hofsli, Carl Henrik Shah, Laurids Østergaard Poulsen, Åke Berglund, Camilla Qvortrup, Pia Osterlund, Bengt Glimelius, Halfdan Sorbye, Per Pfeiffer

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

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Original language	English
Article number	101632
Journal	Journal of Geriatric Oncology
Volume	15
Issue number	2
Number of pages	4
ISSN	1879-4068
DOIs	https://doi.org/10.1016/j.jgo.2023.101632
Publication status	Published - Mar 2024

Keywords

BRAF
Chemotherapy
Colorectal cancer
Frailty
Older adults
Survival
Humans
Proto-Oncogene Proteins B-raf/genetics
Treatment Outcome
Colorectal Neoplasms/drug therapy
Rectal Neoplasms
Mutation
Colonic Neoplasms

Documents & Links

10.1016/j.jgo.2023.101632Licence: CC BY

NORDIC9_BRAFV600E_JGO_2023Proof, 842 KBLicence: CC BY
Open Access VersionFinal published version, 850 KBLicence: CC BY

1 Ph.D. thesis

Quality of life, prognostic and predictive factors in vulnerable older patients with metastatic colorectal cancer receiving palliative chemotherapy: The randomized NORDIC9-study
Liposits, G., 13. Mar 2024, Syddansk Universitet. Det Sundhedsvidenskabelige Fakultet. 189 p.
Research output: Thesis › Ph.D. thesis

Open Access
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85 Downloads (Pure)

1 Finished

Nordic9-study
Liposits, G. I. (PhD student), Pfeiffer, P. (Supervisor), Winther, S. B. (Co-supervisor), Ryg, J. (Co-supervisor) & Skuladottir, H. (Co-supervisor)
01/09/2020 → 31/12/2023
Project: PhD Project

Cite this

Liposits, G., Winther, S. B., Ryg, J., Skuladottir, H., Möller, S., Hofsli, E., Shah, C. H., Poulsen, L. Ø., Berglund, Å., Qvortrup, C., Osterlund, P., Glimelius, B., Sorbye, H., & Pfeiffer, P. (2024). The effect of BRAF^V600E mutation on survival and treatment efficacy in vulnerable older patients with metastatic colorectal cancer – A post-hoc exploratory analysis of the randomized NORDIC9-study. Journal of Geriatric Oncology, 15(2), Article 101632. https://doi.org/10.1016/j.jgo.2023.101632

@article{3532a2420d1a4259926288278fc02b0e,

title = "The effect of BRAFV600E mutation on survival and treatment efficacy in vulnerable older patients with metastatic colorectal cancer – A post-hoc exploratory analysis of the randomized NORDIC9-study",

keywords = "BRAF, Chemotherapy, Colorectal cancer, Frailty, Older adults, Survival, Humans, Proto-Oncogene Proteins B-raf/genetics, Treatment Outcome, Colorectal Neoplasms/drug therapy, Rectal Neoplasms, Mutation, Colonic Neoplasms",

author = "Gabor Liposits and Winther, {Stine B.} and Jesper Ryg and Halla Skuladottir and S{\"o}ren M{\"o}ller and Eva Hofsli and Shah, {Carl Henrik} and Poulsen, {Laurids {\O}stergaard} and {\AA}ke Berglund and Camilla Qvortrup and Pia Osterlund and Bengt Glimelius and Halfdan Sorbye and Per Pfeiffer",

note = "Funding Information: This investigator-initiated study was partly funded by Taiho Pharmaceuticals, Nordic Group, The Danish Cancer Society (grant number: R269-A15859), Academy of Geriatric Cancer Research (AgeCare), The Swedish Cancer Society and the Region of Southern Denmark. ",

year = "2024",

month = mar,

doi = "10.1016/j.jgo.2023.101632",

language = "English",

volume = "15",

journal = "Journal of Geriatric Oncology",

issn = "1879-4068",

publisher = "Elsevier",

number = "2",

}

Liposits, G, Winther, SB, Ryg, J, Skuladottir, H, Möller, S, Hofsli, E, Shah, CH, Poulsen, LØ, Berglund, Å, Qvortrup, C, Osterlund, P, Glimelius, B, Sorbye, H & Pfeiffer, P 2024, 'The effect of BRAF^V600E mutation on survival and treatment efficacy in vulnerable older patients with metastatic colorectal cancer – A post-hoc exploratory analysis of the randomized NORDIC9-study', Journal of Geriatric Oncology, vol. 15, no. 2, 101632. https://doi.org/10.1016/j.jgo.2023.101632

The effect of BRAF^V600E mutation on survival and treatment efficacy in vulnerable older patients with metastatic colorectal cancer – A post-hoc exploratory analysis of the randomized NORDIC9-study. / Liposits, Gabor; Winther, Stine B.; Ryg, Jesper et al.
In: Journal of Geriatric Oncology, Vol. 15, No. 2, 101632, 03.2024.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - The effect of BRAFV600E mutation on survival and treatment efficacy in vulnerable older patients with metastatic colorectal cancer – A post-hoc exploratory analysis of the randomized NORDIC9-study

AU - Liposits, Gabor

AU - Winther, Stine B.

AU - Ryg, Jesper

AU - Skuladottir, Halla

AU - Möller, Sören

AU - Hofsli, Eva

AU - Shah, Carl Henrik

AU - Poulsen, Laurids Østergaard

AU - Berglund, Åke

AU - Qvortrup, Camilla

AU - Osterlund, Pia

AU - Glimelius, Bengt

AU - Sorbye, Halfdan

AU - Pfeiffer, Per

N1 - Funding Information: This investigator-initiated study was partly funded by Taiho Pharmaceuticals, Nordic Group, The Danish Cancer Society (grant number: R269-A15859), Academy of Geriatric Cancer Research (AgeCare), The Swedish Cancer Society and the Region of Southern Denmark.

PY - 2024/3

Y1 - 2024/3

KW - BRAF

KW - Chemotherapy

KW - Colorectal cancer

KW - Frailty

KW - Older adults

KW - Survival

KW - Humans

KW - Proto-Oncogene Proteins B-raf/genetics

KW - Treatment Outcome

KW - Colorectal Neoplasms/drug therapy

KW - Rectal Neoplasms

KW - Mutation

KW - Colonic Neoplasms

U2 - 10.1016/j.jgo.2023.101632

DO - 10.1016/j.jgo.2023.101632

M3 - Journal article

C2 - 37730481

AN - SCOPUS:85171840049

SN - 1879-4068

VL - 15

JO - Journal of Geriatric Oncology

JF - Journal of Geriatric Oncology

IS - 2

M1 - 101632

ER -

The effect of BRAFV600E mutation on survival and treatment efficacy in vulnerable older patients with metastatic colorectal cancer – A post-hoc exploratory analysis of the randomized NORDIC9-study

Keywords

Documents & Links

Related research output

Quality of life, prognostic and predictive factors in vulnerable older patients with metastatic colorectal cancer receiving palliative chemotherapy: The randomized NORDIC9-study

Related projects

Nordic9-study

Cite this

The effect of BRAF^V600E mutation on survival and treatment efficacy in vulnerable older patients with metastatic colorectal cancer – A post-hoc exploratory analysis of the randomized NORDIC9-study