The Danish PEP Registry: Experience with the use of post-exposure prophylaxis following blood exposure to HIV from 1999-2012

Suzanne Lunding, Terese L Katzenstein, Gitte Kronborg, Merete Storgaard, Court Pedersen, Birgitte Mørn, Jens Å Lindberg, Thit M Kronborg, Janne Jensen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

BACKGROUND: The risk of occupational exposures to blood cannot be eliminated completely and access to post-exposure prophylaxis (PEP) to prevent HIV transmission is important. However, PEP administration has been associated with frequent adverse effects, low compliance and difficulties to ensure a proper risk assessment. This nationwide study describes 14 years of experience with the use of PEP following blood exposure in Denmark.

METHODS: A descriptive study of all PEP cases following non-sexual exposure to HIV in Denmark from 1999-2012.

RESULTS: A total of 411 cases of PEP were described. There was a mean of 29.4 cases/year, increasing from 23 cases in 1999 to 49 cases in 2005 and then decreasing to 16 cases in 2012. Overall 67.2% of source patients were known to be HIV-positive at the time of PEP initiation, with no significant change over time. The median time to initiation of PEP was 2.5 h (0.15-28.5) following occupational exposure. Adverse effects were reported by 50.9% with no significant difference according to PEP regimen. In 85.1% of cases with available data, either a full course of PEP was completed or PEP was stopped because the source was tested HIV-negative. Only 6.6% stopped PEP early due to adverse effects.

CONCLUSIONS: PEP in Denmark is generally prescribed according to the guidelines and the annual number of cases has declined since 2005. Adverse effects were common regardless of PEP regimens used and new drug regimens should be considered.

Original languageEnglish
JournalInfectious Diseases
Volume48
Issue number3
Pages (from-to)195-200
ISSN2374-4235
DOIs
Publication statusPublished - 2016

Fingerprint

Registries
HIV
Denmark
Occupational Exposure
Compliance
Guidelines

Cite this

Lunding, Suzanne ; Katzenstein, Terese L ; Kronborg, Gitte ; Storgaard, Merete ; Pedersen, Court ; Mørn, Birgitte ; Lindberg, Jens Å ; Kronborg, Thit M ; Jensen, Janne . / The Danish PEP Registry : Experience with the use of post-exposure prophylaxis following blood exposure to HIV from 1999-2012. In: Infectious Diseases. 2016 ; Vol. 48, No. 3. pp. 195-200.
@article{35a6ec7d397b4c5b81dfc03b3e8293d9,
title = "The Danish PEP Registry: Experience with the use of post-exposure prophylaxis following blood exposure to HIV from 1999-2012",
abstract = "BACKGROUND: The risk of occupational exposures to blood cannot be eliminated completely and access to post-exposure prophylaxis (PEP) to prevent HIV transmission is important. However, PEP administration has been associated with frequent adverse effects, low compliance and difficulties to ensure a proper risk assessment. This nationwide study describes 14 years of experience with the use of PEP following blood exposure in Denmark.METHODS: A descriptive study of all PEP cases following non-sexual exposure to HIV in Denmark from 1999-2012.RESULTS: A total of 411 cases of PEP were described. There was a mean of 29.4 cases/year, increasing from 23 cases in 1999 to 49 cases in 2005 and then decreasing to 16 cases in 2012. Overall 67.2{\%} of source patients were known to be HIV-positive at the time of PEP initiation, with no significant change over time. The median time to initiation of PEP was 2.5 h (0.15-28.5) following occupational exposure. Adverse effects were reported by 50.9{\%} with no significant difference according to PEP regimen. In 85.1{\%} of cases with available data, either a full course of PEP was completed or PEP was stopped because the source was tested HIV-negative. Only 6.6{\%} stopped PEP early due to adverse effects.CONCLUSIONS: PEP in Denmark is generally prescribed according to the guidelines and the annual number of cases has declined since 2005. Adverse effects were common regardless of PEP regimens used and new drug regimens should be considered.",
author = "Suzanne Lunding and Katzenstein, {Terese L} and Gitte Kronborg and Merete Storgaard and Court Pedersen and Birgitte M{\o}rn and Lindberg, {Jens {\AA}} and Kronborg, {Thit M} and Janne Jensen",
year = "2016",
doi = "10.3109/23744235.2015.1103896",
language = "English",
volume = "48",
pages = "195--200",
journal = "Infectious Diseases",
issn = "2374-4235",
publisher = "Taylor & Francis",
number = "3",

}

Lunding, S, Katzenstein, TL, Kronborg, G, Storgaard, M, Pedersen, C, Mørn, B, Lindberg, JÅ, Kronborg, TM & Jensen, J 2016, 'The Danish PEP Registry: Experience with the use of post-exposure prophylaxis following blood exposure to HIV from 1999-2012', Infectious Diseases, vol. 48, no. 3, pp. 195-200. https://doi.org/10.3109/23744235.2015.1103896

The Danish PEP Registry : Experience with the use of post-exposure prophylaxis following blood exposure to HIV from 1999-2012. / Lunding, Suzanne; Katzenstein, Terese L; Kronborg, Gitte; Storgaard, Merete; Pedersen, Court; Mørn, Birgitte; Lindberg, Jens Å; Kronborg, Thit M; Jensen, Janne .

In: Infectious Diseases, Vol. 48, No. 3, 2016, p. 195-200.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - The Danish PEP Registry

T2 - Experience with the use of post-exposure prophylaxis following blood exposure to HIV from 1999-2012

AU - Lunding, Suzanne

AU - Katzenstein, Terese L

AU - Kronborg, Gitte

AU - Storgaard, Merete

AU - Pedersen, Court

AU - Mørn, Birgitte

AU - Lindberg, Jens Å

AU - Kronborg, Thit M

AU - Jensen, Janne

PY - 2016

Y1 - 2016

N2 - BACKGROUND: The risk of occupational exposures to blood cannot be eliminated completely and access to post-exposure prophylaxis (PEP) to prevent HIV transmission is important. However, PEP administration has been associated with frequent adverse effects, low compliance and difficulties to ensure a proper risk assessment. This nationwide study describes 14 years of experience with the use of PEP following blood exposure in Denmark.METHODS: A descriptive study of all PEP cases following non-sexual exposure to HIV in Denmark from 1999-2012.RESULTS: A total of 411 cases of PEP were described. There was a mean of 29.4 cases/year, increasing from 23 cases in 1999 to 49 cases in 2005 and then decreasing to 16 cases in 2012. Overall 67.2% of source patients were known to be HIV-positive at the time of PEP initiation, with no significant change over time. The median time to initiation of PEP was 2.5 h (0.15-28.5) following occupational exposure. Adverse effects were reported by 50.9% with no significant difference according to PEP regimen. In 85.1% of cases with available data, either a full course of PEP was completed or PEP was stopped because the source was tested HIV-negative. Only 6.6% stopped PEP early due to adverse effects.CONCLUSIONS: PEP in Denmark is generally prescribed according to the guidelines and the annual number of cases has declined since 2005. Adverse effects were common regardless of PEP regimens used and new drug regimens should be considered.

AB - BACKGROUND: The risk of occupational exposures to blood cannot be eliminated completely and access to post-exposure prophylaxis (PEP) to prevent HIV transmission is important. However, PEP administration has been associated with frequent adverse effects, low compliance and difficulties to ensure a proper risk assessment. This nationwide study describes 14 years of experience with the use of PEP following blood exposure in Denmark.METHODS: A descriptive study of all PEP cases following non-sexual exposure to HIV in Denmark from 1999-2012.RESULTS: A total of 411 cases of PEP were described. There was a mean of 29.4 cases/year, increasing from 23 cases in 1999 to 49 cases in 2005 and then decreasing to 16 cases in 2012. Overall 67.2% of source patients were known to be HIV-positive at the time of PEP initiation, with no significant change over time. The median time to initiation of PEP was 2.5 h (0.15-28.5) following occupational exposure. Adverse effects were reported by 50.9% with no significant difference according to PEP regimen. In 85.1% of cases with available data, either a full course of PEP was completed or PEP was stopped because the source was tested HIV-negative. Only 6.6% stopped PEP early due to adverse effects.CONCLUSIONS: PEP in Denmark is generally prescribed according to the guidelines and the annual number of cases has declined since 2005. Adverse effects were common regardless of PEP regimens used and new drug regimens should be considered.

U2 - 10.3109/23744235.2015.1103896

DO - 10.3109/23744235.2015.1103896

M3 - Journal article

C2 - 26529586

VL - 48

SP - 195

EP - 200

JO - Infectious Diseases

JF - Infectious Diseases

SN - 2374-4235

IS - 3

ER -